Study of sentinel node detection method using contrast-enhanced ultrasonography with second generation of ultrasound contrast agent in malignant tumor

• Project/Area Number: 19500424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Jichi Medical University
• Principal Investigator: OMOTO Kiyoka Jichi Medical University, 医学部, 准教授 (90306118)
• Co-Investigator(Kenkyū-buntansha): TANIGUCHI Nobuyuki 自治医科大学, 医学部, 教授 (10245053) ; HOZUMI Yasuo 自治医科大学, 医学部, 准教授 (50260831)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 第2世代超音波造影剤 / ソナゾイド / センチネルリンパ節 / 乳癌 / 超音波造影法 / 超音波造影剤 / 造影超音波画像 / 臨床研究 / 次世代超音波造影剤 / 悪性腫瘍 / 腋窩リンパ節郭清

Research Abstract

This study aimed to evaluate the usefulness of sentinel lymph node (SLN) detection in breast cancer using contrast-enhanced ultrasonography with Sonazoid. More than 100 breast cancer patients were examined in our hospital. After 2 ml of Sonazoid was injected subareolarly, the axillary area was observed transdermally using ultrasonography with linear transducer. A contrast-enhanced SLN was seen within 5 min, and its detection rate was more than 80%. Moreover the SLN detection rate was compared with that of other methods and resected SLNs were evaluated pathologically. It is suggested that our new method is clinically useful for sentinel node identification.

Research Products

• [Journal Article] Sentinel node detection method using contrast-enhanced ultra-sonography with Sonazoid in breast cancer: Preliminary clinical study (2009)
  • Author(s): Omoto K, Matsunaga H, Take N, Hozumi Y, Takehara M, Omoto Y, Shiozawa M, Mizunuma H, Harashi-ma H, Taniguchi N, Kawano M
  • Journal Title: Ultrasound Med Biol 35 Pages: 1249-1256
  • Peer Reviewed
• [Journal Article] ソナゾイドを用いた造影超音波画像による乳癌のセンチネルリンパ節同定法 (2009)
  • Author(s): 尾本きよか
  • Journal Title: 映像情報メディカル 41(5) Pages: 552-555
• [Journal Article] ソナゾイド乳輪下注入による造影超音波画像を用いたセンチネルリンパ節の新たな同定法 (2009)
  • Author(s): 尾本きよか
  • Journal Title: インナービジョン 24(6) Pages: 82-84
• [Journal Article] Sentinel node detection method using contrast-enhanced ultrasonography with Sonazoid in breast cancer : Preliminary clinical study (2009)
  • Author(s): Omoto K, Matsunaga H, Take N, Hozumi Y, Takehara M, Omoto Y, Shiozawa M, Mizunuma H, Harashima H, Taniguchi N, Kawano M
  • Journal Title: Ultrasound Med Biol 35 Pages: 1249-1256
  • Peer Reviewed
• [Presentation] 造影超音波画像による乳癌センチネルリンパ節同定法の研究 (2009)
  • Author(s): 尾本きよか、河野幹彦、松永宏明、竹夏樹、谷口信行、穂積康夫、竹原めぐみ、尾本和、水沼洋文
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京(台場)
  • Year and Date: 2009-07-14
• [Presentation] Sentinel lymph node identification method using contrast- enhanced ultrasonography with Sonazoid_TM in breast cancer (2009)
  • Author(s): Kiyoka Omoto, Natsuki Take, Hiro-aki Matsunaga, Nobuyuki Taniguchi, Yasuo Hozumi, Megumi Takehara, Yawara Omoto, Mikihiko Kawano
  • Organizer: 12th World Congress of the World Federation for Ultrasound in Medicine and Biology
  • Place of Presentation: Sydney, Australia
• [Presentation] Sentinel lymph node identification method using contrast-enhanced ultrasonography with Sonazoid^<TM> in breast cancer (2009)
  • Author(s): 尾本きよか, 竹夏樹, 松永宏明, 谷口信行, 穂積康夫, 竹原めぐみ, 尾本和, 河野幹彦
  • Organizer: 12th World Congress of the World Federation for Ultrasound in Medicine and Biology
  • Place of Presentation: Sydney, Australia
• [Presentation] Novel method of sentinel node detection using contrast-enhanced ultrasonography with Sonazoid in breast cancer : Initial clinical experience (2008)
  • Author(s): Kiyoka Omoto, Hiroaki Matsunaga, Natsuki Take, Yasuo Hozumi, Megumi Takehara Yawara Omoto, Hirobumi Mizunuma, Nobuyuki Taniguchi, Mikihiko Kawano
  • Organizer: 第10回国際造影超音波シンポジウム
  • Place of Presentation: 東京医科大学病院(東京・新宿)
• [Presentation] ソナゾイドを用いた造影超音波法による乳癌センチネルリンパ節同定法の研究 (2008)
  • Author(s): 尾本きよか、河野幹彦、松永宏明、竹夏樹、谷口信行、穂積康夫、竹原めぐみ、尾本和、水沼洋文
  • Organizer: 第21回日本乳腺甲状腺超音波診断会議
  • Place of Presentation: 大阪国際会議場
• [Presentation] Novel method of sentinel node detection using contrast-enhanced ultrasonography with Sonazoid in breast cancer : Initial clinical experience (2008)
  • Author(s): 尾本きよかほか
  • Organizer: 第10回国際造影超音波シンポジウム
  • Place of Presentation: 東京・新宿東京医科大学病院
• [Presentation] ソナソイドを用いた造影超音波法による乳癌センチネルリンパ節同定法の研究 (2008)
  • Author(s): 尾本きよかほか
  • Organizer: 第21回日本乳腺甲状腺超音波診断会議
  • Place of Presentation: 大阪国際会議場