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Histological analysis of the osteochondritis dissecans

Research Project

Project/Area Number 19500558
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionHirosaki University

Principal Investigator

KUSUMI Tomomi  Hirosaki University, 大学院・医学研究科, 講師 (90322932)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Yasuyuki  弘前大学, 大学院・医学研究科, 准教授 (80292142)
KUSUMI Akinori  弘前大学, 大学院・医学研究科, 客員研究員 (90332494)
KIJIMA Hiroshi  弘前大学, 大学院・医学研究科, 教授 (90204859)
津田 英一  弘前大学, 医学部附属病院, 講師 (00361014)
佐藤 冬樹  弘前大学, 大学院・医学研究科, 助教 (60400131)
Co-Investigator(Renkei-kenkyūsha) TSUDA Eiichi  弘前大学, 医学部附属病院, 講師 (00361014)
SATO Fuyuki  弘前大学, 大学院・医学研究科, 助教 (60400131)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords関節疾患 / スポーツ医学 / 組織学 / 離断性骨軟骨炎
Research Abstract

離断性骨軟骨炎の罹患関節による病因・病態の相違を組織学的に検討した。手術を受けた肘・膝・足関節の病変部から採取された骨軟骨円柱標本を用いた。肘での分離は早期では関節軟骨深層で進行すると軟骨下骨が優位であった。軟骨・骨両方への微小外傷が主因と考えられた。膝は同様に微小外傷による変化と考えられるが、虚血性骨壊死像を呈する症例が少数あり、単一ではなく複合した病因と考えられた。足関節では軟骨損傷の関与は少なく、骨軟骨骨折の遷延が病因と考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 8 results)

  • [Journal Article] Passage-affected competitive regulation of osteoprotegerin synthesis and the receptor activator of nuclear factor-κB ligand mRNA expression in normal human osteoblasts stimulated by the application of cyclic tensile strain2009

    • Author(s)
      Kusumi T, Kusumi A, Miura A, Tateishi T.
    • Journal Title

      J Bone Miner Metab (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 関節遊離体の臨床病理 : 離断性骨軟骨炎を中心に2009

    • Author(s)
      楠美智巳, 津田英一, 石橋恭之, 楠美昭則, 鬼島宏
    • Journal Title

      病理と臨床 27(3)

      Pages: 275-282

    • Related Report
      2008 Final Research Report
  • [Journal Article] 関節遊離体の臨床病理 : 離断性骨軟骨炎を中心に2009

    • Author(s)
      楠美智巳
    • Journal Title

      病理と臨床 27

      Pages: 275-282

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Passage-ffected competitive regulation of osteoprotegerin synthesis and the receptor activator of nuclear factor-κB ligand mRNA expression in normal human osteoblasts stimulated by the application of cyclic tensile strain2009

    • Author(s)
      Akinori Kusumi
    • Journal Title

      I Bone Miner Metab 27(in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection of the carcinoma in the specimen obtained radial prostatectomy following hormone therapy2008

    • Author(s)
      Kusumi T, Koie T, Tanaka T, Matsumoto K, Sato F, Kusumi A, Ohyama C, Kijima H.
    • Journal Title

      Pathol Int 58(11)

      Pages: 687-694

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification2008

    • Author(s)
      Nishi T, Kusumi T, Tanaka M, Sato F, Sasaki M, Kudo H, Kijima H.
    • Journal Title

      Anticancer Res 28(3A)

      Pages: 1627-1631

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of transplantable murine osteosarcoma cell line with endochondral ossification2008

    • Author(s)
      Takashi Nishi
    • Journal Title

      Anticancer Research 28

      Pages: 1627-1631

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locally administrated low-dose alendronate increases bone mineral density but bone strength during distraction osteogenesis in a rabbit model2007

    • Author(s)
      Omi H, Kusumi T, Kijima H, Toh S.
    • Journal Title

      J Bone Joint Surg Br 89(7)

      Pages: 984-948

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of immunohistochemical analysis for cyclooxygenase-2(COX-2)in the differential diagnosis of osteoblastoma and osteosarcoma2007

    • Author(s)
      Hosono A, Yamaguchi U, Makimoto A, Endo M, Watanabe A, Shimoda T, Kaya M, Mitsunori T, Sonobe H, Kusumi T, Yamaguchi T, Hasegawa T.
    • Journal Title

      J Clin Pathol 60(4)

      Pages: 410-414

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical demonstration of growth factors at the tendon-bone interface in anterior cruciate ligament reconstruction using a rabbit model2007

    • Author(s)
      Kohno T, Ishibashi Y, Tsuda E, Kusumi T, Tanaka M, Toh S.
    • Journal Title

      J Orthop Sci 12(1)

      Pages: 67-73

    • NAID

      10018487616

    • Related Report
      2008 Final Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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