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Development of Cellular and Molecular Magnetic Resonance Imaging and Application using targeted multimodal probes.

Research Project

Project/Area Number 19500401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

AOKI Ichio  National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダー (10319519)

Co-Investigator(Kenkyū-buntansha) TANAKA Chuzo  明治国際医療大学, 医学教育研究センター, 教授 (80163541)
KANNO Iwao  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, センター長 (10360356)
Co-Investigator(Renkei-kenkyūsha) TANAKA Chuzo  明治国際医療大学, 医学教育研究センター, 教授 (80163541)
KANNO Iwao  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, センター長 (10360356)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords医用 / 生体画像 / 高磁場MRI / ナノ粒子 / リポソーム / 腫瘍 / 化学療法 / 温度感受性ポリマー
Research Abstract

高磁場MRIを用いて、(1)Ca2+チャネルを通過するマンガン造影剤を使用し、脳虚血後に生じるグリア細胞の増殖であるグリオーシスのin vivo検出および経時的観察に成功した、(2)DDS技術による腫瘍集積性を生かしたフラーレン・マンガン造影剤を使用した微小腫瘍の検出、および超音波/光治療の効果判定と経時的追跡を行った、(3)光イメージングにおいて良好な周波数分解能を持つカンタムドット(Quantum dots; QD)を使用した光・MRIのハイブリッド造影剤の開発に成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (54 results)

All 2009 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (30 results) Book (5 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses: 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes2009

    • Author(s)
      Sawada K, Sun XZ, Fukunishi K, Kashima M, Sakata-Haga H, Tokado H, Aoki I, Fukui Y
    • Journal Title

      Brain Struct Funct. 2009 Feb 12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl Radicals for Labeling of Conventional Therapeutics and Noninvasive Magnetic Resonance Imaging of Their Permeability for Blood-Brain Barrier: Relationship between Structure, Blood Clearance, and MRI Signal Dynamic in the Brain2009

    • Author(s)
      Zhelev Z, Bakalova R, Aoki I, Matsumoto KI, Gadjeva V, Anzai K, Kanno I.
    • Journal Title

      Mol Pharm. 2009 Feb 10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam2009

    • Author(s)
      Matsumoto KI, Nagata K, Yamamoto H, Endo K, Anzai K, Aoki I.
    • Journal Title

      Magnetic Resonance in Medicine 61(5)

      Pages: 1033-1039

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses : 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes2009

    • Author(s)
      Sawada K, Sun XZ, Fukunishi K, Kashima M, Sakata-Haga H, Tokado H, Aoki I, Fukui Y.
    • Journal Title

      Brain Structure and Function

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl Radicals for Labeling of Conventional Therapeutics and Noninvasive Magnetic Resonance Imaging of Their Permeability for Blood-Brain Barrier : Relationship between Structure, Blood Clearance, and MRI Signal Dynamic in the Brain(DOI:10.1021/mp800175k)2009

    • Author(s)
      Zhelev Z, Bakalova R, Aoki I, Matsumoto KI, Gadjeva V, Anzai K, Kanno I.
    • Journal Title

      Molecular Pharmaceutics

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics2009

    • Author(s)
      Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I.
    • Journal Title

      Chemical Communications Issue 1

      Pages: 53-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics2008

    • Author(s)
      Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I
    • Journal Title

      Chem Commun (Camb)2009 Jan 7;(1):53-5. Epub 2008 Nov 13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects2008

    • Author(s)
      Bakalova R, Zhelev Z, Aoki I, Masamoto K, Mileva M, Obata T, Higuchi M, Gadjeva V, Kanno I
    • Journal Title

      Bioconjug Chem 2008 Jun;19(6

      Pages: 1135-1142

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multimodal silica-shelled quantum dots : direct intracellular delivery, photosensitization, toxic, and microcir culation effects2008

    • Author(s)
      Bakalova R, Zhelev Z, Aoki I, Masamoto K, Mileva M, Obata T, Higuchi M, Gadjeva V, Kanno I.
    • Journal Title

      Bioconjugate Chemistry 19(6)

      Pages: 1135-1142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of cortical laminar architecture using manganese-enhanced MRI2008

    • Author(s)
      Afonso C.Silva, Jung Hee Lee, Carolyn W-H.Wu, Jason Tucciarone, Galit Pelled, Ichio Aoki, Alan P.Koretsky
    • Journal Title

      Journal of Neuroseience Methods 167

      Pages: 246-257

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動物用MRイメージング計測2008

    • Author(s)
      青木 伊知男
    • Journal Title

      遺伝子医学MOOK 9

      Pages: 101-106

    • Related Report
      2007 Annual Research Report
  • [Journal Article] DDSによるMR分子イメージングヘ2008

