A new health guidance and selection method for high risk group of lifestyle-related disease by means of visceral fat and exogenous lipoproteins

• Project/Area Number: 19500597
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Osaka University
• Principal Investigator: NISHIDA Makoto Osaka University, 保健センター, 准教授 (00379273)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Shizuya 大阪大学, 大学院・医学系研究科, 準教授 (60243242)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 内科 / 脂質 / 内臓脂肪 / 動脈硬化 / 健康診断 / メタボリックシンドローム / サイトカイン / 外因性リポ蛋白 / 外因性リボ蛋白

Research Abstract

健診受診者で、腹囲は内臓脂肪面積と同程度に動脈硬化危険因子と相関した。そして腹部肥満が、頸動脈硬化(IMT) のリスクであることを示した。さらに経年的に増悪するIMTには、腹囲の変化が、他のリスク変化より重要であることを示し、保健指導の指標としての腹囲測定の有用性を示した。また外因性リポ蛋白マーカーであるアポB48はIMTとの相関はなかったが、内臓脂肪面積や生活習慣によく相関しており、さらなる検討に値する。

Research Products

• [Journal Article] Abdominal obesity exhibits distinct effect on inflammatory network in apparently healthy Japanese men (2007)
  • Author(s): Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K.
  • Journal Title: Cardiovasc Diabetol 6(1) Pages: 27-27
  • Peer Reviewed
• [Journal Article] Interleukin-10 associates with adiponectin predominantly in subjects with metabolic syndrome (2007)
  • Author(s): Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K
  • Journal Title: Circ J. 71(8) Pages: 1234-1238
  • NAID: 110006368848
  • Peer Reviewed
• [Journal Article] Effects of IL-6, adiponectin, CRP and metabolic syndrome onsubclinical atherosclerosis (2007)
  • Author(s): Nishida M, Moriyama T, Ishii K, Takashima S, Yoshizaki K, Sugita Y, Yamauchi-Takihara K
  • Journal Title: Clin Chim Acta 384(1-2) Pages: 99-104
  • Peer Reviewed
• [Journal Article] Abdominal obesity exhibits distinct effect on inflammatory network in apparently healthy Japanese men. (2007)
  • Author(s): Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K
  • Journal Title: Cardiovascular Diabetology 6 Pages: 27-27
  • Peer Reviewed
• [Presentation] Progress ion of Subclinical Atheroscleros is Associates with Visceral Fat Accumulat ion and Lifestyle (2009)
  • Author(s): Makoto Nishida, Y. Toyaia, S. Hikosoh, Y. Susita, T. Moriyama, K. Takihara.
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-29
• [Presentation] Progression of Subclinical Atherosclerosis Associates with VisceralFat Accumulation and Lifestyle (2009)
  • Author(s): Nishida M
  • Organizer: 第72回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-20
• [Presentation] Atherosclerosis Associates not with Increase of Risk Factors but with Change of Adiposity (2008)
  • Author(s): Nishida M
  • Organizer: 第71回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-30
• [Presentation] Abdominal Obesity with Inflammation Associates Progression of Metabolic Syndrome Components (2008)
  • Author(s): Nishida M
  • Organizer: 第71回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Presentation] CRP and Abdominal ObPredict Atherosclerosis -Gender Difference in Atherogenesis- (2008)
  • Author(s): Nishida M
  • Organizer: 第71回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-28