Biomarkers for the evaluation of lung remodeling using CT volume data
| Project/Area Number |
19500421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
TOMIYAMA Noriyuki Osaka University, 医学系研究科, 准教授 (50294070)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Osamu 大阪大学, 医学系研究科, 助教 (80324755)
OGATA Yuji 大阪大学, 医学系研究科, 助教 (60281127)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 胸部CT / バイオマーカー / 肺リモデリング / 画像解析 / リモデリング / 全肺thin-section volume CT / COPD / 喘息 / 慢性間質性肺炎 / 3次元画像解析 |
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| Research Abstract |
The purpose of this study is to find biomarkers for the evaluation of lung remodeling using CT volume data of lung focal volume and endobronchial volume. At first, we developed computer segmentation software to divide lung field into lobes for this purpose. Using this software lung focal volume and endobronchial volume were calculated and correlated with clinical findings and lung function tests. As a result, it was found that lung focal volume and endobronchial volume were increased in progression of obstructive lung disease, and these were decreased in progression of interstitial lung disease. It was suggested that these parameters could be robust biomarkers for the evaluation of lung remodeling in the clinical trial and routine clinical settings.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Nonspecific interstitial pneumonia: histologic correlation with high-resolution CT in 29 patients.2009
Author(s)
Sumikawa H, Johkoh T, Ichikado K, Taniguchi H, Kondoh Y, Fujimoto K, Yanagawa M, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H, Colby TV.
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Journal Title
Eur J Radiol. 70
Pages: 35-40
Related Report
Peer Reviewed
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[Journal Article] Computed tomography findings in pathological usual interstitial pneumonia: relationship to survival.2008
Author(s)
Sumikawa H, Johkoh T, Colby TV, Ichikado K, Suga M, Taniguchi H, Kondoh Y, Ogura T, Arakawa H, Fujimoto K, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H, Muller NL.
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Journal Title
Am. J. Respir.. Crit. Care. Med. 177
Pages: 433-439
Related Report
Peer Reviewed
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[Journal Article] Pulmonary adenocarcinomas with ground-glass attenuation on thin-sectionCT: Quantification by three-dimensional image analyzing method.2007
Author(s)
Sumikawa H, Johkoh T, Nagareda T, Sekiguchi J, Matsuo K, Fujita Y, Natsag J, Inoue A, Mihara N, Honda O, Tomiyama N, Minami M, Okumura M, Nakamura H.
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Journal Title
Eur. J. Radiol. 65
Pages: 104-111
Related Report
Peer Reviewed
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[Journal Article] Volume histogram analysis for lung thin-section computed tomography: differentiation between usual interstitial pneumonia and nonspecific interstitial pneumonia.2007
Author(s)
Sumikawa H, Johkoh T, Yamamoto S, Oota M, Ueguchi T, Ogata Y, Matsumoto M, Fujita Y, Natsag J, Inoue A, Mihara N, Honda O, Tomiyama N, Nakamura H.
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Journal Title
J. Comput. Assist. Tomogr. 31
Pages: 936-942
Related Report
Peer Reviewed
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[Presentation] Pulmonary cysts, airway dimensions, respiratory functional abnormalities and prognosis; Quantitative analysis of volumetric CT data in 30 patients with lymphangioleiomyomatosis.2009
Author(s)
Tobino K, Johkoh T, Seyama K, Kurihara M, Kikuyama A, Yanagawa M, Inoue A, Sumikawa H, Honda O, Koyama M, Yoshida S, Tomiyama N, Takahashi K.
Organizer
Radiological Society of North America 95th Scientific Assembly and Annual Meeting (RSNA'09)
Place of Presentation
Chicago, Illinoi, U.S.A.
Related Report
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