Construction of 3-dimensional optical coherence tomographic for dynamic analysis of human sweat gland s

• Project/Area Number: 19500387
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University
• Principal Investigator: OHMI Masato Osaka University, 大学院・医学系研究科, 助教 (60273645)
• Co-Investigator(Kenkyū-buntansha): HARUNA Masamitsu 大阪大学, 大学院・医学系研究科, 教授 (20029333)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 生体情報 / 計測 / 光コヒーレンストモグラフ / 光周波数掃引OCT / エンフェイスOCT / OCT立体イメージ / 汗腺ダイナミクス

Research Abstract

ヒト掌の汗腺は直径約40μmのらん状の管であり、汗が真皮内の腺細胞から吸い上げられ、汗腺を通って体表に放出される。本研究では、従来のタイムドメイン方式OCT(TD-OCT)より100倍高速の光周波数掃引方式OCT (SS-OCT)を用いて、100フレーム/秒で500枚のOCTを取得し、OCT立体イメージを構築した。これを用いて汗腺のダイナミクスを立体的に追跡した。さらに、最大値投影OCT(MIP-OCT)を用いて、1mm四方に3-5本ある複数の汗腺ダイナミクスを追跡した。

Research Products

• [Journal Article] Dynamic analysis of internal and external mental sweating by optical coherence tomography (2009)
  • Author(s): M. Ohmi, M. Tanigawa, A. Yamada, Y. Ueda, M. Haruna
  • Journal Title: J. Biomed. Opt. vol.14
  • Peer Reviewed
• [Journal Article] Dynamic analysis of laser ablation of biological tissue using a real-time OCT (2009)
  • Author(s): M. Ohnishi, D. Takada, M. Ohmi, and M. Haruna
  • Journal Title: Biomedical Optics Symposium (BiOS2009), Proc. SPIE vol.7175
• [Journal Article] Maximum- intensity-projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa, Y. Ueda, M. Ohmi, M. Ohnishi, M. Kuwabara, and M. Haruna
  • Journal Title: Biomedical Optics Symposium (BiOS2009), Proc. SPIE vol.7168
  • NAID: 10025082573
• [Journal Article] Dynamic analysis of internal and external mental sweating byoptical coherence tomography (2009)
  • Author(s): M. Ohmi
  • Journal Title: Journal of Biomedical Optics Vol. 14
  • Peer Reviewed
• [Journal Article] Maximum-intensity-projection imaging for dynamic analysis ofmental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa
  • Journal Title: Proc. SPIE, Biomedical Optics Symposium Vol. 7168
• [Journal Article] Dynamic analysis of laser ablation of biological tissue using areal-time OCT (2009)
  • Author(s): M. Ohnishi
  • Journal Title: Proc. SPIE, Biomedical Optics Symposium Vol. 7175
• [Journal Article] Maximum-intensity- projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, Y. Ueda, A. Yamada, M. Ohmi, M. Ohnishi, M. Kuwabara, and M. Haruna
  • Journal Title: Appl. Phys. Express (APEX) vol.1, 098001
  • NAID: 10025082573
  • Peer Reviewed
• [Journal Article] Dynamic optical coherence tomography of small arteries and veins of human fingers (2008)
  • Author(s): M. Kuwabara, T. Fuji, M. Ohmi, and M. Haruna
  • Journal Title: Appl. Phys. Express (APEX) vol.1, 058001
  • NAID: 10025080578
  • Peer Reviewed
• [Journal Article] Maximum-intensity- projection images for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, Y. Ueda, A. Yamada, M. Ohmi, and M. Haruna
  • Journal Title: 19-th Int' l Conf. Optical Fiber Sensors (OFS-19), Proc. SPIE vol.7004
  • NAID: 10025082573
  • Peer Reviewed
