Functional analysis of mast cells in immune responses against virus and cancer

• Project/Area Number: 19500367
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Juntendo University
• Principal Investigator: USHIO Hiroko Juntendo University, 医学研究科, 准教授 (30317391)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: マスト細胞 / ウイルス感染 / Toll様受容体 / NK細胞 / レギュラトリーT細胞 / サイトカイン

Research Abstract

マスト細胞が即時型アレルギー応答だけではなく、自然免疫応答や獲得免疫応答に広く関与していること(Galli SJ et al. Nat Immunol, 6 : 135, 2005)に着目し、ウイルス感染や癌免疫応答におけるマスト細胞の役割を、マスト細胞欠損マウス(WBB6F1-W/Wv, Wsh/Wsh)にウイルス感染やNK細胞を活性化させる薬剤を投与して正常マウスと比較することにより行った。

Research Products

• [Journal Article] The human antimicrobial peptide dermcidin activates normal human keratinocytes (2009)
  • Author(s): Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K.
  • Journal Title: Br J Dermatol 160 Pages: 243-249
  • Peer Reviewed
• [Journal Article] Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA (2009)
  • Author(s): Kinoshita H, Takai T, Le AT, Kamijyo S, Wang XL, Ushio H, Hara M, Kawasaki J, Ogawa T, Gunawa H, Ikeda S, Okumura K, Ogawa H.
  • Journal Title: J All Cli Immunol 123 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Lipid- soluble components of Honeybee-Collected Pollen exert anti-allergic effect by inhibiting IgE-mediated mast cell activation in vivo (2009)
  • Author(s): Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K.
  • Journal Title: Phytotherapy Research in press
  • Peer Reviewed
• [Journal Article] Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts (2009)
  • Author(s): Ebihara N, Nakayama M, Tokura T, Ushio H, Murakami A.
  • Journal Title: Exp Eye Res in press
  • Peer Reviewed
• [Journal Article] The human antimicrobial peptide dermcidin activates normal human keratinocytes. (2009)
  • Author(s): Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K.
  • Journal Title: Br J Dermatol 160 Pages: 243-249
  • Peer Reviewed
• [Journal Article] Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA (2009)
  • Author(s): Kinoshita H, Takai T, Le AT, Kami jyo S, Wang XL, Ushio H, Hara M, Kawasaki J, Ogawa T, Gunawa H, Ikeda S, Okumura K, Ogawa H.
  • Journal Title: J All Cli Immunol 123 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis (2008)
  • Author(s): Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H.
  • Journal Title: Biochem Biophys Res Commun 365 Pages: 137-42
  • Peer Reviewed
• [Journal Article] Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation (2008)
  • Author(s): Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa
  • Journal Title: Immunology 124 Pages: 357-367
  • Peer Reviewed
• [Journal Article] Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation in vivo and in vitro (2008)
  • Author(s): Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H.
  • Journal Title: J Med Food 11 Pages: 14-20
  • Peer Reviewed
• [Journal Article] Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. (2008)
  • Author(s): Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura
  • Journal Title: Biochem Biophys Res Commun 365 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. (2008)
  • Author(s): Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H.
  • Journal Title: Immunology 124 Pages: 357-367
  • Peer Reviewed
• [Journal Article] Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis (2008)
