Development of accurate computer-aided diagnosis of pulmonary nodules in x-ray CT images by using multi-scale morphological recognition

• Project/Area Number: 19500413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: HOMMA Noriyasu Tohoku University, サイバーサイエンスセンター, 准教授 (30282023)
• Co-Investigator(Kenkyū-buntansha): 石橋 忠司 東北大学, 医学部, 教授 (40151401)
• Co-Investigator(Renkei-kenkyūsha): ISHIBASHI Tadashi 東北大学, 大学院・医学系研究科, 教授 (40151401)
• Research Collaborator: GUPTA Madan Department of Engineering, University of Saskatchewan, Professor Emeritus
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 検査・診断システム / 知的画像診断 / 診断支援システム

Research Abstract

In this research project, we developed a new intelligent method for computer aided detection of pulmonary nodules in x-ray CT images. An essential core of the method is to use some pieces of radiologist's professional knowledge to achieve clinically demanded high detection accuracy. The results demonstrated that the method can improve 30% of true positive rate for hardly-detectable nodules and reduce 40% of false positive rate compared to previous ones.

Research Products

• [Journal Article] A Study on Effect of Morphological Filters on Computer-aided Medical Image Diagnosis (2009)
  • Author(s): Noriyasu Homma, Yuko Kawai, Satoshi Shimoyama, Tadashi Ishibashi, Makoto Yoshizawa
  • Journal Title: Artificial Life and Robotics Vol.14, No.2 Pages: 191-194
• [Journal Article] Dynamic Backpropagation (in Czech) (2009)
  • Author(s): Ivo Bukovsky, Noriyasu Homma
  • Journal Title: Automatizace Vol.52, No.10 Pages: 586-590
• [Journal Article] Lung Area Extraction from X-ray CT Images for Computer-aided Diagnosis of Pulmonary Nodules by using Active Contour Model (2009)
  • Author(s): Noriyasu Homma, Satoshi Shimoyama, Tadashi Ishibashi, Makoto Yoshizawa
  • Journal Title: WSEAS Trans.Information Science & Applications Vol.6, Issue 5 Pages: 746-755
• [Journal Article] A New Motion Management Method for Lung Tumor Tracking Radiation Therapy (2009)
  • Author(s): Noriyasu Homma
  • Journal Title: WSEAS Trans.Systems 8 Pages: 471-480
  • Peer Reviewed
• [Journal Article] Lung Area Extraction from X-ray CT Images for Computer-aided Diagnosis of Pulmonary Nodules by using Active Contour Model (2009)
  • Author(s): Noriyasu Homma
  • Journal Title: WSEAS Trans.Inform.Science & Applications 6 Pages: 746-755
  • Peer Reviewed
• [Journal Article] Dynamic backpropagation (2009)
  • Author(s): Ivo Bukovsky
  • Journal Title: Automatizace 10 Pages: 586-590
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Noriyasu Homma
  • Journal Title: Pattern Recognition(In-Tech) Pages: 319-336
• [Journal Article] (2009)
  • Author(s): Ivo Bukovsky
  • Journal Title: Discoveries and Breakthroughs in Cognitive Informatics and Natural Intelligence(IGI Publishing) Pages: 508-523
• [Journal Article] Human Brain Activities Related to Manual Control of a Nonholonomic System : An f-MRI Study (2009)
  • Author(s): Noriyasu Homma
  • Journal Title: International Journal of Advanced Computer Engineering (印刷中)
  • Peer Reviewed
• [Journal Article] A Study on Effect of Morphological Filters on Computer-aided Medical Image Diagnosis (2009)
