Triggering mechanisms of brainstem saccade generator by saccade area of the superior colliculus.

• Project/Area Number: 19500347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SUGIUCHI Yuriko Tokyo Medical and Dental University, 医歯学総合研究科, 准教授 (30251523)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 運動系神経生理学 / 上丘 / inhibitory burst neuron / pause neuron / saccade / 固視

Research Abstract

We have analyzed neural brainstem mechanism for rapid eye movements (saccades). The superior colliculus (SC) has been known to be involved in controlling saccade, but neural mechanism of triggering saccade has been kept unrevealed for a long time. This study has shown the reciprocal relationship between mechanisms of generation of saccades and visual fixation in the SC, and that this reciprocity itself is deeply involved in triggering mechanism of saccades.

Research Products

• [Journal Article] 上丘における機能局在について (2010)
  • Author(s): 杉内友理子, 高橋真有
  • Journal Title: Equilibrium Res. 69 Pages: 58-63
  • NAID: 10026088717
  • Peer Reviewed
• [Journal Article] 上丘における機能局在について (2010)
  • Author(s): 杉内友理子, 高橋真有
  • Journal Title: Equilibrium Research 69 Pages: 58-63
  • NAID: 10026088717
  • Peer Reviewed
• [Journal Article] 前庭脊髄路 (2009)
  • Author(s): 杉内友理子
  • Journal Title: Clinical Neuroscience-Motor system-What's classic and what's new? 27 Pages: 7747-7751
  • NAID: 10009387415
• [Journal Article] 前庭脊髄路 (2009)
  • Author(s): 杉内友理子
  • Journal Title: Clinical Neuroscience 27 Pages: 747-751
  • NAID: 10009387415
• [Journal Article] (2009)
  • Author(s): 杉内友理子
  • Journal Title: 日常臨床に役立つめまいと平衡障害(金原出版) Pages: 37-43
• [Journal Article] Neural circuits for triggering saccades in the brainstem (2008)
  • Author(s): Shinoda Y., Sugiuchi Y., Izawa Y., Takahashi M.
  • Journal Title: Prog. in Brain Res. 171 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Neural circuits for triggering saccades in the brainstern. (2008)
  • Author(s): Shinoda Y., Sugiuchi Y., Izawa Y., Takahashi M.
  • Journal Title: Progress in Brain Research 171 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Commissural mirror-symmetric excitation and reciprocal inhibition between the two superior colliculi and their roles in vertical and horizontal eye movements (2007)
  • Author(s): Takahashi M., Sugiuchi Y. Shinoda Y.
  • Journal Title: J. Neurophysiol. 98 Pages: 2664-2682
  • Peer Reviewed
• [Journal Article] Controversy on "fixation zone" of the superior colliculus (2007)
  • Author(s): Sugiuchi Y., Izawa Y., Takahashi M., Na J., Shinoda Y.
  • Journal Title: Neuro-ophthalmol. 31 Pages: 147-155
  • Peer Reviewed
• [Journal Article] Neural pathways for vertical saccades : from the superior colliculus to trochlear motoneurons (2007)
  • Author(s): Izawa Y., Sugiuchi Y., Shinoda Y.
  • Journal Title: Neuro-ophthalmol. 31 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons (2007)
  • Author(s): Izawa Y., Sugiuchi Y., Shinoda Y.
  • Journal Title: J. Neurophysiol. 197 Pages: 3696-3712
  • Peer Reviewed
• [Journal Article] Neural organization of the pathways from the superior colliculus totrochlear motoneurons. (2007)
  • Author(s): Izawa, Y., Sugiuchi, Y. & Shinoda Y.
  • Journal Title: Journal of Neurophysiology 97 Pages: 3696-3712
  • Peer Reviewed
• [Journal Article] Neural pathways for vertical saccades: from the superior colliculus to trochlear motoneurons. (2007)
  • Author(s): Izawa, Y., Sugiuchi, Y. & Shinoda Y.
  • Journal Title: Neuro-Ophthalmology 31 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Controversy on "Fixation zone" of the Superior Colliculus. (2007)
  • Author(s): Sugiuchi, Y., Izawa, Y., Takahashi, M., Na, J. & Shinoda, Y
  • Journal Title: Neuro-Ophthalmology 31 Pages: 147-155
  • Peer Reviewed
• [Journal Article] Commissural mirror-symmetric excitation and reciprocal inhibition between the two superior colliculi and their roles in vertical and horizontal eye movements. (2007)
  • Author(s): Takahashi, M., Sugiuchi, Y. & Shinoda, Y.