    • Author(s)
      青木 伊知男、バカロバルミアナ
    • Journal Title

      Drug Delivery System 23

      Pages: 61-68

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multimodal and biocompatible quantum dots - strategy of design2007

    • Author(s)
      Bakalova, R., Zhelev, Z., Aoki, I., Kanno, I
    • Journal Title

      Nature Photonics 1(9)

      Pages: 487-489

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal response to Shepard's tones. An auditory fMRI study using multifractal analysis2007

    • Author(s)
      Shimizu Y, Umeda M, Mano H, Aoki I, Higuchi T, Tanaka C
    • Journal Title

      Brain Res Epub 2007 Oct 16

      Pages: 113-123

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal response to Shepard's tones: an auditory fMRI study using multifractal analysis2007

    • Author(s)
      Yu Shimizu, Masahiro Umeda, Ichio Aoki, Toshihiro Higuchi, Chuzo Tanaka, et. al.
    • Journal Title

      Brain Research 1186

      Pages: 113-123

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Designing quantum-dots probes2007

    • Author(s)
      Rumiana Bakalova-Zheleva, Zhivko Zhelev, Ichio Aoki, Iwao Kanno
    • Journal Title

      Nature Photonics 1

      Pages: 487-489

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Koretsky AP. Detection of cortical laminar architecture using manganese-enhanced MRI

    • Author(s)
      Silva AC, Lee JH, Wu CW, Tucciarone J, Pelled G, Aoki I
    • Journal Title

      J Neurosci Methods 30;167(2)

      Pages: 246-257

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 高磁場MRIによる分子イメージングへのアプローチ2008

    • Author(s)
      青木 伊知男
    • Organizer
      第1回創薬とイメージングに関するシンポジウム
    • Place of Presentation
      大阪市
    • Year and Date
      2008-02-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Multimodal Thermosensitive Polymer-Modified Liposome (MTPL) as a Carrier for MRI and Optical Imaging2008

    • Author(s)
      Ichio Aoki, Misao Yoneyama, Jun Hirose, Yuzuru Minemoto, Takayoshi Koyama, Sadahito Aoshima, Jeff Kershaw, Kenji Kono, Yukihito Ishizaka, Iwao Kanno
    • Organizer
      2008 World Molecular Imaging Congress 1569
    • Place of Presentation
      Nice, France
    • Related Report
      2008 Final Research Report
  • [Presentation] In Vivo Optical and Magnetic Resonance Imaging of Electroporation-Mediated Transgene Expression in Experimental Tumors2008

    • Author(s)
      Winn Aung, Sumitaka Hasegawa, Michiko Koshikawa, Takayuki Obata, Hiroo Ikehira, Takako Furukawa, Ichio Aoki, Tsuneo Saga.
    • Organizer
      2008 World Molecular Imaging Congress, 698
    • Place of Presentation
      Nice, France
    • Related Report
      2008 Final Research Report
  • [Presentation] In-Vivo Application of Manganese-Labeled Immunocytes2008

    • Author(s)
      Kenichi Odaka, Ichio Aoki, Junji Moriya, Kaoru Tateno, Hiroyuki Tadokoro, Tohru Minamino, Toshiaki Irie, Issei Komuro, Kanno Iwao
    • Organizer
      2008 World Molecular Imaging Congress, 1034
    • Place of Presentation
      Nice, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Exploring Molecular Targets for Mesothelioma Imaging2008

    • Author(s)
      Michiko Koshikawa, Sumitaka Hasegawa, Isao Takahashi, Misao Hachiya, Takako Furukawa, Makoto Akashi, Satoshi Yoshida, Ichio Aoki, Tsuneo Saga
    • Organizer
      2008 World Molecular Imaging Congress, 1141
    • Place of Presentation
      Nice, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Compartmentalized Diffusion-Weighted Fmri Signal in Alpha-Chloralose Anesthetized Rat Somatosensory Cortex at 7 T2008

    • Author(s)
      Joonas A. Autio, Jeff Kershaw, Takayuki Obata, Sayaka Shibata, Daigo Kuroiwa, Iwao Kanno, Ichio Aoki
    • Organizer
      2008 World Molecular Imaging Congress, 1918
    • Place of Presentation
      Nice, France
    • Related Report
      2008 Final Research Report
  • [Presentation] Quantum Dots in Multimodal Imaging: Probe Design, Spectral Characteristics, and Application2008

    • Author(s)
      Zhivko Zhelev, Bakalova Rumiana, Aoki Ichio, Gadjeva Veselina, Kanno Iwao
    • Organizer
      2008 World Molecular Imaging Congress, 1595
    • Place of Presentation
      2008 World Molecular Imaging Congress, 1595
    • Related Report
      2008 Final Research Report
  • [Presentation] Multimodal Molecular Probes: Chemical Design, Spectral Characteristics and Application for In Vitro and In Vivo Imaging2008

