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OMRI resonator for imaging Systema digestorium diseases in animal

Research Project

Project/Area Number 19500391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKyushu University

Principal Investigator

ICHIKAWA Kazuhiro  Kyushu University, 大学院・薬学研究院, 准教授 (10271115)

Co-Investigator(Kenkyū-buntansha) 山田 健一  九州大学, 大学院・薬学研究院, 准教授 (60346806)
安川 圭司  九州大学, 大学院・薬学研究院, 助教 (80372738)
Co-Investigator(Renkei-kenkyūsha) YAMADA Ken-ichi  九州大学, 大学院・薬学研究院, 准教授 (60346806)
YASUKAWA Keiji  九州大学, 大学院・薬学研究院, 助教 (80372738)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords医用・生体画像 / 生体レドックス / 微小共振器 / バイオテクノロジー / 生物・生体工学 / 可視化 / 生物物理
Research Abstract

本研究では、消化器疾患モデルのレドックス画像化を行うために、生体挿入可能な共振器の開発を行った。共振器方式、コーティング材料を検討した結果、高効率の超小型共振器の製作に成功した。本共振器の有効性は、疑似試料を用いて検証した。また、実験動物代表に挿入後、高感度の局所レドックス画像が得られた。以上の成果により、消化器疾患を対象とする挿入型小型共振器製作の要素技術を確立した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] Analysis of in vivo redox status with magnetic resonance technique2009

    • Author(s)
      Ichikawa K, Yamada K, Yasukawa K, Utsumi H.
    • Journal Title

      Yakugaku Zasshi.129 3

      Pages: 273-8

    • NAID

      110007123177

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of in vivo redox status with magnetic resonance technique2009

    • Author(s)
      Ichikawa K, et al.
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 273-8

    • NAID

      110007123177

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microdialysis technique2008

    • Author(s)
      Shiba T, Yamato M, Kudou W, Ichikawa K, Yamada K, Watanabe T, Utsumi H.
    • Journal Title

      J Pharm Sci.97 4101-7

      Pages: 9-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of nitroxyl spin probes in mouse brain by X-band ESR with microdialysis technique2008

    • Author(s)
      Shiba, T, et al.
    • Journal Title

      J. Pharma Sci. 97

      Pages: 4101-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad2007

    • Author(s)
      Ichikawa K, Sakabe E, Kuninobu K, Yamori T, Tsuruo T, Yao T, Tsuneyoshi M, Utsumi H.
    • Journal Title

      Antioxid Redox Signal. 9 10

      Pages: 1699-707

    • Related Report
      2008 Final Research Report
  • [Journal Article] Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI2007

    • Author(s)
      Matsumoto S, Yamada K, Hirata H, Yasukawa K, Hyodo F, Ichikawa K, Utsumi H.
    • Journal Title

      Magn Reson Med57 4

      Pages: 806-11

    • Related Report
      2008 Final Research Report
  • [Journal Article] Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad2007

    • Author(s)
      Ichikawa K, et. al.
    • Journal Title

      Antioxid Redox Signal. 9

      Pages: 1699-1707

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI2007

    • Author(s)
      Matsumoto S, et. al.
    • Journal Title

      Magn Reson Med. 57

      Pages: 806-811

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 試料搬送型OMRI 装置における画像化アルゴリズム2009

    • Author(s)
      市川和洋, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 試料搬送型OMRI装置における画像化アルゴリズム2009

    • Author(s)
      市川和洋, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Imaging in vivo redox status in tumor using OMRI /nitroxyl spin probe technique2008

    • Author(s)
      Ichikawa K et.al.
    • Organizer
      SFRBM2008
    • Place of Presentation
      Indianapolis,USA
    • Year and Date
      2008-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging in vivo redox status in tumor using OMRI/nitroxyl spin probe technique2008

    • Author(s)
      Ichikawa K, et al.
    • Organizer
      SFRBM2008
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      2008-11-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Imaging in vivo redox status in tumor using OMRI /nitroxyl spin probe technique2008

    • Author(s)
      Ichikawa K et.al.
    • Organizer
      EPR2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-09-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging in vivo redox status in tumor using OMRI/nitroxyl spin probe technique2008

    • Author(s)
      Ichikawa K, et al.
    • Organizer
      EPR2008
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-09-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 磁気共鳴法を用いた生体レドックス画像化2008

    • Author(s)
      市川和洋ほか
    • Organizer
      日本薬学会第128年会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Magnetic resonance imaging of in vivo redox status2007

    • Author(s)
      Ichikawa, K.. et.al.
    • Organizer
      ISESS-SEST 2007
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2007-11-07
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Pharmacodynamics of nitroxyl spin probes in in situ rodent liver perfusion system2007

    • Author(s)
      Ichikawa, K.. et.al.
    • Organizer
      EPR2007
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-05-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Pharmacodynamics of nitroxyl spin probes in in situ rodent liver perfusion system2007

    • Author(s)
      Ichikawa K., et. al.
    • Organizer
      EPR2007
    • Place of Presentation
      Chicago,USA
    • Year and Date
      2007-05-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Simultaneous molecular imaging technique of redox reactions monitored by Overhauser enhanced magnetic resonance imaging with nitroxyl radicals2007

    • Author(s)
      Ichikawa, K.. et.al.
    • Organizer
      PSWC2007
    • Place of Presentation
      Amsterdam, Nederland
    • Year and Date
      2007-04-25
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Remarks]

    • URL

      http://210.233.60.66/~kaiseki/

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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