| Project/Area Number |
19500457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
GOTO Yoshinobu International University of Health and Welfare, 保健医療学部, 准教授 (30336028)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Hironobu 大阪保健医療大学, 保健医療学部, 教授 (50320487)
YAMASAKI Takao 九州大学, 大学院・医学研究院, 特任助教 (70404069)
SUGI Takenao 佐賀大学, 海洋エネルギー研究センター, 准教授 (00274580)
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| Research Collaborator |
YOSHIDA Takeshi 柳川リハビリテーション病院, 作業療法士
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 視空間認知障害 / 運動視 / 脳神経機能障害 / 事象関連電位 / 探索眼球運動 / 放射状運動(optic flow) / 軽度認知障害 / リハビリテーション / 視覚情報処理 |
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| Research Abstract |
It is well known that the higher-level dorsal stream integrates local motion signals from V1 into global motion. Thus, coherent motion stimuli will be able to use for evaluating the global motion defects. In addition, there are several types of global motion including radial optic flow (OF) and horizontal motion (HO). In this study, ERPs elicited by coherent OF and HO stimuli were recorded and analyzed in healthy young and old adults, and mild cognitive impairment patients. In the results, two major components (N170 and P200) were obtained in healthy young adults. N170 with V5/MT origin was evoked by both stimuli. In contrast, P200 with an IPL (BA 40) origin was elicited only by OF. These findings suggested that N170 was a nonspecific motion-related component originating from V5/MT, while P200 was an OF-specific component generated by the IPL. Therefore, a combined approach of ERPs using coherent motion (particularly OF) can be useful for discriminating MCI and AD patients from healthy old adults.
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