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Function of thermosensitive receptor in neurogenic bladder

Research Project

Project/Area Number 19500449
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKagoshima University

Principal Investigator

YOSHIDA Akira  Kagoshima University, 大学院・医歯学総合研究科, 助教 (40347109)

Co-Investigator(Kenkyū-buntansha) IKEDA Satoshi  鹿児島大学, 大学院・医歯学総合研究科, 講師 (00343369)
OOWATASHI Akihiko  鹿児島大学, 医学部, 助教 (30295282)
KAWAHIRA Kazumi  鹿児島大学, 大学院・医歯学総合研究科, 教授 (20117493)
KAMIKAWA Yurie  鹿児島大学, 医学部・歯学部附属病院, 医員 (70418854)
SHIMOZONO Yurika  鹿児島大学, 医学部・歯学部附属病院, 医員 (80418855)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords温度受容体 / ラット / 脊髄損傷 / メントール / 温熱 / 神経因性膀胱 / シストメトリー / 排尿反射
Research Abstract

脊髄損傷ラットと正常ラットを用い、寒冷受容体TRPM8の作動薬のメントール、熱受容体TRPV1の作動薬のカプサイシンと類似構造を持つラズベリーケトンと42℃の温熱が排尿機能へ与える影響を調ベ、メントールが膀胱平滑筋の弛緩作用を持ち、メントールの膀胱内注入が脊髄損傷ラットの膀胱容量を増加させること、ラズベリーケトンと42℃の温熱が膀胱平滑筋の弛緩作用を持つことを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Effect of menthol on detrusor smooth Muscle contraction and the micturition reflex in rats2008

    • Author(s)
      Nomoto Y, Yoshida A, Ikeda S, Kamikawa Y, Harada K, Ohwatashi A, Kawahira K
    • Journal Title

      Urology 72

      Pages: 701-705

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of menthol 0n detrusor smooth-muscle contraction and the micturition reflex in rats2008

    • Author(s)
      Nomoto Y, Yoshida A, Ikeda S, et al.
    • Journal Title

      Urology 72

      Pages: 701-705

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats.2008

    • Author(s)
      Nomoto Y, Yoshida A, Ikeda S, et. al.
    • Journal Title

      Urology 71(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional recovery and expression of GDNF seen in photochemically induced cerebral infraction2007

    • Author(s)
      Horinouchi K, Ikeda S, Harada K, Ohwatashi A, Kamikawa Y, Yoshida A, Nomoto Y, Kawahira K
    • Journal Title

      International Journal of Neuroscience 117

      Pages: 315-326

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] ラット排尿筋収縮に対するラズペリーケトンの作用2009

    • Author(s)
      下園由理香, 吉田 輝, 他
    • Organizer
      第15回日本排尿機能学会
    • Place of Presentation
      大手町サンケイプラザ(東京都)
    • Year and Date
      2009-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット排尿筋収縮に対するラズベリーケトンの作用2008

    • Author(s)
      下園由理香、吉田輝、池田聡、上川百合恵、原田雄大、根路銘周子、大渡昭彦、川平和美
    • Organizer
      第15回日本排尿機能学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-09-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of menthol on micturition in rats with spinal cord injury2007

    • Author(s)
      Yoshida A, Nomoto Y, Ikeda S, et. al.
    • Organizer
      4th world congress of international society of physical and rehabilitation medicine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-06-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of menthol on micturition in rats with spinal cord injury2007

    • Author(s)
      Yoshida A, Nomoto Y, Ikeda S, Kamikawa Y, Harada K, Ohwatashi A, Kawahira K
    • Organizer
      4th World Congress of the International Society of Physical and Rehabilitation
    • Place of Presentation
      Seoul
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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