• [Journal Article] Dynamic analysis of eccrin sweat glands on human fingertips by optical coherence tomography (2008)
  • Author(s): M. Haruna, M. Ohmi, Y. Ueda, A. Yamada and H. Saigusa
  • Journal Title: Biomedical Optics Symposium (BiOS2008), Proc. SPIE vol.6847
• [Journal Article] Maximum-intensity-projection imaging for dynamic analysis ofmental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa
  • Journal Title: Proc. SPIE, Int'l Conf. Optical Fiber Sensors Vol. 7004
  • Peer Reviewed
• [Journal Article] Dynamic optical coherence tomography of small arteries and veinsof human fingers (2008)
  • Author(s): M. Kuwabara
  • Journal Title: Appl. Phys. Express Vol. 1
  • Peer Reviewed
• [Journal Article] Maximum-intensity-projection imaging for dynamic analysis ofmental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa
  • Journal Title: Appl. Phys. Express Vol. 1
  • Peer Reviewed
• [Journal Article] Dynamic Analysis of Eccrin Sweat Glands on Human Fingertips by Optical Coherence Tomography (2008)
  • Author(s): M. Haruna
  • Journal Title: Proc. SPIE Biomedical Optics Symposium Vol.6847
• [Journal Article] Dynamic OCT for physiological functions of micro organs in human fingers (2007)
  • Author(s): M. Haruna, M. Ohmi, Y. Ueda, T. Fuji, A. Yamada, H. Saigusa, and M. Kuwabara
  • Journal Title: Photonics Asia, Conf. in Health Care and Biomedical Optics, Proc. SPIE vol.6826
• [Journal Article] 光コヒーレンストモグラフィを用いたヒト指汗腺の動態観察 (2007)
  • Author(s): 上田悦弘、近江雅人、春名正光
  • Journal Title: 発汗学 vol.14, no.1 Pages: 2-6
  • Peer Reviewed
• [Journal Article] 光コヒーレンストモグラフィを用いたヒト指汗腺の動態観察 (2007)
  • Author(s): 上田悦弘
  • Journal Title: 発汗学 Vol.14No.1 Pages: 2-6
  • Peer Reviewed
• [Journal Article] Dynamic OCT for physiological functions of micro organs in human fingers (2007)
  • Author(s): M. Haruna
  • Journal Title: Proc. SPIE Biomedical Optics Symposium Vol.6826
• [Presentation] OCTによる生体レーザアブレーションの動的解析 (2009)
  • Author(s): 近江雅人
  • Organizer: 電気学会 光・量子デバイス研究会
  • Place of Presentation: 理化学研究所
  • Year and Date: 2009-02-14
• [Presentation] Dynamic analysis of laser ablation of biological tissue using areal-time OCT (2009)
  • Author(s): M. Ohnishi
  • Organizer: SPIE Biomedical optics Symposium (BiOS2009)
  • Place of Presentation: San Jose, USA
  • Year and Date: 2009-01-26
• [Presentation] Maximum-intensity-projection imaging for dynamic analysis ofmental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa
  • Organizer: SPIE Biomedical Optics Symposium (BiOS2009)
  • Place of Presentation: San Jose, USA
  • Year and Date: 2009-01-25
• [Presentation] OCTによる精神性内部発汗のダイナミック解析 (2009)
  • Author(s): 谷川基務
  • Organizer: レーザー学会第29回年次大会
  • Place of Presentation: 徳島大学
  • Year and Date: 2009-01-11
• [Presentation] OCTによる精神性内部発汗のダイナミック解析 (2009)
  • Author(s): 谷川基務
  • Organizer: レーザー学会学術講演会第29回年次大会
  • Place of Presentation: 徳島大学
  • Year and Date: 2009-01-11
• [Presentation] Maximum-intensity- projection imaging for dynamic analysis of mental sweating by optical coherence tomography (2009)
  • Author(s): H. Saigusa, et.al.