  • Journal Title: Journal of Neurophysiology 98 Pages: 2664-2682
  • Peer Reviewed
• [Journal Article] Long descending motor tract axons and their control of neck and axial muscles (2005)
  • Author(s): Shinoda Y., Sugiuchi Y., Izawa Y., Hata Y.
  • Journal Title: Prog. Brain Res. 151 Pages: 533-569
  • Peer Reviewed
• [Journal Article] Synaptic inputs and their pathways from fixation and saccade zones of the superior colliculus to inhibitory burst neurons (2005)
  • Author(s): Takahashi M., Sugiuchi Y., Izawa Y., Shinoda Y.
  • Journal Title: Ann.N.Y.Acad.Sci. 1039 Pages: 209-219
  • Peer Reviewed
• [Journal Article] Vestibular projection to the periarcuate cortex and its relation to pursuit-related area in the monkey (2005)
  • Author(s): Sugiuchi Y., Izawa Y., Ebata S., Shinoda Y.
  • Journal Title: Ann.N.Y.Acad.Sci. 1039 Pages: 111-123
  • Peer Reviewed
• [Journal Article] Physiological characterization of synaptic inputs to inhibitory burst neurons from the rostral and caudal superior colliculus (2005)
  • Author(s): Sugiuchi Y., Izawa Y., Takahashi M., Na J., Shinoda Y.
  • Journal Title: J.Neurophysiol. 93 Pages: 697-712
  • Peer Reviewed
• [Journal Article] Commissural excitation and inhibition by the superior colliculus in tectoreticular neurons projecting to omnipause neuron and inhibitory burst neuron regions (2005)
  • Author(s): Takahashi M., Sugiuchi Y., Izawa Y., Shinoda Y.
  • Journal Title: J.Neurophysiol. 94 Pages: 1707-1726
  • Peer Reviewed
• [Presentation] Neural circuit for generation of vertical saccades-Input-output organization of neurons in the interstitial nucleus of Cajal (2010)
  • Author(s): Sugiuchi Y, Takahashi M, Izawa Y, Shinoda Y.
  • Organizer: Symposium on "Advances in Oculomotor and Vestibular Systems" in honor of Prof. Edward Keller
  • Place of Presentation: Miami, USA
• [Presentation] カハル間質核細胞の入出力機構 (2009)
  • Author(s): 杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
  • Organizer: 第68回日本めまい平衡医学会総会,一般口演
  • Place of Presentation: 徳島
  • Year and Date: 2009-11-25
• [Presentation] Properties of Input-output Organization of INC Neurons as a Counterpart of IBNs in the Horizontal Saccade System (2009)
  • Author(s): 杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
  • Organizer: Neuroscience meeting,シンポジウム講演
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Input-output organization of INC neurons in the pathway from the superior colliculus to trochlear motoneurons (2009)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: Eye Movements and Vision
  • Place of Presentation: Oxford
  • Year and Date: 2009-03-31
• [Presentation] Morphological correlates for commissural mirror-symmetric excitation and reciprocal inhibition in the superior colliculi for control of saccades. (2009)
  • Author(s): Takahashi M., Sugiuchi Y., Shinoda Y.
  • Organizer: Eye Movements and Vision
  • Place of Presentation: Oxford
  • Year and Date: 2009-03-31
• [Presentation] Properties of input-output organization of INC neurons as a counterpart of IBNs in the horizontal saccade system (2009)
  • Author(s): Sugiuchi Y., Izawa Y., Takahashi M., Shinoda, Y.
  • Organizer: Neuroscience Meeting
  • Place of Presentation: Nagoya
• [Presentation] Morphological correlates for commissural mirror-symmetric excitation and reciprocal inhibition in the superior colliculi for control of saccades (2009)
  • Author(s): Takahashi, M., Sugiuchi Y., Shinoda Y.
  • Organizer: Eye Movements and Vision, A Symposium in Honor of Fred Miles
  • Place of Presentation: Oxford, UK
• [Presentation] Input-output organization of INC neurons in the pathway from the superior colliculus to trochlear motoneurons (2009)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda. Y.
  • Organizer: Eye Movements and Vision, A Symposium in Honor of Fred Miles
  • Place of Presentation: Oxford, UK
• [Presentation] カハル間質核細胞の入出力機構 (2009)
  • Author(s): 杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
  • Organizer: 第68回日本めまい平衡医学会総会
  • Place of Presentation: 徳島
• [Presentation] Functional role of commissural excitation and inhibition between the superior colliculus for control of saccadic eye movements (2008)
  • Author(s): Takahashi M., Sugiuchi Y., Shinoda Y.
  • Organizer: Neuroscience Meeting
  • Place of Presentation: Tokyo
• [Presentation] Excitatory and Inhibitory pathways from the superior colliculus to vertical ocular motoneurons (2008)
  • Author(s): Izawa Y., Sugiuchi Y., Shinoda Y.
