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Temporal and spatial analysis on muscle oxiganation dynamics using near-infrared spectroscopy

Research Project

Project/Area Number 19500376
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

KATSUYUKI Yamamoto  Hokkaido University, 大学院・情報科学研究科, 教授 (10088867)

Co-Investigator(Kenkyū-buntansha) KUDO Nobuki  北海道大学, 大学院・情報科学研究科, 助教 (30271638)
Research Collaborator KAWAHATSU Kiyonori  北海道大学, 高等教育機能開発総合センター, 教授 (80026822)
KEK Khaijun  北海道大学, 大学院・情報科学研究科, 博士課程学生
MITSUEDA Shun  
KIBE Ryuta  北海道大学, 大学院・情報科学研究科, 修士課程学生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsNIRS / 近赤外分光法 / 組織酸素濃度イメージング / 筋組織 / スポーツ医学 / リハビリテーション医学 / 組織代謝 / シミュレーション / 近赤外分光 / イメージング / 筋 / 運動負荷 / 組織酸素濃度 / 時空間解析
Research Abstract

本研究では,近赤外分光法(NIRS)を用いた絶対値計測可能な筋組織酸素濃度のイメージング装置を開発し,運動時における同一筋内や異なる筋について筋組織酸素濃度分布の計測を行い,運動強度や運動様式の違いによる酸素濃度分布の変化を把握できることを明らかにした.また,一般成人と運動選手を対象に足踏み込み運動時に協調して動作する3種類の筋の酸素濃度を計測し,装置が運動時における複数の筋の同時比較や練習効果の定量的評価に有用であることも明らかにした.さらに,実測とシミュレーションによる解析との比較により,NIRS計測波形を解釈する上で筋代謝モデルを用いた解析の有用性を明らかにした.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Sonoporation by single-shot pulsed ultrasound with microbubbles adjacent to cells2009

    • Author(s)
      Kudo, N., Okada, K., and Yamamoto, K.
    • Journal Title

      Biophysical Journal (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] mathematical model for analyses of muscle oxygenation measurements using NIR spectroscopy2009

    • Author(s)
      Kek, K. J., Kudo, N., and Yamamoto, K.
    • Journal Title

      Advances in Experimental Medicine and Biology (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Threshold curves obtained under various gaseous conditions for free radical generation by burst ultrasound-Effects of dissolved gas, microbubbles and gas transport from the air2009

    • Author(s)
      Okada, K., Kudo, N., Hassan, M. A., Kondo, T., and Yamamoto, K.
    • Journal Title

      Ultrasonics Sonochemistry 16(4)

      Pages: 512-518

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging instrument for muscle oxygenation based on spatially resolved spectroscopy2009

    • Author(s)
      Kek, K. J.
    • Journal Title

      Optics Express 16

      Pages: 18173-18187

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mathematical model for analyses of muscle oxygenation measurements using MR spectroscopy2009

    • Author(s)
      Kek, K. J.
    • Journal Title

      Oxygen Transport to Tissue 31(in print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical imaging instrument for muscle oxygenation based on spatially resolved spectroscopy2008

    • Author(s)
      Kek, K. J., Kibe, R., Niwayama, M., Kudo, N. and Yamamoto, K.
    • Journal Title

      Optics Express 16

      Pages: 18173-18187

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans2007

    • Author(s)
      Hamaoka, T., McCully, K. K., Quaresima, V., Yamamoto, K., Chance, B.
    • Journal Title

      Journal of biomedical optics 12(6)

      Pages: 62105-62105

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional imaging of muscle oxygenation and oxygen consumption in the knee extensor muscles during isometric contractions by spatially resolved near-infrared spectroscopy2007

    • Author(s)
      Kek, K. J., Miyakawa, T., Kudo, N. and Yamamoto, K.
    • Journal Title

      Proceedings of SPIE 6434

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 筋組織の光後方散乱特性を模擬したプラスチックファントムの開発と近赤外分光法への応用2007

    • Author(s)
      木部龍太, 郭凱俊, 工藤信樹, 山杢克之
    • Journal Title

      電子情報通信学会技術研究報告 107(126)

      Pages: 13-16

    • NAID

      10019580991

    • Related Report
      2008 Final Research Report
  • [Journal Article] Functional imaging of muscle oxygenation and oxygen consumption in the knee extensor muscles during isometric contractions by spatially resolved near-infrared spectroscopy2007

    • Author(s)
      K. J. Kek
    • Journal Title

      Proceedings of SPIE 6434

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans2007

    • Author(s)
      T. Hamaoka
    • Journal Title

      Journal of Biomedical Optics 12(6)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 筋組織の光後方散乱特性を模擬したプラスチックファントムの開発と近赤外分光法への応用2007

    • Author(s)
      木部龍太
    • Journal Title

      電子情報通信学会技術研究報告 107(126)

      Pages: 13-16

    • NAID

      10019580991

    • Related Report
      2007 Annual Research Report
  • [Presentation] 空間分解近赤外分光法を用いた一般成人と運動選手における大腿四頭筋の酸素濃度の計測2008

    • Author(s)
      郭凱俊, 木部龍太, 工藤信樹, 山杢克之
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 筋組織の光学特性を模擬したプラスチックファントムによる空間分解近赤外分光法の評価2008

    • Author(s)
      木部龍太, 郭凱俊, 三枝俊, 工藤信樹, 山本克之
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Measurements of quadriceps muscle oxygenation of untrained and endurance-trained subjects using spatially resolved NIRS2008

    • Author(s)
      Kek, K. J.
    • Organizer
      第47回日本生体医工学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] CCDカメラを用いた筋組織反射光強度計測による空間分解近赤外分光法の検討2007

    • Author(s)
      三枝俊, 郭凱俊, 工藤信樹, 山杢克之
    • Organizer
      第46回日本生体医工学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-04-25
    • Related Report
      2008 Final Research Report
  • [Presentation] CCDカメラを用いた筋組織反射光強度計測による空間分解近赤外分光法の検討2007

    • Author(s)
      三枝 俊
    • Organizer
      第46回日本生体医工学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2007-04-25
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://bmisys.bme.eng.hokudai.ac.jp/bim/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://bmisys.bme.ist.hokudai.ac.jp/bim/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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