Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T
| Project/Area Number |
19500357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KURIHARA Satoshi Jikei University School of Medicine, 医学部, 教授 (90057026)
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| Co-Investigator(Kenkyū-buntansha) |
HONGO Kenichi 東京慈恵会医科大学, 医学部, 准教授 (00256447)
KOMUKAI Kimiaki 東京慈恵会医科大学, 医学部, 講師 (60360145)
SASAKI Hiroyuki 東京慈恵会医科大学, 医学部, 准教授 (60170693)
FUKUDA Norio 東京慈恵会医科大学, 医学部, 講師 (30301534)
MORIMOTO Sachio 九州大学, 医学研究科, 准教授 (50202362)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋 / トロポニンT / Ca^<2+>感受性 / アンギオテンシンII受容体 / Ca^<2+> / トロポニン / 細胞内Ca^<2+> / 筋小胞体 / Ca感受性 / 拡張型心筋症 / Caトランジェント / アンギオテンシンII / DCM / マウス / 細胞内Ca / Ca transient / レニン・アンギオテンシン系 / 心エコー / Ca 感受性 / 細胞内Ca2^<2+> / CaMKII |
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| Research Abstract |
We explored the mechanism of pathogenesis and sudden death in dilated cardiomyopathy using knock-in mouse model with mutant troponin T (DCM mouse). DCM mouse died suddenly from age of 1 month old. In DCM mouse, cardiac chamber was dilated and contractile functions were impaired. A blocker of angiotensin II receptor (ARB) significantly increased survival rate and improved the cardiac functions without changing the decreased Ca^<2+> sensitivity in DCM mouse. ARB also improved the fibrosis and electrocardiogram, which were considered as critical for the beneficial effects of ARB.
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Report
(4 results)
Research Products
(46 results)
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[Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse2009
Author(s)
Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
Organizer
The XXXVI International Congress of Physiological Sciences
Place of Presentation
京都
Related Report
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[Presentation] Rennin-angiotensin system plays an important role in the pathogenesis of DCM in mouse.2009
Author(s)
Hongo K, Morimoto S, O-uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
Organizer
The XXXVI International Congress of Physiological Sciences
Place of Presentation
京都
Related Report
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[Presentation] Protein kinase A-based modulation of Ca^<2+> sensitivity in skinnedskeletal muscle fibers reconstituted with cardiac troponin.2009
Author(s)
Fukuda N, Matsuba D, Terui T, 0-Uchi J, Tanaka H^<1)>, Ojima T <1)>, Ohtsuki I, Ishiwata S^<2)>, Kurihara S(<1>)Hokkaido University, ^<2)>Waseda University)
Organizer
Biophysical Society 53rd Annual Meeting
Place of Presentation
Boston, USA
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[Presentation] Microscopic analysis of sarcomeric oscillatioins by quantum dots in skinned rat ventricular myocytres.2008
Author(s)
Serizawa T^<1)>, 0-Uchi J, Fukuda N, Kurihara S, Ishiwata S^<l)2)>(^<l)>Graduate school of pure, applied physics, Waseda University, <1)2)>^Department of physics, school of science, engineering, Waseda University)
Organizer
第46回日本生物物理学会年会.
Place of Presentation
福岡
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