A novel cancer therapy using sonodynamics and antibody

• Project/Area Number: 19500430
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Fukuoka University
• Principal Investigator: KUROKI Motomu Fukuoka University, 医学部, 教授 (10131822)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 超音波医科学 / 音響化学療法 / 抗体療法 / 癌 / IgA / ADCC / 超音波感受性剤 / 超音波 / 癌細胞 / CEA / IgA抗体 / ヒト抗体 / 好中球 / FcRI

Research Abstract

癌の治療を目的として、癌抗原CEAに対するヒトIgA抗体の組換え遺伝子を作製し、この遺伝子をカイコ幼虫に導入して抗癌IgA抗体をつくらせた。この抗体とヒト白血球を癌細胞に加えると癌細胞の細胞死が見られた。次に光感受性をもたない新しいポルフィリン誘導体DEG-Mn-DP-Hは超音波照射により強力な細胞傷害活性を示した。これらの結果から、超音波と音響化学物質とを用いた音響化学療法と、IgA抗体を使った抗体療法との併用が癌治療に有用である可能性が示唆された。

Research Products

• [Journal Article] Recombinant human monoclonal IgA antibody against CEA to recruit neutrophils to CEA-expressing cells (2008)
  • Author(s): Zhao J, Kuroki M, et al., 8名
  • Journal Title: Oncology Research 17 Pages: 217-222
  • Peer Reviewed
• [Journal Article] Recorabinant human monoclonal IgA antibody against CEA to recruit neutrophils to CEA -expressing cells. (2008)
  • Author(s): Jun Zhao
  • Journal Title: Oncology Research 17 Pages: 217-222
  • Peer Reviewed
• [Journal Article] ヒト抗CEA抗体の5-FUまたはCDDPとの併用による抗腫瘍効果 (2008)
  • Author(s): 芝口浩智
  • Journal Title: 日本分子腫瘍マーカー研究会誌 24 Pages: 83-84
• [Journal Article] Sonodynamic therapy of cancer using a novel porphyrin derivative, DCPH-P-Na(I), which is devoid of photosensitivity (2007)
  • Author(s): Hachimine K, Kuroki, M, et al., 11名
  • Journal Title: Cancer Science 98 Pages: 916-920
  • Peer Reviewed
• [Journal Article] Sonodynamic therapy of cancer using novel sonosensitizers (2007)
  • Author(s): Kuroki M, Kuroki M, et al., 他10名
  • Journal Title: Anticancer Research 27 Pages: 3673-3678
  • Peer Reviewed
• [Journal Article] Sonodynamic therapy of cancer using a novel porphyrin derivative, DCPH-P-Na(I), which is devoid of photosensitivity (2007)
  • Author(s): Ken Hachimine
  • Journal Title: Cancer Science 98 Pages: 916-920
  • Peer Reviewed
• [Journal Article] Sonodynamic therapy of cancer using novel sonosensitizers (2007)
  • Author(s): Masahide Kuroki
  • Journal Title: Anticancer Research 27 Pages: 3673-3678
  • Peer Reviewed
• [Journal Article] Recent Developments (2007)
  • Author(s): Toshiyuki Tanaka
  • Journal Title: Gene Therapy, 2007, Transworld Research Network,Kerala(India) Pages: 319-326
• [Presentation] Combination therapy of gastric cancer using a human antibody to CEA and anticancer drugs (2008)
  • Author(s): Shibaguchi H, Kuroki M, et al., 5名
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Combination therapy of gastric cancer using a human antibody to CEA and anticancer drugs. (2008)
  • Author(s): Hirotomo Hibaguchi
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Evaluation of Adv-FZ33 mediated genetransduction among anti-CEA Abs withdifferent subclasses of mouse and human IgGs (2007)
  • Author(s): Tanaka T, Kuroki M, et al., 他6名
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Evaluation of Adv-FZ33 mediated gene transduction amolng anti-CEAAbs with different subclasses of mouse and human lgGs: (2007)
  • Author(s): Toshiyuki Tanaka
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] Sonodynamic therapyof cancer using a novel porphyrin derivative, DCPH-P-Na(1), which is devoid of photosensitivity (2007)
  • Author(s): Kuroki M, Kuroki M, et al., 6名
  • Organizer: 35th Annual Meeting of the International Society for Oncodevelopmental Biology and Medicine
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2007-09-15
• [Presentation] Sonodynamic therapy of cancer using a novel porphyrin derivative, DCPH-P-Na(1),which is devoid of photosensitivity (2007)
  • Author(s): Masahide Kuroki
  • Organizer: 35th Annual Meeting of the International Society for Oncodevelopmental Biology and Medicine
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 2007-09-15
• [Presentation] Immune defense against cancer and application of antibodies in cancer therapy (2007)
  • Author(s): Kuroki M, Kuroki M, et al., 5名
  • Organizer: China National Teaching and Research Exchange Research Meeting on Medical Biology, 2007
  • Place of Presentation: Guilin, China
  • Year and Date: 2007-07-10
• [Book] Recent Developments in Gene Therapy (2007)
  • Author(s): Tanaka T, Kuroki M, et al., 7名
  • Publisher: Transworld Research Network, Kerala(India)
• [Book] Recent Developments in Gene Therapy, 2007 (2007)
  • Author(s): Toshiyuki Tanaka
  • Publisher: Transworld Research Network,Kerala(India)
• [Remarks]
  • URL: http://www.med.fukuoka-u.ac.jp/biocheml/index-j.htm
• [Remarks]
  • URL: http://www.med.fukuoka-u.ac.jp/biochem1/index-j.htm