  • Organizer: Neuroscience Meeting
  • Place of Presentation: Tokyo
• [Presentation] Functional role of the interstitial nucleus of Cajal in vertical saccade system (2008)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: Neuroscience Meeting
  • Place of Presentation: Tokyo
• [Presentation] Functional roles of commissural mirror-symmetric excitation and reciprocal inhibition between the superior colliculus for control of vertical saccades (2008)
  • Author(s): Takahashi M., Sugiuchi Y, Shinoda Y.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] Neural networks that subserves vertical saccadic eye movements (2008)
  • Author(s): Izawa Y., Sugiuchi Y., Shinoda Y.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] The Interstitial nucleus of Cajal and its functional roles in generation of vertical saccades and the vestibulo-ocular reflex (2008)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] 上丘から上斜筋運動ニューロンへの相反入力パターンの解析 (2008)
  • Author(s): 伊澤佳子, 杉内友理子, 篠田義一
  • Organizer: 第67回日本めまい平衡学会総会
  • Place of Presentation: 秋田
• [Presentation] カハル間質核細胞の垂直性サッケード生成における役割 (2008)
  • Author(s): 杉内友理子, 伊澤佳子, 高橋真有, 篠田義一
  • Organizer: 第67回日本めまい平衡学会総会
  • Place of Presentation: 秋田
• [Presentation] The interstitial nucleus of Cajal and Its functional roles in generation of vertical saccades and the vestibulo-ocular reflex (2008)
  • Author(s): Sugiuchi, Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] Neural networks that subserves vertical saccadic eye movements. (2008)
  • Author(s): Izawa Y., Sugiuchi Y., Shinoda Y.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] Functional roles of commissural Mirror-symmetric excitation and reciprocal inhibition between the superior colliculus for control of vertical saccades. (2008)
  • Author(s): Takahashi M., Sugiuchi, ShinodaY.
  • Organizer: The 25th Barany Society Meeting
  • Place of Presentation: Kyoto
• [Presentation] Functional role of the interstitial nucleus of Cajal in vertical saccade system. (2008)
  • Author(s): Sugiuchi, Y., Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: Neuroscience 2008, Workshop
  • Place of Presentation: Tokyo
• [Presentation] Excitatory and Inhibitory pathways from the superior colliculus to vertical ocular motoneurons. (2008)
  • Author(s): Izawa Y., Sugiuchi, Y., Shinoda Y.
  • Organizer: Neuroscience 2008, Workshop
  • Place of Presentation: Tokyo
• [Presentation] Functional role of commissural excitation and inhibition between the superior colliculus for control of saccadic eye movements. (2008)
  • Author(s): Takahashi M., Sugiuchi, Y., Shinoda Y.
  • Organizer: Neuroscience 2008, Workshop
  • Place of Presentation: Tokyo
• [Presentation] 前庭系による運動制御の神経機構-前庭脊髄路と前庭皮質投射について- (2008)
  • Author(s): 杉内友理子
  • Organizer: 第23回日本大脳基底核研究会
  • Place of Presentation: 河口湖町
• [Presentation] Functional roles of the interstitial nucleus of Cajal in generation of vertical saccades. (2008)
  • Author(s): Sugiuchi, Y., Izawa, Y., Takahashi, M. & Shinoda, Y.
  • Organizer: Satellite Symposium to the 25th Barany Society Meeting
  • Place of Presentation: Ohtsu. Japan
• [Presentation] Output pathways from the superior colliculus that subserves vertical saccades. (2008)
  • Author(s): Izawa, Y., Sugiuchi, Y. & Shinoda, Y.
  • Organizer: Satellite Symposium to the 25th-Barany Society Meeting
  • Place of Presentation: Ohtsu. Japan
• [Presentation] Commissural mirror symmetric excitation and reciprocal inhibition between the two superior colliculi and their morphological correlates. (2008)
  • Author(s): Takahashi, M, Sugiuchi, Y. & Shinoda, Y.
  • Organizer: Satellite Symposium to the 25th Barany Society Meeting
  • Place of Presentation: Ohtsu. Japan
• [Presentation] Neural mechanisms for triggering saccades (2007)
  • Author(s): Shinoda, Y. Sugiuchi Y., Izawa Y., Takahashi, M.
  • Organizer: Gordon Research Conference (Oculomotor System Biology)
  • Place of Presentation: Lewiston, USA
• [Presentation] Functional roles of point-to-point commissural connections between the superior colliculi for control of suppression and generation of saccades (2007)
  • Author(s): Takahashi, M. Sugiuchi Y., Shinoda Y.
