Less invasive tumor ablation therapy of liver cancers with a navigation system based on simultaneous use of open MRI and ultrasound

• Project/Area Number: 19500422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Kyushu University
• Principal Investigator: NAKASHIMA Hideaki Kyushu University, 医学研究院, 研究員 (20253528)
• Co-Investigator(Kenkyū-buntansha): HASHIZUME Makoto 九州大学, 医学研究院, 教授 (90198664) ; TANOUE Kazuo 九州大学, 大学病院, 准教授 (40294920) ; KONISHI Kozo 九州大学, 医学研究院, 寄附講座教員 (90380641) ; 洪 在成 九州大学, 先端融合医療レドックスナビ研究拠点, 学術研究員 (70404043) ; 遠城寺 宗近 九州大学, 大学病院, 助教 (20253411)
• Co-Investigator(Renkei-kenkyūsha): HONG Jaesung 九州大学, 先端融合医療レドックスナビ研究拠点, 学術研究員 (70404043)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌 / バーチャルリアリティ / 低侵襲治療 / 画像誘導

Research Abstract

Image guided ablation therapy of liver cancers based on simultaneous use of open MRI and ultrasound (US) was proposed to improve safety and accuracy of the treatment. Phantom and animal experiments revealed errors were only 2-3mm using both MRI and US. The ablation therapy was performed for 51 liver tumors in 34 patients and punctures into tumors were successful in all cases. No mortality or major complications were occurred. The present system using both MRI and US allows a safe and accurate approach to liver cancers.

