The analysis of role of ATF3 on far-infrared ray radiation

• Project/Area Number: 19500390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokushima
• Principal Investigator: YAMASHITA Kikuji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30182497)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 医用光 / 熱工学 / 遠赤外線 / 癌 / ATF3 / 遠赤外線CO_2インキュベーター / 遠赤外線動物飼育装置 / 癌細胞 / マイクアレー / siRNA / A431 / HSC3 / Sa3

Research Abstract

遠赤外線により強く増殖が卸制される細胞に共通の遺伝子であるATF3を外陰部癌A431、舌癌HSC3、歯肉癌Sa3細胞に導入した過剰発現細胞は、増殖が抑制されることが明らかになり、細胞の膨潤変化も認められた。また、siRNA法を用いて作製されたATF3遺伝子抑制舌癌HSC3細胞は、遠赤外線による増殖抑制効果が軽減された。この発見により、遠赤外線効果をもたらす薬剤の開発や臨床応用が可能になるものと考えられる。

Research Products

• [Journal Article] The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein(HSP)70A (2008)
  • Author(s): Ishibashi J, Yamashita K, Ishikawa H, et.al.
  • Journal Title: Medical Oncology 25(2) Pages: 229-237
  • Peer Reviewed
• [Journal Article] The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A (2008)
  • Author(s): Ishibashi J
  • Journal Title: Medical Oncology 25(2) Pages: 229-237
  • Peer Reviewed
• [Presentation] Possibility of far infrared ray as physical therapy for cancer (2009)
  • Author(s): Kikuii Yamashita
  • Organizer: The 1st International Mini Symposium on Wave Biotechnology
  • Place of Presentation: Doiigguk Univ. (Seoul)
  • Year and Date: 2009-03-25
• [Presentation] Possibility of far-infrared ray as physical therapy for cancer (2009)
  • Author(s): Kikuji Yamashita
  • Organizer: The 1st International Mini Symposium on Wave Biotechnology
  • Place of Presentation: Dongguk Univ. (Seoul)
  • Year and Date: 2009-03-25
• [Presentation] がんに効果が期待される物理2009.4.療法 (2008)
  • Author(s): 山下菊治
  • Organizer: 第4回日本腫瘍学会学術集会
  • Place of Presentation: 日本教育会館(東京)
  • Year and Date: 2008-07-13
• [Presentation] がんに効果が期待される物理療法 (2008)
  • Author(s): 山下菊治
  • Organizer: 第4回日本腫瘍学会 学術集会
  • Place of Presentation: 日本教育会館(東京)
  • Year and Date: 2008-07-13
• [Patent(Industrial Property Rights)] 遠赤外線を放射する癌治療器具 (2004)
  • Inventor(s): 山下菊治
  • Patent Publication Number: 2006-055540
  • Filing Date: 2004-08-23
• [Patent(Industrial Property Rights)] インキュベータおよび細胞培養装置 (2003)
  • Inventor(s): 山下菊治
  • Patent Publication Number: 2004-305137
  • Filing Date: 2003-04-09