Effects of physical training and diet restriction on life-span and insulin resistance in rats
Project/Area Number |
19500562
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Sports science
|
Research Institution | Nagoya University |
Principal Investigator |
OSHIDA Yoshiharu Nagoya University, 総合保健体育科学センター, 教授 (10169295)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 食事療法 / 運動療法 / インスリン感受性 / インスリン抵抗性 / 食事制限 / 食餌療法 / インスリン作用 / GLUT4 / 骨格筋 / グリコーゲン / 水泳トレーニング / 低糖質食 |
Research Abstract |
The glycogen content in skeletal muscle of L-Ex (low carbohydrate diet exercise) rats was decreased compared with that of N-Ex (normal chow diet exercise) rats. Taken together, we suggest that the maintenance of glycogen depletion after exercise by continuous low carbohydrate diet results in the increment of the GLUT-4 protein content in skeletal muscle. Moreover, the combination of CR (calorie restriction) and exercise enhanced insulin action in the skeletal muscle of normal animals. Exercise suppressed the fat accumulation and induced Glut-4 protein expression in skeletal muscle, while short-term CR neither suppressed fat accumulation nor induced any changes in insulin signal transduction.
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Report
(4 results)
Research Products
(45 results)