  • Organizer: SPIE Biomedical Optics Symposium (BiOS2009), San Jose, CA
  • Place of Presentation: USA, Jan
• [Presentation] Dynamic optical coherence tomography of eccrin sweat glands andperipheral vessels (2008)
  • Author(s): M. Haruna
  • Organizer: Int'l Conf. Laser Appl. Life Sciences (LALS 2008)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-12-04
• [Presentation] OCTによる新たな精神性内部発汗とダイナミック解析 (2008)
  • Author(s): 谷川基務
  • Organizer: 日本光学会年次学術講演会OPJ2008
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-11-05
• [Presentation] 実時間OCTイメージングを用いた外部刺激に対する小動脈の反応追跡 (2008)
  • Author(s): 桑原光巨
  • Organizer: 日本光学会年次学術講演会OPJ2008
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-11-05
• [Presentation] 実時間OCTイメージングを用いた外部刺激に対する小静脈の反応追跡 (2008)
  • Author(s): 桑原光巨
  • Organizer: 日本光学会年次学術講演会OPJ2008
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-11-05
• [Presentation] 光コヒーレンスとモグラフィによる精神性発汗ダイナミクスの解析 (2008)
  • Author(s): 谷川基務
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] ヒト指小動脈・小静脈の実時間OCTイメージングと機能解析 (2008)
  • Author(s): 桑原光巨
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] 高速OCTによる生体レーザアブレーションの動的解析 (2008)
  • Author(s): 大西 誠
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] 光コヒーレンストモグラフィによる精神性発汗ダイナミクスの解析 (2008)
  • Author(s): 谷川基務
  • Organizer: 生体医工学シンポジウム2008
  • Place of Presentation: 大阪大学
  • Year and Date: 2008-09-19
• [Presentation] 光コヒーレンストモグラフィを用いた発汗測定方法 (2008)
  • Author(s): 春名正光
  • Organizer: 第16回日本発汗学会総会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2008-09-06
• [Presentation] OCTによるヒト指小動脈・小静脈の実時間イメージング (2008)
  • Author(s): 桑原光巨
  • Organizer: 第47回生体医工学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-05-08
• [Presentation] OCTによる生体レーザアブレーションのダイナミック解析 (2008)
  • Author(s): 大西 誠
  • Organizer: 第47回生体医工学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-05-08
• [Presentation] OCTによるヒト下指小動脈・小静脈の実時間動態イメージング (2008)
  • Author(s): 桑原光巨
  • Organizer: 第47回生体医工学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-05-08
• [Presentation] Maximum-intensity-projection images for dynamic analysis ofmental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa
  • Organizer: 19-th Int'l Conf. Optical Fiber Sensors (OFS-19)
  • Place of Presentation: Perth, Australia
  • Year and Date: 2008-04-15
• [Presentation] 高速OCTによるヒト指小動脈のインビボ動態観察 (2008)
  • Author(s): 桑原光巨
  • Organizer: レーザー学会第28回年次大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-01-31
• [Presentation] Dynamic analysis of eccrin sweat glands on human fingertips by optical coherence tomography (2008)
  • Author(s): M. Haruna
  • Organizer: SPIE Biomedical Optics Symposium (BiOS2008)
  • Place of Presentation: San Jose,USA
  • Year and Date: 2008-01-23
• [Presentation] Dynamic optical coherence tomography of eccrin sweat glands and peripheral vessels (2008)
  • Author(s): M. Haruna, et.al.
  • Organizer: Int'l Conf. Laser Appl. in Life Sciences (LALS 2008), Taipei Int'l Convention Center
  • Place of Presentation: Taiwan
• [Presentation] Maximum-intensity- projection images for dynamic analysis of mental sweating by optical coherence tomography (2008)
  • Author(s): H. Saigusa, et.al.
  • Organizer: 19-th Int'l Conf. Optical Fiber Sensors (OFS-19)
  • Place of Presentation: Perth, Australia
• [Presentation] Dynamic imaging of small arteries and veins of human fingers by optical coherence tomography (2008)
  • Author(s): M. Kuwabara, et.al.
  • Organizer: OSA Biomedical Optics Topical Meeting (BIOMED)
  • Place of Presentation: St. Petersburg, USA
• [Presentation] Dynamic analysis of eccrin sweat glands on human fingertips by optical coherence tomography (2008)
  • Author(s): M. Haruna, et.al.
  • Organizer: SPIE Biomedical Optics Symposium (BiOS2008)
  • Place of Presentation: San Jose, CA, USA
• [Presentation] MIP-OCTによる精神性発汗の定量解析 (2007)
  • Author(s): 三枝裕之
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによる精神性発汗ダイナミクス解析を利用した交感神経の活動評価 (2007)
  • Author(s): 山田晃寛
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] 安静時におけるヒト指小動脈・小静脈のOCT動態観察 (2007)
  • Author(s): 桑原光巨
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによるヒト表皮下生理機能の動態解析 (2007)
  • Author(s): 春名正光
  • Organizer: 日本光学会年次学術講演会OPJ2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによるヒト表皮下生理機能の動態解析 (2007)
  • Author(s): 春名正光
