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Exploration of the effective rehabilitative therapy and its mechanisms after stroke in rats

Research Project

Project/Area Number 19500442
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNagoya University

Principal Investigator

ISHIDA Kazuto  Nagoya University, 医学部(保健学科), 講師 (10303653)

Co-Investigator(Kenkyū-buntansha) TORIHASHI Shigeko  名古屋大学, 医学部(保健学科), 教授 (90112961)
Research Collaborator ISHIDA Akimasa  名古屋大学大学院, 医学系研究科(リハビリテーション療法学専攻), 大学院生
TAKAMATSU Yasuyuki  名古屋大学大学院, 医学系研究科(リハビリテーション療法学専攻), 大学院生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords脳出血モデル / 運動機能 / トレッドミル運動 / 運動強度 / 運動介入時期 / リハビリテーション / dark neuron / 運動療法
Research Abstract

脳卒中後のリハビリテーションには科学的根拠に基いた効果的な方法の開発が望まれる。本研究では、脳出血のモデル動物を作成し発症後早期からトレッドミル運動を行うと、運動機能の回復が促進され運動機能に関わる脳領域で神経細胞の樹状突起の枝が複雑化することを示した。また片側前肢の使用を制限し、反対側の麻痺した手を強制的に使用する治療法があり、この場合のストレス等による神経への障害性は一過性で少ないことを示した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (49 results)

All 2009 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (25 results) Book (5 results) Remarks (2 results)

  • [Journal Article] The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in mouse embryonic gut2009

    • Author(s)
      Torihashi S, Hattori T, Hasegawa H, Kurahashi M, Ogaeri T and Fujimoto T
    • Journal Title

      Differentiation 77

      Pages: 277-289

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 刺激入力の継続と脳機能再生に関する動物モデルによる研究2009

    • Author(s)
      石田和人
    • Journal Title

      理学療法の医学的基礎 12(印刷中)

    • NAID

      130007494842

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] マウスES 細胞を用いた骨格筋細胞の発生モデル2009

    • Author(s)
      鈴木麻友、水野陽太、蜷川菜々、八木保、鳥橋茂子
    • Journal Title

      理学療法の医学的基礎 12(印刷中)

    • NAID

      130007493827

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in mouse embryonic gut.2009

    • Author(s)
      Torihashi S, Hattori T, Hasegawa H, Kurahashi M, Ogaeri T, Fuiimoto T.
    • Journal Title

      Differentiation 77

      Pages: 277-289

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 刺激入力の継続と脳機能再生に関する動物モデルによる研究.2009

    • Author(s)
      石田和人
    • Journal Title

      理学療法の医学的基礎 12(印刷中)

    • NAID

      130007494842

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マウスES細胞を用いた骨格筋細胞の発生モデル2009

    • Author(s)
      鈴木麻友, 水野陽太, 蜷川菜々, 八木保, 鳥橋茂子
    • Journal Title

      療法の医学的基礎理学 12(印刷中)

    • NAID

      130007493827

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modafinil normalized hyperreflexia after spinal transection in adult rats2008

    • Author(s)
      Yates C, Charlesworth A, Reese N, Ishida K, Skinner RD and Garcia-Rill E
    • Journal Title

      Spinal Cord (On line)

      Pages: 1-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGF signals play crucial roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut2008

    • Author(s)
      Kurahashi M, Niwa Y, Cheng J, Ohsaki Y, Fujita A, Goto H, Fujimoto T and Torihashi S
    • Journal Title

      Neurogastroenterol Motil 20

      Pages: 521-531

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 理学療法への挑戦,そして広がる夢-神経系・基礎系-2008

    • Author(s)
      石田和人
    • Journal Title

      理学療法福井 12

      Pages: 11-15

    • Related Report
      2008 Final Research Report
  • [Journal Article] Modafihil normalized hyperreflexia after spinal transection in adult rats.2008

    • Author(s)
      Yates C, Charlesworth A, ReeseN, Ishida K, Skinner R, Garcia-Rill E.
    • Journal Title