  • Author(s): Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H
  • Journal Title: Biochem Biophys Res Commun 365 Pages: 137-42
  • Peer Reviewed
• [Journal Article] Distinct functions between Toll-like receptors 3 and 9 in retinal pigment epithelia cells (2007)
  • Author(s): Ebihara N, Chen L, Tokura T, Ushio H, Iwatsu M, Murakami A.
  • Journal Title: Ophthalmic Res 39 Pages: 155-163
  • Peer Reviewed
• [Journal Article] Expression and function of toll-like receptor-3 and-9 in human corneal myofibroblasts (2007)
  • Author(s): Ebihara N, Yamagami S, Chen L, Tokura T, Iwatsu M, Ushio H, Murakami A.
  • Journal Title: Invest Ophthalmo Vis Sci 49 Pages: 3069-3076
  • Peer Reviewed
• [Journal Article] The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor4 (2007)
  • Author(s): Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawarudana STM, Ikeda S, Okumura K, Ogawa H
  • Journal Title: J Leuk Biol 82 Pages: 657-665
  • Peer Reviewed
• [Presentation] 角膜実質細胞におけるTWEAK/Fn14システム (2008)
  • Author(s): 海老原伸行、中山勝文、戸倉智子、牛尾博子、山上聡、村上晶
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 東京
• [Presentation] Synergistic activation of murine mast cells by monomeric IgE and Toll-like receptor ligands (2008)
  • Author(s): Takenaka H, Ushio H, Niyonsaba F, Suto H, Okumura K, Ikeda S.
  • Organizer: 第5回国際研究皮膚科学会
  • Place of Presentation: 京都
• [Presentation] TSLP production by keratinocytes stimulated with double-strand RNA and Th2/TNF cytokine (2008)
  • Author(s): Kinoshita H, Takai T, Tuan LA, Kamijyo S, Ushio H, Hara M, Kawasaki J, Ogawa T, Wang XL,Gunawan H, Suto H, Ikeda S, Okumura K, Ogawa H.
  • Organizer: 第5回国際研究皮膚科学会
  • Place of Presentation: 京都
• [Presentation] 単量体IgEとToll-like receptorリガンドによる相乗的なマスト細胞活性化の検討 (2008)
  • Author(s): 竹中洋史、牛尾博子、ニヨンサバ フランソワ、須藤一、池田志斈、奥村康
  • Organizer: 第58回日本アレルギー学会
  • Place of Presentation: 東京
• [Presentation] Human β-defensins and cathelicidin LL-37 on IL-31 production in human mast cells (2008)
  • Author(s): ニヨンサバ フランソワ、牛尾博子、小川秀興、奥村康
  • Organizer: 第58回日本アレルギー学会
  • Place of Presentation: 東京
• [Presentation] Human β-defensins and cathelicidin LL-37 on IL-31 production in human mast cells (2008)
  • Author(s): ニヨンサバ フランソワ、牛尾博子、小川秀興、奥村康
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
• [Presentation] TSLP production by keratinocytes stimulated with double-strand RNA and Th2/TNF cytokines (2008)
  • Author(s): Kinoshita H, Takai T, Tuan LA, Kamijyo S, Ushio H, Hara M, Kawasaki J, Ogawa T, Wang XL, Gunawan H, Suto H, Ikeda S, Okumura K, Ogawa H.
  • Organizer: 第5回国際研究皮膚科学会
  • Place of Presentation: 京都
• [Presentation] Human β-defensins and cathelicidin LL-37 on IL-31 production in hummast cells (2008)
  • Author(s): ニヨンサバフランソワ, 牛尾博子, 小川秀興, 奥村康
  • Organizer: 第58回日本アレルギー学会
  • Place of Presentation: 東京
• [Presentation] Human β-defensins and cathelicidin LL-37 on IL-31 production in hummast cells (2008)
  • Author(s): ニョンサバフランソワ, 牛尾博子, 小川秀興, 奥村康
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
• [Presentation] マウス肝炎ウイルス感染におけるマスト細胞の役割 (2007)
  • Author(s): 田原口元子、牛尾博子、滝本一広、山田靖子
  • Organizer: 第143回日本獣医学会
  • Place of Presentation: つくば国際会議場
• [Book] マスト細胞による殺菌作用、臨床免疫・アレルギー科 (2008)
  • Author(s): 牛尾博子
  • Publisher: 科学評論社
• [Book] 臨床免疫アレルギー科/マスト細胞の殺菌作用 (2008)
  • Author(s): 牛尾博子
  • Publisher: 科学評論社
• [Book] 臨床免疫・アレルギー科 (2008)
  • Author(s): 牛尾 博子
  • Publisher: マスト細胞による殺菌作用