    • Author(s)
      Rumiana Bakalova, Zhivko Zhelev, 青木伊知男, 松本謙一郎, Veselina Gadjeva, 安西和紀, 菅野 巖
    • Organizer
      第3回日本分子イメージング学会
    • Place of Presentation
      埼玉
    • Related Report
      2008 Final Research Report
  • [Presentation] 温度感受性リポソームによるMRI/蛍光の複合機能プローブの開発-腫瘍検出、薬剤放出の可視化、化学療法のために2008

    • Author(s)
      青木伊知男、米山 操、廣瀬 淳、峯本 譲、小山貴芳、青島貞人、Jeff Kershaw、河野健司、石坂幸人、菅野 巖
    • Organizer
      第3回日本分子イメージング学会
    • Place of Presentation
      埼玉
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス実験腫瘍へのエレクトロポレーションによる遺伝子導入とその遺伝子発現のin vivo MRI/蛍光イメージング2008

    • Author(s)
      長谷川純崇、Winn Aung、米山操、越川道子、楢崎美智子、小畠隆行、古川高子、青木伊知男、佐賀恒夫
    • Organizer
      第3回日本分子イメージング学会
    • Place of Presentation
      埼玉
    • Related Report
      2008 Final Research Report
  • [Presentation] 血管新生モニタリングのための磁気共鳴イメージング造影剤の作成2008

    • Author(s)
      城潤一郎、林 雪、米山操、柴田さやか、青木伊知男、田畑泰彦
    • Organizer
      第3回日本分子イメージング学会
    • Place of Presentation
      埼玉
    • Related Report
      2008 Final Research Report
  • [Presentation] Thermosensitive Polymer-modified Liposome as a Multimodal and Multifunctional Carrier for MRI and Optical Imaging : Tumor Detection, Visualization of Triggered Drug Release, and Chemotherapy2008

    • Author(s)
      Ichio Aoki, Misao Yoneyama, Jeffrey Kershaw, Iwao Kanno, et. al
    • Organizer
      ISMRM 16th Scientific Meeting and Exhibition
    • Place of Presentation
      Tront, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] A social eating party induced affiliation behavior of chick reared in socially deprived condition2008

    • Author(s)
      Mamiko Koshiba, Takashi Ogino, Ichio Aoki, et. al.
    • Organizer
      CINP Pacific-Asia Regional Meeting
    • Place of Presentation
      Kuala Lumpur,Malaysia
    • Related Report
      2007 Annual Research Report
  • [Presentation] マンガン増感MRI(MEMRI)によるラット前肢末梢神経経路トレーシング2007

    • Author(s)
      青木伊知男、Afonso Silva、Alan Koretsky
    • Organizer
      第35回日本磁気共鳴医学会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] マンガン増感MRIによる移植細胞標識の試み2007

    • Author(s)
      小高謙一、青木伊知男、米山 操、森谷純治、舘野 馨、田所 裕之、南野 徹、小室一成、入江俊章、鈴木和年、菅野 巖
    • Organizer
      第35回日本磁気共鳴医学会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 社会性コミュニケーション行動に関与する脳領域の7T MRIによる解析2007

    • Author(s)
      小柴満美子、荻野孝史、青木伊知男、池平博夫、菅野 巖、中村 俊
    • Organizer
      第35回日本磁気共鳴医学会大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] Polymer coating of quantum dots is crucial for their in vivo optical imaging application2007

    • Author(s)
      Bakalova R, Masamoto K, Zhelev Z, Aoki I, Obata T, Kanno I
    • Organizer
      Joint Molecular Imaging Conference 0366
    • Place of Presentation
      Providence, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 複合イメージングと生物学診断のためのカンタムドットを利用した分子プローブについて2007

    • Author(s)
      Bakalova Rumiana、Zhivko Zhelev、青木伊知男、Genoveva Zlateva、小畠隆行、菅野 巖
    • Organizer
      第2回日本分子イメージング学会学術集会
    • Place of Presentation
      福井
    • Related Report
      2008 Final Research Report
  • [Presentation] 高速・定量値マッピングのマンガン増感MRIへの適用2007

    • Author(s)
      米山 操、Jeff Kershaw、菅野 巖、青木伊知男
    • Organizer
      第2回日本分子イメージング学会学術集会
    • Place of Presentation
      福井
    • Related Report
      2008 Final Research Report
  • [Presentation] マンガン増感MRIによる移植免疫細胞の標識技術の開発2007