      Spinal Cord On line

      Pages: 1-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGF signals play crucial roles in differentiation of longitud inal smooth muscle cells in mouse embryonic gut.2008

    • Author(s)
      Kurahashi M, Niwa Y, Cheng J, Ohsaki Y, Fujita A, Goto H, Fujimoto T, Torihashi S
    • Journal Title

      Neurogastroenterol Motil 20

      Pages: 521-531

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 理学療法への挑戦, そして広がる夢-神経系・基礎系-.2008

    • Author(s)
      石田和人
    • Journal Title

      理学療法福井 12

      Pages: 11-15

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PDGF signals play crucial roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut.2008

    • Author(s)
      Kurahashi M., et. al.
    • Journal Title

      Neurogastroenterol Motil In press

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phagocytotic Activation of Muscularis Resident Macro-phages Inhibits Smooth Muscle Contraction in Rat Ileum2007

    • Author(s)
      Sato K, Torihashi S, Hori M, Nasu T and Ozaki H
    • Journal Title

      J Vet Med Sci 69

      Pages: 1053-1060

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro developmental model of the gastrointestinal tract from mouse embryonic stem cells2007

    • Author(s)
      Torihashi S, Kuwahara M and Kurahashi M
    • Journal Title

      Nagoya Medical Journal 69

      Pages: 133-137

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phagocytotic Activation of Muscularis Resident Macro-phages Inhibits Smooth Muscle Contraction in Rat Ileum2007

    • Author(s)
      Sato K, et. al.
    • Journal Title

      J Vet Med Sci 69

      Pages: 1053-1060

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro developmental model of the gastrointestinal tract from mouse embryonic stem cells.2007

    • Author(s)
      Torihashi S, et. al.
    • Journal Title

      Nagoya Medical Journal 69

      Pages: 133-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of forced-disuse by constraint-induced movement therapy on the normal function : minor damages in the hippocampus with decreases of VEGF and GDNF2008

    • Author(s)
      A. Ishida, et.al.
    • Organizer
      Society for Neuroscience 38rd annual meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Passive exercise alters stretch reflex properties in rats with spinal cord transaction2008

    • Author(s)
      M. K. Garrison, et.al.
    • Organizer
      Society for Neuroscience 38rd annual meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2008-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of forced-disuse by constraint-induced movement therapy on the normal function : minor damages in the hippocampus with decreases of VEGF and GDNF.2008

    • Author(s)
      A. Ishida, et al.
    • Organizer
      Society for Neurosoience 38_<rd> annual meeting (Neuroscieiice 2008)
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Passive exercise alters stretch reflex properties in rats with spinal cord transaction.2008

    • Author(s)
      M. K. Garrison, et al.
    • Organizer
      Society for Neuroscience 38_<rd> annual meeting (Neuroscience 2008)
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットにおける前肢使用制限が運動機能および海馬の神経新生に及ぼす影響2008

    • Author(s)
      石田章真, 他
    • Organizer
      第55 回中部生理学会
    • Place of Presentation
      長久手
    • Year and Date
      2008-10-17
    • Related Report
      2008 Final Research Report
  • [Presentation] ラットにおける前肢使用制限が運動機能および海馬の神経新生に及ぼす影響.2008

    • Author(s)
      石田章真, 他
    • Organizer
      第55回中部生理学会
    • Place of Presentation
      長久手
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Environmental enrichment enhances the neurogenesis following brain lesions in rats2008

    • Author(s)
      S Urakawa, et.al.
    • Organizer
      10th International Congress of the Asian Confederation for Physical Therapy (ACPT)
    • Place of Presentation
      Makuhari, Chiba
    • Year and Date
      2008-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Environmental enrichment enhances the neurogenesis following brain lesions in rats.2008

    • Author(s)
      S Urakawa, et al.
    • Organizer
      10th International Congress of the Asian Confederation for Physical Therapy (ACPT)
    • Place of Presentation
      Makuhari, Chiba
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Restraint effect of unilateral forelimb on histological changes and neurogenesis in central nervous system in rats2008