Research Products

• [Journal Article] Tumor ablation therapy of liver cancers with an open magnetic resonance imaging-based navigation system (2009)
  • Author(s): Maeda T, Hong J, Konishi K, Nakatsuji T, Yasunakga T, Yamashita Y, Taketomi A, Kotoh K, Enjoji M, Nakashima H, Tanoue K, Maehara Y, Hashizume M
  • Journal Title: Surgical Endoscopy 23 Pages: 1048-1053
• [Journal Article] ashizume M Medical navigation system for otologic surgery based on hybrid registration and virtual intraoperative computed tomography IEEE (2009)
  • Author(s): Hong J, Matsumoto N, Ouchida R, Komune S
  • Journal Title: Transactions on Biomedical Engineering 56 Pages: 426-432
• [Journal Article] Medical navigation system for otologic surgery based on hybrid registration and virtual intraoperative computed tomography (2009)
  • Author(s): Hong J, Matsumoto N, Ouchida R, Komune S, Hashizume M
  • Journal Title: IEEE Transactions on Biomedical Engineering 56 Pages: 426-432
  • Peer Reviewed
• [Journal Article] 療計画と複数ナビゲーションの統合によるMRI誘導下突刺術の精度向上 (2008)
  • Author(s): 仲本秀和、安永武史、橋爪誠、伊関洋治
  • Journal Title: J JSCAS 10 Pages: 45-52
• [Journal Article] Tumor ablation therapy of liver cancers with an open magnetic resonance imaging-based navigation system. (2008)
  • Author(s): Maeda T, Hong J, Konishi K, Nakatsuji T, et al.
  • Journal Title: Surgical Endoscopy (in press)
  • Peer Reviewed
• [Journal Article] 治療計画と複数ナビゲーションの統合によるMRI誘導下突刺術の精度向上 (2008)
  • Author(s): 仲本 秀和, 安永 武史, 橋爪 誠, 伊関 洋
  • Journal Title: J JSCAS vol. 10 no. 1 Pages: 45-52
  • Peer Reviewed
• [Journal Article] 巻頭言 OpenMRIを用いた画像誘導下治療への道 (2008)
  • Author(s): 橋爪 誠
  • Journal Title: MEDIX49株式会社日立メディコ 49 Pages: 2-3
• [Journal Article] MRI画像誘導下の超精密ロボット手術の臨床応用を目指して (2008)
  • Author(s): 家入 里志, 橋爪 誠
  • Journal Title: MEDIX49 株式会社日立メディコ 49 Pages: 4-9
• [Journal Article] Assessment of anterolateral rotatory instability in the anterior cruciate ligament-deficient knee using an open Magnetic resonance imaging system. (2007)
  • Author(s): Okazaki K, Miura H, Matsuda S, Yasunaga T, Nakashima H, Konishi K, Iwamoto Y, Hashizume M, et al.
  • Journal Title: Am J Sports Med 35 Pages: 1091-97
• [Journal Article] MR-compatible laparoscope with a distally mounted CCD for MR image-guided surgery. (2007)
  • Author(s): Yasunaga T, Konishi K, Yamaguchi S, Okazaki K, Hong J-s, Ieiri S, Nakashima H, Tanoue K, Fukuyo T, Hashizume M, et al.
  • Journal Title: Int J CARS 2 Pages: 11-18
• [Journal Article] Assessment of anterolateral rotatory instability in the anterior cruciate ligament-deficient knee using an open Magnetic resonance imaging system (2007)
  • Author(s): Okazaki K, Nakashima H, Konishi K, Hashizume M, et. al.
  • Journal Title: Am J Sports Med 35 Pages: 1091-1097
  • Peer Reviewed
• [Journal Article] MR-compatible laparoscope with a distally mounted CCD for MR image-guided surgery (2007)
  • Author(s): Yasunaga T, Konishi K, Hong J-s, Ieiri S, Nakashima H, Hashizume M, et. al.
  • Journal Title: Int J CARS 2 Pages: 11-18
  • Peer Reviewed
• [Presentation] Open MRIシステムを応用したリアルタイム3次元ナビゲーションによる肝癌の局所治療 (2009)
  • Author(s): 富川盛雅、洪在成、小西晃造、東真弓、前田貴司、杉町圭史、祇園智信、武冨紹信、古藤和浩、家入里志、田上和夫、前原喜彦、橋爪誠
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] Open MRIを応用したリアルタイム3次元ナビゲーションシステムによる肝癌の局所治療 (2009)
  • Author(s): 富川盛雅、洪在成、小西晃造、杉町圭史、祇園智信、武冨紹信、家入里志、田上和夫、前原喜彦、橋爪誠
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] Open MRI治療室で行う内視鏡外科手術とその環境整備 (2009)
  • Author(s): 富川盛雅、小西晃造、赤星朋比古、洪在成、家入里志、田上和夫、前原喜彦、橋爪誠
  • Organizer: 第22回日本内視鏡外科学会総会
  • Place of Presentation: 東京
• [Presentation] Open MRIを用いた肝癌の局所治療におけるナビゲーションシステムの導入 (2008)
  • Author(s): 前田貴司、洪在成、小西晃造、吉田大輔, 古藤和浩、遠城寺宗近、武冨紹信、中辻隆徳、家入里志、田上和夫、前原喜彦、橋爪誠
  • Organizer: 第108回日本外科学会定期学術集会
• [Presentation] オープンMRIを用いた再発肝癌に対する局所治療 (2008)
  • Author(s): 前田貴司、小西晃造、武富紹信、古藤和浩、遠城寺宗近、前原喜彦、橋爪誠
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
• [Presentation] Open MRI guided surgical navigation system for percutaneous needle insertion therapy. (2008)
  • Author(s): Hong J-s, Maeda T, Yamashita Y, Nakashima H, Kotoh K, Enjoji M, Yasunaga T, Taketomi A, Ieiri S, Konishi K, Tanoue K, Maehara Y, Hashizume M
  • Organizer: The 4th International Workshop on Medical Imaging and Augmented Reality(MIAR2008)
  • Place of Presentation: Japan
• [Presentation] Interventional MRI navigation for liver tumour ablation. (2008)
  • Author(s): Hong J, Maeda T, Yamashita T, Nakashima H, et al.
  • Organizer: 7^<th> Asian-Pacific Conference on Medical and Biological Engineering (ACCAS2008)
  • Place of Presentation: Beijing, China
• [Presentation] Open MRIを用いた肝癌の局所治療におけるナビゲーションシステムの導入 (2008)
  • Author(s): 前田貴司, 洪在成, 小西晃造, 他
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 画像誘導下内視鏡治療の現況 (2008)
  • Author(s): 橋爪 誠
  • Organizer: 第7回国際バイオフォーラム
  • Place of Presentation: 東京
• [Presentation] Open MRI guided surgical navigation system for percutaneous needle in sertion therapy. (2008)
  • Author(s): Hong J, Maeda T, Yamashita Y, Nakashima H, et al.
  • Organizer: The 4^<th> International Workshop on Medical Imaging and Augmented Reality(MIAR2008).
  • Place of Presentation: Tokyo, Japan
• [Presentation] Open MRIと超音波を統合した三次元画像誘導システムの開発と肝癌経皮的局所治療への応用 (2007)
  • Author(s): 中島秀彰、洪在成、遠城寺宗近、前原喜彦、橋爪誠
  • Organizer: 第62回日本消化器外科学会定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-18
• [Presentation] 肝癌に対する局所治療におけるOpen MRIと超音波とを統合した画像誘導治療システムの導入 (2007)
  • Author(s): 中島秀彰、洪在成、小西晃造、古藤和浩、遠城寺宗近、前原喜彦、橋爪誠
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-01
• [Presentation] コンピュータ支援による三次元画像誘導を取り入れた次世代外科手術 (2007)
  • Author(s): 小西晃造、掛地吉弘, 吉野一郎、川中博文、森田勝、沖英次、田上和夫、中島秀彰、橋爪誠、前原喜彦
  • Organizer: 第107回日本外科学会定期学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2007-04-13
• [Book] Navigation Surgery跡見裕(編)消化器外科学レビュー2007 (2007)
  • Author(s): 中島秀彰、橋爪誠
  • Publisher: 総合医学社