Basic studies on high-altitude training : Changes in the sensitivity on airway mucosa in chronic hypoxia

• Project/Area Number: 19500569
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Kokushikan University
• Principal Investigator: KUSAKABE Tatsumi Kokushikan University, 体育学部, 教授 (80117663)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Hideki 横浜市立大学, 医学部, 准教授 (80305458)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 高地トレーニング / 低酸素 / 高血圧 / 化学受容器 / 気道粘膜 / 神経ペプチド / カルシウム結合タンパク / 免疫組織化学 / 呼吸器 / 化学受容 / 神経支配 / ラット

Research Abstract

低酸素環境下の気道粘膜におけるペプチド性神経線維の増加は、気道系防御機構に関わる知覚機構の亢進を示唆する。さらに、化学受容細胞における水受容は同神経支配のコントロール下にあるものと推測される。これらの変化は、細胞内カルシウムを介した化学受容機序の変化によるものである可能性が示された。一方、舌・化学受容機におけるカルシウム結合タンパク含有線維の密度の変化は、体内電解質の恒常性維持のための適応であろうと考えられた。

Research Products

• [Journal Article] Treatment results and prognostic factors for advanced squamous cell cartinoma of the head and neck trated with concurrent chemoradiotherapy. (2009)
  • Author(s): T. Taguchi, et., al.
  • Journal Title: Auris Nasus Larynx (in press)
  • Peer Reviewed
• [Journal Article] Early assessment of clinical response to concurrent chemoradiotherapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission topography. (2008)
  • Author(s): C. Horiguchi, T. Taguchi, T. Yoshida, G. Nishimura, M. Kawakami, Y. Taniguchi, H. Matsuda, Y. Mikami, M. Tsukuda
  • Journal Title: Auris Nasus Larynx 35 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Antitumor effect of gefitinib on head and neck squamous cellcarcinoma enhanced by trastuzumab (2008)
  • Author(s): N. Kondo, Y. Ishiguro, M. Kimura, K. Fujita, A. Sakakibara,T. Taguchi, G. Toth, H. Matsuda, M. Tsukuda
  • Journal Title: Oncol. Rep. 20 Pages: 373-378
  • Peer Reviewed
• [Journal Article] Treatment results and prognostic factors for advanced squamo us cell carcinoma of the head and neck treated with concurrent chemoradiotherapy (2008)
  • Author(s): T. Taguchi, M. Tsukuda, Y. Mikami, H. Matsuda, Y. Tanigaki, C. Horigucgi, G. Nishimura
  • Journal Title: Auris Nasus Larynx (in press)
  • Peer Reviewed
• [Journal Article] Early assessment of clinical response to concurrent chemothe-rapy in head and neck carcinoma using fluoro-2-deoxy-d-glucose positron emission topography. (2008)
  • Author(s): C. Horiguchi, et., al.
  • Journal Title: Auris Nasus Larynx 35 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Antitumor effect of gefitinib on head and neck squamous cell cartinoma enhanced by trastuzumab. (2008)
  • Author(s): N. Kondo, et., al.
  • Journal Title: Oncol. Rep. 20 Pages: 373-378
  • Peer Reviewed
• [Journal Article] Decrease of creatinine clearance rate with aging in patients with head and neck cancer in Japan (2007)
  • Author(s): Nishimura G., et. al.
  • Journal Title: Int. J. Clin. Oncol. 12 Pages: 120-124
  • Peer Reviewed
• [Journal Article] Antitumor effects of Nafamostat mesilate on head and neck squamous cell calcinoma (2007)
  • Author(s): Yamashita Y., et. al.
  • Journal Title: Auris Nasus Larynx 34 Pages: 487-491
  • Peer Reviewed
• [Journal Article] Antitumor effects of ZD6474 on head and neck squamous cell calcinoma (2007)
  • Author(s): Sano D., et. al.
  • Journal Title: Oncol Rep. 17 Pages: 289-295
  • Peer Reviewed
• [Presentation] 高血圧自然発症ラット(SHR)の舌味蕾におけるcalbindin D-28k免疫活性 (2009)
  • Author(s): 松田秀樹, 他
  • Organizer: 第114回日本解剖学会
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-29
• [Presentation] 高血圧自然発症ラット(SHR)の舌味蕾におけるcalbindinD-28k免疫活性 (2009)
  • Author(s): 松田秀樹、高橋優宏、佃守、川上倫、竹中敏文、日下部辰三
  • Organizer: 第114回日本解剖学会
  • Place of Presentation: 岡山
• [Presentation] ラットの舌および喉頭味蕾におけるcalbindin D-28k免疫活性:慢性低酸素暴露による変化 (2008)
  • Author(s): 松田 秀樹, 他
  • Organizer: 日本解剖学会
  • Place of Presentation: 大分大学医学部
  • Year and Date: 2008-03-28
• [Presentation] 高血圧自然発症ラット(SHR)頚動脈小体の形態学的特徴 (2007)
  • Author(s): 松田秀樹、林田嘉朗、川上倫、竹中敏文、日下部辰三
  • Organizer: 第112回日本解剖学会
  • Place of Presentation: 大阪
• [Presentation] 慢性低酸素暴露ラットの舌および喉頭味蕾におけるcalbindin D-28k 免疫活性 (2007)
  • Author(s): 日下部辰三、平川晴久、及川秀、川上倫、竹中敏文、林田嘉朗
  • Organizer: 第84回日本生理学会
  • Place of Presentation: 大阪
• [Presentation] ラットの舌および喉頭味蕾におけるcalbindin D-28k 免疫活性 : 慢性低酸素暴露による変化 (2007)
  • Author(s): 松田秀樹、林田嘉朗、川上倫、竹中敏文、日下部辰三
  • Organizer: 第113回日本解剖学会
  • Place of Presentation: 大分
• [Book] The amphibian carotid labyrinth. In : Structure, evolution and function of airway chemoreceptors in the vertebrate(in press)(G Zaccone,E. Cutz, D. Adriaenson, C. Nurse, A. Mauceri (eds).) (2009)
  • Author(s): T. Kusakabe
  • Publisher: Plymouth UK
• [Book] Structure, evolution and function of airway chemoreceptors in the vertebrates. (2009)
  • Author(s): T. Kusakabe
  • Publisher: The amphibian carotid labyrinth. (in press)
• [Book] Airway chemoreceptore(分担執筆) (2008)
  • Author(s): G. Zaccone