    • Author(s)
      石田章真, 他
    • Organizer
      第31 回日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Restraint effect of unilateral forelimb on histological changes and neurogenesis in central nervous system in rats.2008

    • Author(s)
      石田章真, 他
    • Organizer
      第31回日本神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 刺激入力の継続と脳機能再生に関する動物モデルによる研究2008

    • Author(s)
      石田和人
    • Organizer
      第13 回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 一側前肢の使用制限が中枢神経組織および神経新生に及ぼす影響2008

    • Author(s)
      石田章真, 他
    • Organizer
      第13 回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳出血モデルにおける急性期の脳組織学的変化 ~dark neuron に着目して~2008

    • Author(s)
      高松泰行, 他
    • Organizer
      第13 回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 刺激入力の継続と脳機能再生に関する動物モデルによる研究.2008

    • Author(s)
      石田和人
    • Organizer
      第13回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一側前肢の使用制限が中枢神経組織および神経新生に及ぼす影響.2008

    • Author(s)
      石田章真, 他
    • Organizer
      第13回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳出血モデルにおける急性期の脳組織学的変化〜dark neuronに着目して〜.2008

    • Author(s)
      高松泰行, 他
    • Organizer
      第13回理学療法の医学的基礎研究会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳出血モデルラットに対する早期トレッドミル運動の効果-運動時期による効果の違い-2008

    • Author(s)
      渡邊裕介, 他
    • Organizer
      第43 回日本理学療法学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳出血モデルラットに対する早期トレッドミル運動の効果-運動時期による効果の違い-.2008

    • Author(s)
      渡邊裕介, 他
    • Organizer
      第43回日本理学療法学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脊髄損傷モデルラットにおける自転車式他動運動の後肢過反射抑制効果2008

    • Author(s)
      石田和人, 他
    • Organizer
      第43 回日本理学療法学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 脊髄損傷モデルラットにおける自転車式他動運動の後肢過反射抑制効果.2008

    • Author(s)
      石田和人, 他
    • Organizer
      第43回日本理学療法学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Changes in the H-reflex after spinal cord injury : a longitudinal study in awake rats2007

    • Author(s)
      Arfaj A. et.al.
    • Organizer
      Society for Neuroscience 37rd annual meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2007-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳出血モデルラットにおけるCI 療法の効果に関する検討2007

    • Author(s)
      石田章真, 他
    • Organizer
      第41 回日本理学療法学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2007-05-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 消化管平滑筋層の発生に関わるPDGFシグナル2007

    • Author(s)
      鳥橋 茂子
    • Organizer
      日本解剖学会第112回全国学術集会 シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Changes in the H-reflex after spinal cord injury: a longitudinal study in awake rats.2007

    • Author(s)
      Arfaj A., et. al.
    • Organizer
      Society for Neuroscience 37rd annual meeting(Neuroscience 2007)
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳出血モデルラットにおけるCI療法の効果に関する検討2007

    • Author(s)
      石田 章真・ほか
    • Organizer
      第41回日本理学療法学術大会
    • Place of Presentation
      新潟
    • Related Report
      2007 Annual Research Report
  • [Book] 理学療法MOOK第16巻脳科学と理学療法2008

    • Author(s)
      石田和人
    • Total Pages
      243
    • Publisher
      三輪書店
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Book] 人体解剖カラーリングブック2008

    • Author(s)
      天野修、千田隆夫、鳥橋茂子(監訳)
    • Total Pages
      219
    • Publisher
      丸善株式会社
    • Related Report
      2008 Final Research Report
  • [Book] 人体解剖カラーリングブック2008

    • Author(s)
      天野修, 千田隆夫, 鳥橋茂子監訳
    • Total Pages
      219
    • Publisher
      丸善株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] 障害別・ケースで学ぶ理学療法臨床思考 PBL で考え進める2007

    • Author(s)
      石田和人
    • Total Pages
      496
    • Publisher
      文光堂
    • Related Report
      2008 Final Research Report
  • [Book] 障害別・ケースで学ぶ理学療法臨床思考PBLで考え進める

    • Author(s)
      石田 和人
    • Publisher
      文光堂
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/ishida/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/ishida/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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