| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
The glycogen content in skeletal muscle of L-Ex (low carbohydrate diet exercise) rats was decreased compared with that of N-Ex (normal chow diet exercise) rats. Taken together, we suggest that the maintenance of glycogen depletion after exercise by continuous low carbohydrate diet results in the increment of the GLUT-4 protein content in skeletal muscle. Moreover, the combination of CR (calorie restriction) and exercise enhanced insulin action in the skeletal muscle of normal animals. Exercise suppressed the fat accumulation and induced Glut-4 protein expression in skeletal muscle, while short-term CR neither suppressed fat accumulation nor induced any changes in insulin signal transduction.
|