    • Author(s)
      小高謙一、青木伊知男、米山 操、森谷純治、舘野 馨、田所 裕之、南野 徹、小室一成、入江俊章、鈴木和年、菅野 巖
    • Organizer
      第2回日本分子イメージング学会学術集会
    • Place of Presentation
      福井
    • Related Report
      2008 Final Research Report
  • [Presentation] Detection of Reactive Gliosis using Manganese-enhanced MRI (MEMRI). International Society for Magnetic Resonance in Medicine2007

    • Author(s)
      Y. Kawai, I. Aoki, N. Matsumoto, M. Umeda, T. Higuchi, J. Kershaw, A. C. Silva, C. Tanaka
    • Organizer
      Scientific Meeting and Exhibition
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] Thermosensitive Polymer-Modified Liposome as a Multimodal and Multifunctional Carrier for MRI and Optical Imaging: Tumor Detection, Visualization of Triggered Drug Release, and Chemotherapy2007

    • Author(s)
      Aoki I, Yoneyama M, Hirose J, Minemoto Y, Koyama T, Aoshima S, Kershaw J, Kono K, Ishizaka Y, Kanno I.
    • Organizer
      International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
    • Related Report
      2008 Final Research Report
  • [Presentation] マンガン増感MRIによる移植細胞標識の試み2007

    • Author(s)
      小高 謙一、青木 伊知男, ら
    • Organizer
      第35回日本磁気共鳴医学会大会
    • Place of Presentation
      神戸市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantum Dot-Based Nanobioprobes for Multimodal Imaging and Biomedical Diagnostics2007

    • Author(s)
      Rumiana Bakalova-Zheleva, Zhivko Zhelev, Ichio Aoki, et. al.
    • Organizer
      EuroNanoForum2007
    • Place of Presentation
      Dusseldorf,Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantum dot-based nanobioprobes for multimodal imaging and biomedical diagnostics2007

    • Author(s)
      Rumiana Bakalova-Zheleva, Zhivko Zhelev, Ichio Aoki, et. al.
    • Organizer
      2nd International Symposium Advanced micro-and mesoporous materials
    • Place of Presentation
      Varna,Bulgaria
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantum dot-based molecular probes for multimodal imaging and biomedical diagnostics2007

    • Author(s)
      Rumiana Bakalova-Zheleva, Zhivko Zhelev, Ichio Aoki
    • Organizer
      第2回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      福井市
    • Related Report
      2007 Annual Research Report
  • [Presentation] Polymer coating of quantum dots is crucial for their in vivo optical imaging application2007

    • Author(s)
      Rumiana Bakalova-Zheleva, Kazuto Masamoto, Zhivko Zhelev, Ichio Aoki, et. al.
    • Organizer
      Joint Molecular Imaging Conference2007
    • Place of Presentation
      Providence,USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高磁場磁気共鳴画像法による細胞・分子イメージング〜マンガン増感MRI(MEMRI)を中心に〜2007

    • Author(s)
      青木 伊知男
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] マンガン増感MRI(MEMRI)によるラット前肢末梢神経経路トレーニング2007

    • Author(s)
      青木 伊知男, ら
    • Organizer
      第35回日本磁気共鳴医学会大会
    • Place of Presentation
      神戸市
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高速・定量値マッピングのマンガン増感MRIへの適用2007

    • Author(s)
      米山 操、Kershaw Jeffrey、菅野 巖、青木 伊知男
    • Organizer
      第2回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      福井市
    • Related Report
      2007 Annual Research Report
  • [Book] Bakalova Rumian.DDSによる「MR分子イメージング」へ(in press)2008

    • Author(s)
      青木伊知男
    • Publisher
      Drug Delivery System
    • Related Report
      2008 Final Research Report
  • [Book] 動物用MRイメージング計測、ますます広がる分子イメージング技術 : 生物医学研究から先端医療、創薬研究までを支える分子イメージング技術(in press)2008

    • Author(s)
      青木伊知男
    • Publisher
      遺伝子医学MOOK ; 9
    • Related Report
      2008 Final Research Report
  • [Book] Rumiana Bakalova、DDS による「MR分子イメージング」へ、Drug Delivery System、分子イメージングとDDS、総説、23(1)2008

    • Author(s)
      青木伊知男
    • Related Report
      2008 Final Research Report
  • [Book] .MRIによる分子イメージングの研究動向50(12)2007

    • Author(s)
      青木伊知男
    • Publisher
      放射線科学
    • Related Report
      2008 Final Research Report
  • [Book] 動物用MRイメージング計測、遺伝子医学MOOK9号「生物医学研究から先端医療、創薬研究までを支える分子イメージング技術」、第1章、2.MRIによる分子イメージングISBN978-4-944157-39-6

    • Author(s)
      青木伊知男
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.nirs.go.jp/research/division/mic/group/g_sentan-seitai-th.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 常磁性金属含有ポリアミドアミンデンドロン脂質2008

    • Filing Date
      2008-04-25
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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