  • Author(s): Noriyasu Homma
  • Journal Title: Artificial Life and Robotics (印刷中)
  • Peer Reviewed
• [Journal Article] Combinatorial Effect of Various Features Extraction on Computer Aided Detection of Pulmonary Nodules in X-ray CT Images (2008)
  • Author(s): Noriyasu Homma, Kazunori Takei, Tadashi Ishibashi
  • Journal Title: WSEAS Trans.Information Science & Applications Vol.5, Issue 7 Pages: 1127-1136
• [Journal Article] Combinatorial Effect of Various Features Extraction on Computer Aided Detection of Pulmonary Nodules in X-ray CT Images (2008)
  • Author(s): Noriyasu Homma
  • Journal Title: WSEAS Trans. Information Science and Applications 5 Pages: 1127-1136
  • Peer Reviewed
• [Journal Article] 形状的特徴量抽出に基づく胸部X線CT画像における肺結節陰影パターンの自動鑑別 (2008)
  • Author(s): 武井 一典
  • Journal Title: 知能と情報 20 Pages: 108-116
  • Peer Reviewed
• [Journal Article] A New Method for Computer Aided Detection of Pulmonary Nodules in X-ray CT Images (2008)
  • Author(s): Noriyasu Homma
  • Journal Title: Proc. 7th WSEAS Int'1. Conf. on Artificial Intelligence, Knowledge Engineering and Data Bases 1 Pages: 379-384
  • Peer Reviewed
• [Journal Article] Computer Aided Diagnosis for Pulmonary Nodules by Shape Feature Extraction (2007)
  • Author(s): Kazunori Takei
  • Journal Title: Proc. of SICE 2007 (CD-ROM) Pages: 1964-1967
  • Peer Reviewed
• [Presentation] Sensitivity improvement of automatic pulmonary nodules detection in chest X-ray CT images (2010)
  • Author(s): S. Shimoyama, N. Homma, T. Ishibashi, M. Yoshizawa
  • Organizer: 15^<th> AROB'10
  • Place of Presentation: Beppu, Japan
  • Year and Date: 2010-02-05
• [Presentation] Sensitivity improvement of automatic pulmonary nodules detection in chest X-ray CT images (2010)
  • Author(s): Satoshi Shimoyama
  • Organizer: Prof.AROB 2010
  • Place of Presentation: 別府Bコンプラザ(大分県)
  • Year and Date: 2010-02-05
• [Presentation] Auto-Detection of Non-Isolated Pulmonary Nodules Connected to The Chest Walls in X-ray CT images (2009)
  • Author(s): Satoshi Shimoyama, Noriyasu Homma, Masao Sakai, Tadashi Ishibashi, Makoto Yoshizawa
  • Organizer: ICROS-SICE2009
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2009-08-20
• [Presentation] Auto-Detection of Non-Isolated Pulmonary Nodules Connected to The Chest Walls in X-ray CT Images (2009)
  • Author(s): Satoshi Shimoyama
  • Organizer: Prof.ICROS-SICE 2009
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2009-08-20
• [Presentation] Auto-Detection of Non-Isolated Pulmonary Nodules in X-ray CT Images (2009)
  • Author(s): N. Homma, S. Shimoyama, M. Sakai, T. Ishibashi, M. Yoshizawa
  • Organizer: 8th AIKED'09
  • Place of Presentation: Cambridge, U.K.
  • Year and Date: 2009-02-22
• [Presentation] A study on effect of morphological filters on computer-aided medical image diagnosis (2009)
  • Author(s): Noriyasu Homma, Yuko Kawai, Satoshi Shimoyama, Tadashi Ishibashi, Makoto Yoshizawa
  • Organizer: 14^<th> AROB'09
  • Place of Presentation: Beppu, Japan
  • Year and Date: 2009-02-06
• [Presentation] Fuzzy Neural Computing Systems : Theory and Applications (2008)