  • Organizer: Optics & Photonics Japan 2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] OCTによる精神性発汗ダイナミクス解析を利用した交感神経の活動評価 (2007)
  • Author(s): 山田晃宏
  • Organizer: Optics & Photonics Japan 2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] MIP-OCTによる精神性発汗の定量解析 (2007)
  • Author(s): 三枝裕之
  • Organizer: Optics & Photonics Japan 2007
  • Place of Presentation: 大阪大学
  • Year and Date: 2007-11-26
• [Presentation] Dynamic OCT for physiological function of micro organs in human fingers (2007)
  • Author(s): M. Haruna
  • Organizer: Conference in Health Care and Biomedical Optics (Photonics Asia)
  • Place of Presentation: Beijing, China
  • Year and Date: 2007-11-12
• [Presentation] Microscopic analysis of sweating dynamics of a human fingertip by optical coherence tomography (2007)
  • Author(s): A. Yamada
  • Organizer: 13th Micro Optic Conference (MOC'07)
  • Place of Presentation: Kagawa, Japan
  • Year and Date: 2007-10-30
• [Presentation] OCTによる精神性発汗の定量解析II-SS-OCTの利用とMIPイメージの構築- (2007)
  • Author(s): 三枝裕之
  • Organizer: 第68回応用物理学学術講演会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] OCTによる精神性発汗の定量解析I-発汗量の評価と能動汗腺の反応測定- (2007)
  • Author(s): 山田晃寛
  • Organizer: 第68回応用物理学学術講演会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] OCTによる精神性発汗の定量解析I -発汗量の評価と能動汗腺の反応測定- (2007)
  • Author(s): 山田晃宏
  • Organizer: 第68回応用物理学学術講演会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] OCTによる精神性発汗の定量解析I -SS-OCTの利用とMIPイメージの構築- (2007)
  • Author(s): 三枝裕之
  • Organizer: 第68回応用物理学学術講演会
  • Place of Presentation: 北海道工業大学
  • Year and Date: 2007-09-06
• [Presentation] Maximum-intensity-projection images of human sweat glands using optical coherence tomography (2007)
  • Author(s): Y. Ueda
  • Organizer: Conference on Lasers and Electro-Optics (CLEO-PR2007)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-08-28
• [Presentation] OCTを用いた精神性発汗における能動汗腺の反応測定 (2007)
  • Author(s): 山田晃寛
  • Organizer: 第15回日本発汗学会総会
  • Place of Presentation: 埼玉医科大学
  • Year and Date: 2007-08-24
• [Presentation] An approach to high-resolution OCT analyzer for laser ablation of biological tissue (2007)
  • Author(s): M. Ohmi
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics (APBP2007)
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2007-07-09
• [Presentation] Quantitative analysis of mental-stress-induced sweating on a human fingertip by dynamic OCT (2007)
  • Author(s): M. Ohmi
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics (APBP2007)
  • Place of Presentation: Cairns, Australia
  • Year and Date: 2007-07-09
• [Presentation] OCTによる発汗ダイナミクスの解明 (2007)
  • Author(s): 近江雅人
  • Organizer: 第39回光波センシング技術研究会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2007-06-12
• [Presentation] OCTによるヒト指汗腺の動態機能解析へのアプローチ (2007)
  • Author(s): 近江雅人
  • Organizer: 第46回日本生体医工学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-04-26
• [Presentation] Dynamic OCT for physiological functions of micro organs in human fingers (2007)
  • Author(s): M. Haruna, et.al.
  • Organizer: Photonics Asia, Conf. in Health Care and Biomedical Optics, Jiuha Grand Convention Center
  • Place of Presentation: Beijing, China
• [Presentation] Microscopic analysis of sweating dynamics of a human fingertip by optical coherence tomography (2007)
  • Author(s): A. Yamada, et.al.
  • Organizer: The 13-th Microoptics Conf. (MOC' 07)
  • Place of Presentation: Takamatsu, Japan
• [Presentation] Maximum-intensity- projection images of human sweat glands using optical coherence tomography (2007)
  • Author(s): Y. Ueda, et.al.
  • Organizer: The 7-th Pacific Rim Conf. on Lasers & Electro-Optics (CLEO/PR2007)
  • Place of Presentation: COEX, Seoul, Korea
• [Presentation] Dynamic OCT for physiological function of venules of human fingers (2007)
  • Author(s): T. Fuji, et.al.
  • Organizer: 7-th Pacific Rim Conf. on Lasers & Electro-Optics (CLEO/PR2007)
  • Place of Presentation: COEX, Seoul, Korea
• [Presentation] Quantitative analysis of mental-stress- induced sweating on a human fingertip by dynamic OCT (2007)
  • Author(s): M. Ohmi, et.al.
  • Organizer: 3-rd Asian and Pacific-Rim Symposium on BioPhotonics (APBP2007)
• [Presentation] An approach to high-resolution OCT analyzer for laser ablation of biological tissue (2007)
  • Author(s): M. Ohmi, .
  • Organizer: 3-rd Asian and Pacific-Rim Symposium on BioPhotonics (APBP2007)
  • Place of Presentation: Cairns, Australia