  • Organizer: Gordon Research Conference (Oculomotor System Biology)
  • Place of Presentation: Lewiston, USA
• [Presentation] Neural pathways mediating excitation and inhibition from the superior colliculus to vertical ocular motoneurons (2007)
  • Author(s): Izawa, Y. Sugiuchi Y., Shinoda Y.
  • Organizer: Gordon Research Conference (Oculomotor System Biology)
  • Place of Presentation: Lewiston, USA
• [Presentation] Differential neural connections of the rostral and caudal superior colliculi with inhibitory burst neurons and omnipause neurons in the brainstem (2007)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: Gordon Research Conference (Oculomotor System Biology)
  • Place of Presentation: Lewiston, USA
• [Presentation] Brainstem mechanisms of initiation and suppression of saccades (2007)
  • Author(s): Shinoda, Y. Sugiuchi Y., Izawa Y., Takahashi, M.
  • Organizer: A satellite symposium to the 17th Meeting of the Neural Control of Movement Society "Neural basis of motor learning and performance : from cell to function"
  • Place of Presentation: Carmona, Spain
• [Presentation] Functional roles of commissural connections between the superior colliculi for control of saccades (2007)
  • Author(s): Takahashi, M. Sugiuchi Y., Shinoda Y.
  • Organizer: A satellite symposium to the 17th Meeting of the Neural Control of Movement Society "Neural basis of motor learning and performance : from cell to function"
  • Place of Presentation: Carmona, Spain
• [Presentation] Neural organization of the pathways from the superior colliculus to vertical oclular motoneurons (2007)
  • Author(s): Izawa, Y. Sugiuchi Y., Shinoda Y.
  • Organizer: A satellite symposium to the 17th Meeting of the Neural Control of Movement Society "Neural basis of motor learning and performance : from cell to function"
  • Place of Presentation: Carmona, Spain
• [Presentation] Neural connections of the superior colliculus with the brainstem saccade generator (2007)
  • Author(s): Sugiuchi Y. Izawa Y., Takahashi M., Shinoda Y.
  • Organizer: A satellite symposium to the 17th Meeting of the Neural Control of Movement Society "Neural basis of motor learning and performance : from cell to function"
  • Place of Presentation: Carmona, Spain
• [Presentation] 前頭眼野近傍の滑動性眼球運動領域への入力経路 (2007)
  • Author(s): 杉内友理子, 伊澤佳子, 篠田義一
  • Organizer: 第66回日本めまい平衡医学会総会
  • Place of Presentation: 大阪
• [Presentation] 垂直性・水平性サッケードにおける両側上丘間の交連性興奮・抑制の役割 (2007)
  • Author(s): 高橋真有, 杉内友理子, 篠田義一
  • Organizer: 第66回日本めまい平衡医学会総会
  • Place of Presentation: 大阪
• [Presentation] 水平性サッケードと垂直性サッケードの出力神経機構 (2007)
  • Author(s): 伊澤佳子, 杉内友理子, 篠田義一
  • Organizer: 第66回日本めまい平衡医学会総会
  • Place of Presentation: 大阪
• [Presentation] Neural pathways mediating excitation and inhibition from the superior colliculus to vertical ocular motoneurons. (2007)
  • Author(s): Izawa, Y., Sugiuchi, Y. & Shinoda Y.
  • Organizer: Gordon Research Conference
  • Place of Presentation: Lewiston, USA
• [Presentation] Neural mechanisms for triggering saccades. (2007)
  • Author(s): Shinoda Y2 Izawa, Y, & Takahashi. M
  • Organizer: Gordon Research Conference
  • Place of Presentation: Lewiston, USA
• [Presentation] Functional roles of point-to point commissural connections between the superior colliculi for control of suppression and generation of saccades. (2007)
  • Author(s): Takahashi, M., Sugiuchi, Y. & Shinoda Y.
  • Organizer: Gordon Research Conference
  • Place of Presentation: Lewiston, USA
• [Presentation] Differential neural connections of the rostral and caudal superior colliculi with inhibitory burst neurons and omnipause neurons in the brainstem. (2007)
  • Author(s): Sugiuchi Y., Izawa, Y., Takahashi, M. & Shinoda, Y.
  • Organizer: Cordon Research Conference
  • Place of Presentation: Lewiston, USA
• [Presentation] 前頭眼野近傍の滑動性眼球運動領野への入力経路 (2007)
  • Author(s): 杉内友理子, 伊澤佳子, 篠田義一
  • Organizer: 第66回日本めまい平衡医学会総会
  • Place of Presentation: 大阪
• [Book] 日常臨床に役立つ めまいと平衡障害(内野善生・古屋信彦編集) (2009)
  • Author(s): 杉内友理子
  • Publisher: 金原出版