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A Study on Coagulation and Fibrinolytic Characteristics and Effective Interventions for Childhood Metabolic Syndrome

Research Project

Project/Area Number 19500591
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

HORIGOME Hitoshi  University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (50241823)

Co-Investigator(Kenkyū-buntansha) HANAKI Keiichi  鳥取大学, 医学部, 教授 (20238041)
KAMODA Tomohiro  筑波大学, 大学院・人間総合科学研究科, 准教授 (50224704)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords生活習慣病 / 凝固線溶系 / メタボリックシンドローム / 小児 / アディポサイトカイン / 循環器・高血圧 / 血液凝固線溶系 / 小児科
Research Abstract

生活習慣病やメタボリックシンドロームの起源は胎児期から小児期にあると考えられているが、小児期における血液学的指標の標準値は確立されていない。健康な小学4年生の計148名(男児71:女児77名)を対象とし、腹囲を含む身体計測、血圧測定と朝空腹時採血による凝固線溶系指標、アディポカインを含む血液検査を行った。腹部脂肪の蓄積と凝固促進・線溶低下を示す血液学的指標およびレプチンとの相関がみられた。これらが小児期からの病態進展に関与し、診断の鋭敏な指標となる可能性があると考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Coronary artery dilatation in LEOPARD syndrome2009

    • Author(s)
      Iwasaki Y, Horigome H, Takahashi M, Kato Y, Razzaque MA, Matsuoka R
    • Journal Title

      A child case and literature review. Congenital Heart Disease 2009 4

      Pages: 38-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apical hypertrophic cardiomyopathy in childhood : A long-term follow-up report of two cases2009

    • Author(s)
      Miyamoto T, Horigome H, Kawano S, Sumazaki R
    • Journal Title

      Pediatric Cardiology 2009 30

      Pages: 343-346

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      加藤愛章、堀米仁志、高橋実穂、平松祐司、仁科秀崇、舩山康則
    • Journal Title

      日本小児循環器学会雑誌 25

      Pages: 56-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determinants of blood rheology in healthy adults and children using the microchannel array flow analyzer2009

    • Author(s)
      Katayama Y, Horigome H, Takahashi H, Tanaka K, Yoshinaga M.
    • Journal Title

      Clin Appl Thromb Hemost 2009 (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coronary artery dilatation in LEOPARD syndrome. A child case and literature review2009

    • Author(s)
      Iwasaki Y, Horigome H, Takahashi M, Kato Y, Razzaque MA, Matsuoka
    • Journal Title

      Congenital Heart Disease 4

      Pages: 38-41

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apical hypertrophic cardiomyopathy in childhood: A long-term follow-up report of two cases.2009

    • Author(s)
      Miyamoto T, Horigome H, Kawano S, Sumazaki R
    • Journal Title

      Pediatric Cardiology 30

      Pages: 343-346

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Journal of Cardiovascular Electrophysiology2008

    • Author(s)
      Horigome H, Iwashita H, Yoshinaga M, Shimizu W.
    • Journal Title

      19

      Pages: 334-335

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Review of scientific instruments 20082008

    • Author(s)
      Seki Y, Kandori A, Kumagai Y, Ohnuma M, Ishiyama A, Ishii T, Nakamura Y, Horigome H, Chiba T.
    • Journal Title

      79

      Pages: 36106-36106

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of diet with or without exercise on leptin and anticoagulation proteins levels in obesity2008

    • Author(s)
      Murakami T, Horigome H, Tanaka K, Nakata Y, Katayama Y, Matsui A.
    • Journal Title

      Blood Coagul Fibrinolysis 18

      Pages: 389-394

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetocardiographic demonstration of torsade de pointes in a fetus with congenital long QT syndrome.2008

    • Author(s)
      Horigome H, Iwashita H,Yoshinaga M, Shimizu W
    • Journal Title

      Journal of Cardiovascular Electrophysiology 19

      Pages: 334-335

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unshielded fetal magnetocardiography system using two-dimensional gradiometers2008

    • Author(s)
      Seki Y, Kandori A, Kumagai Y, Ohnuma M, Ishiyama A, Ishii T, Nakamura Y, Horigome H, Chiba T.
    • Journal Title

      The Review of scientific instruments 79

      Pages: 36106-36106

    • NAID

      120007138844

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetocardiographic demonstration of torsade de pointes in a fetuswith congenital long QT syndrome2008

    • Author(s)
      Horigome H, et. al.
    • Journal Title

      J Cardiovasc Electrophysiol 19

      Pages: 334-335

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of diet with or without exercise on leptin and anti-coagulation proteins levels in obesity2007

    • Author(s)
      Murakami T, Horigome H, et. al.
    • Journal Title

      Blood Coagul Fibrinolysis 18

      Pages: 389-394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-phenotype correlations of KCNJ2 mutations in Japanese patients with Andersen-Tawil syndrome2007

    • Author(s)
      Haruna Y, 他20名、Horigome H(17番目)
    • Journal Title

      Hum Mutat 28

      Pages: 208-208

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 幼児におけるメタボリックシンドローム関連指標と血液凝固線溶系2008

    • Author(s)
      堀米仁志、片山靖富、宮本朋幸、花木啓一、吉永正夫
    • Organizer
      第111回小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 幼児における生活習慣病関連指標の基準値2008

    • Author(s)
      堀米仁志、片山靖富、宮本朋幸、花木啓一、吉永正夫
    • Organizer
      第111回小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 幼児におけるメタボリックシンドローム関連指標と血液凝固系2007

    • Author(s)
      堀米仁志、片山靖富、宮本朋幸、吉永正夫
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      浦安
    • Year and Date
      2007-09-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 幼児におけるメタボリックシンドローム関連指標と血液凝固線溶系2007

    • Author(s)
      堀米仁志、片山靖富、他2名
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      浦安
    • Year and Date
      2007-09-10
    • Related Report
      2007 Annual Research Report
  • [Book] メタボリックシンドロームと血栓(五十嵐隆編)2009

    • Author(s)
      堀米仁志
    • Publisher
      小児科ピクシス(小児メタボリックシンドローム)(中山書店、東京)
    • Related Report
      2008 Final Research Report
  • [Book] 周生期循環異常2007

    • Author(s)
      堀米 仁志
    • Total Pages
      222
    • Publisher
      メディカル・ビュー社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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