  • Author(s): Madan M. Gupta, Noriyasu Homma, Zeng-Guang Hou, Ashu M. G. Solo
  • Organizer: Tutorial for IEEE ICAL
  • Place of Presentation: Qingdao, China
  • Year and Date: 2008-08-31
• [Presentation] Shape Features Extraction from Pulmonary Nodules in X-ray CT Images (2008)
  • Author(s): N. Homma, K. Saito, T. Ishibashi, M. M. Gupta, Z.-G. Hou, A. M. G. Solo
  • Organizer: World Congress on Computational Intelligence
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2008-06-06
• [Presentation] Shape Features Extraction from Pulmonary Nodules it X-ray CT Images (2008)
  • Author(s): Noriyasu Homma
  • Organizer: World Congress on Computational Intelligence
  • Place of Presentation: 香港(中国)
  • Year and Date: 2008-06-06
• [Presentation] A new method for computer aided detection of pulmonary nodules in x-ray CT images (2008)
  • Author(s): Noriyasu Homma, Kazunori Takei, Tadashi Ishibashi
  • Organizer: 7^<th> AIKED' 08
  • Place of Presentation: Cambridge, U.K.
  • Year and Date: 2008-02-20
• [Presentation] X線CT画像における肺結節陰影の統計的特徴量に関する一考察 (2007)
  • Author(s): 齋藤 和久
  • Organizer: 計測自動制御学会東北支部第240回研究集会
  • Place of Presentation: 多賀城市(東北学院大学)
  • Year and Date: 2007-12-18
• [Presentation] Computer Aided Diagnosis for Pulmonary Nodules by Shape Feature Extraction (2007)
  • Author(s): K. Takei, N. Homma, T. Ishibashi, M. Sakai, M. Yoshizawa
  • Organizer: SICE 2007
  • Place of Presentation: Takamatsu, Japan
  • Year and Date: 2007-09-20
• [Book] Artificial Higher Order Neural Networks for Computer Science and Engineering, Information Science Reference(Ming Zhang (Ed)) (2010)
  • Author(s): Madan M. Gupta, Noriyasu Homma, Zeng-Guang Hou, Ashu M. G. Solo, Ivo Bukovsky
  • Publisher: Hershey
• [Book] Artificial Higher Order Neural Networks for Computer Science and Engineering (2010)
  • Author(s): Madan M.Gupta
  • Publisher: Information Science Reference(In press)
• [Book] Discoveries and Breakthroughs in Cognitive Informatics and Natural Intelligence (2009)
  • Author(s): Bukovsky, I., Bila. J, Gupta, M., M, Hou, Z-G., Homma, N.
  • Publisher: IGI Publishing
• [Book] Pattern Recognition (2009)
  • Author(s): Noriyasu Homma
  • Publisher: In-Tech
• [Book] Artificial Higher Order Neural Networks for Economics and Business, Information Science Reference(Ming Zhang (Ed)) (2008)
  • Author(s): Madan M. Gupta, Noriyasu Homma, Zeng-Guang Hou, Ashu M. G. Solo, Takakuni Goto
  • Publisher: Hershey
• [Book] Artificial Higher Order Neural Networks for Economics and Business (2008)
  • Author(s): Madan M. Gupta
  • Publisher: Information Science Reference
• [Book] 診療画像マスター・テキスト (2008)
  • Author(s): 石橋 忠司, 他監修
  • Publisher: メジカルビュー社(印刷中)
• [Patent(Industrial Property Rights)] 画像診断支援システム、画像診断支援方法および画像診断支援プログラム (2007)
  • Inventor(s): 本間経康, 武井一典, 石橋忠司, 酒井正夫, 吉澤誠
  • Industrial Property Rights Holder: 株式会社イメージワン, 国立大学法人東北大学
  • Industrial Property Number: 2007-134230
  • Filing Date: 2007-05-21
• [Patent(Industrial Property Rights)] 画像診断支援システム、画像診断支援方法および画像診断支援プログラム (2007)
  • Inventor(s): 本間 経康
  • Industrial Property Rights Holder: 東北大学, (株)イメージワン
  • Industrial Property Number: 2007-134230
  • Filing Date: 2007-05-21