The study of optimal stimulation for artificial vision with temporal consideration

• Project/Area Number: 19500445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Osaka University
• Principal Investigator: MIYOSHI Tomomitsu Osaka University, 医学系研究科, 助教 (70314309)
• Co-Investigator(Kenkyū-buntansha): SAWAI Hajime 大阪大学, 医学系研究科, 准教授 (20202103)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生理学 / 神経科学 / リハビリテーション / 人工感覚器 / 医工学 / 人工視覚 / 電気刺激 / 網膜 / 大脳皮質 / 人工網膜 / 外側膝状体 / スパイク活動

Research Abstract

To reveal the spatiotemporal property of suprachoroidal-transretinal stimulation as retinal prosthesis, cortical response was analyzed electrophysiologically. Two-dimensional mapping revealed the distribution of electrical evoked responses corresponding to the positions of stimulating electrodes. The amplitude of negative peak of anodic-first STS was larger than cathodic-first one, though the difference was only small.

Research Products

• [Journal Article] Optimal parameters of transcorneal electrical stimulation (TES) to be Neuroprotective of axotomized RGCs in adult rats. (2010)
  • Author(s): 澤井元, 三好智満, 不二門尚, 田野保雄.
  • Journal Title: Exp Eye Res 90 Pages: 285-291
  • Peer Reviewed
• [Journal Article] Optimal parameters of transcorneal electrical stimulation (TES) to be Neuroprotective of axotomized RGCs in adult rats (2010)
  • Author(s): Morimoto T, Miyoshi T, Sawai H, Fujikado T
  • Journal Title: Exp Eye Res 90 Pages: 285-291
  • Peer Reviewed
• [Journal Article] Axonal regeneration induced by repetitive electrical stimulation of crushed opticnerve in adult rats (2009)
  • Author(s): Tagami Y, Kurimoto T, Miyoshi T, Morimoto T, Sawai H, Mimura O
  • Journal Title: Jpn J Ophthalmol 53 Pages: 257-266
  • NAID: 10025150141
  • Peer Reviewed
• [Journal Article] 人工視覚. (2008)
  • Author(s): 澤井元, 三好智満, 不二門尚, 田野保雄.
  • Journal Title: 人工臓器 37 Pages: 163-167
  • NAID: 10025704592
• [Journal Article] 人工視覚 (2008)
  • Author(s): 澤井元, 三好智満, 不二門尚田野保雄
  • Journal Title: 人工臓器 3 7 Pages: 163-167
  • NAID: 10025704592
• [Journal Article] Cilostazol promotes survival of axotomized retinal ganglion cells in adult rats. (2008)
  • Author(s): Kashimoto, Kurimoto, Miyoshi, Okamoto, Tagami, Oono, Ito, Mimura
  • Journal Title: Neuroscience Letters (印刷中)
  • Peer Reviewed
• [Journal Article] Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college surgeons rats. (2007)
  • Author(s): Morimoto T., Fujikado T., Choi J-S., Kanda H., 三好智満, Fukuda Y., 田野保雄.
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 4725-4732
  • Peer Reviewed
• [Journal Article] Optical imaging to evaluate retinal activation by electrical current usingby electrical current using suptachoroidal-transretinal stimulation. (2007)
  • Author(s): Okawa Y., Fujikado T., 三好智満, 澤井元, Kusaka T., Mihashi T., Hirohara Y., 田野保雄.
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 4777-4784
  • Peer Reviewed
• [Journal Article] Optical imaging to evaluate retinal activation by electrical current using suptachoroidal-transretinal stimulation. (2007)
  • Author(s): Okawa, Fujikado, Miyoshi, Sawai, Kusaka, Mihashi, Hirohara, Tano
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 4777-4784
  • Peer Reviewed
• [Journal Article] Transcorneal electrical stimulation promotes the survival of photoreceptors and preserves retinal function in royal college surgeons rats. (2007)
  • Author(s): Morimoto, Fujikado Choi, Kanda Miyoshi, Fukuda, Tano
  • Journal Title: Invest Ophthalmol Vis Sci 48 Pages: 4725-4732
  • Peer Reviewed
• [Presentation] Optimal parameters of transcorneal electrical stimulation for neuroprotection of axotomized retinal ganglion cells in adult rats. (2009)
  • Author(s): Miyoshi T, et al.
  • Organizer: 36th International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan.
  • Year and Date: 2009-07-30
• [Presentation] Optimal parameters of transcorneal electrical stimulation for neuroprotection of axotomized retinal ganglion cells in adult rats (2009)
  • Author(s): Miyoshi T, Morimoto T, Sawai H, Fujikado T, Tano Y
  • Organizer: 36th International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Cortical evaluation of Suprachoroidal Transretinal Stimulation for retinal prosthesis in cat. (2008)
  • Author(s): Miyoshi, T.
  • Organizer: 4th Asia-Pacific Conference on Vision
  • Place of Presentation: Brisbane, Australia.
  • Year and Date: 2008-07-18
• [Presentation] Cortical evaluation of Suprachoroidal Transretinal Stimulation for retinal prosthesis in cat. (2008)
  • Author(s): Miyoshi, T
  • Organizer: 4^<th> Asia-Pacific Conference on Vision
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2008-07-18
• [Presentation] 脈絡膜上-経網膜刺激による網膜内因性信号の変化 (2007)
  • Author(s): Miyoshi, et. al.
  • Organizer: 視覚科学フォーラム第11回研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2007-10-04