Bone abnormalities and unilateral eye deterioration in aspartate-glutamate carrier deficient mice
Project/Area Number |
19500365
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Kagoshima University |
Principal Investigator |
IIJIMA Mikio Kagoshima University, 大学院・医歯学総合研究科, 助教 (00305111)
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Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Shirou 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70073666)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | アスパラギン酸グルタミン酸輸送体 / アスパラギン酸・グルタミン酸輸送体 / 脳・神経 / 骨 |
Research Abstract |
Aspartate-glutamate carrier deficient mice (citrin^<-/->, aralar^<+/-> mice) demonstrated growth retarded rate and bone abnomalities compared with their citrin-KO (citrin^<-/->, aralar^<+/+> mice) littermates. Citrin^<-/->, aralar^<+/-> mice fail to display hyperammonemia after oral administration of sucrose which is one of features of human type II citrullinemia model mice, citrin^<-/->, mGPDH^<-/-> mice. No citrin^<-/->, aralar^<+/-> mice which is suffer from unilateral eye deterioration demonstrated both eye aberrations up to 1 year.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency.2007
Author(s)
Saheki T, Iijima M, Li MX, Kobayashi K, Horiuchi M, Ushikai M, Okumura F, Meng XJ, Inoue I, Tajima A, Moriyama M, Eto K, Kadowaki T, Sinasac DS, Tsui LC, Tsuji M, Okano A, Kobayashi T
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Journal Title
J. Biol. Chem. 282
Pages: 25041-25052
Related Report
Peer Reviewed
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