• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular epidemiological approach for the prevention of life-related diseases from the young generation

Research Project

Project/Area Number 19500600
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNagasaki University

Principal Investigator

TAKAMURA Noboru  Nagasaki University, 医歯薬学総合研究科, 教授 (30295068)

Co-Investigator(Kenkyū-buntansha) 中里 未央  長崎大学, 医歯薬学総合研究科, 助教 (00380973)
安部 恵代  長崎大学, 大学院・医歯薬学総合研究科, 助教 (90372771)
前田 隆浩  長崎大学, 大学院・医歯薬学総合研究科, 教授 (40284674)
草野 洋介  長崎ウエスレアン大学, 現代社会学部, 教授 (70325637)
青柳 潔  長崎大学, 大学院・医歯薬学総合研究科, 教授 (80295071)
Co-Investigator(Renkei-kenkyūsha) 草野 洋介  長崎ウエスレアン大学, 現代社会学部, 教授 (70325637)
安部 恵代  長崎大学, 医歯薬学総合研究科, 助教 (90372771)
前田 隆浩  長崎大学, 医歯薬学総合研究科, 教授 (40284674)
青柳 潔  長崎大学, 医歯薬学総合研究科, 教授 (80295071)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords若年者 / メタボリックシンドローム / メタボリック症候群 / レプチン / アディポネクチン / グレリン / ホモシステイン / 葉酸 / 動脈硬化
Research Abstract

メタボリック症候群の概念の普及とともに、生活習慣病予防の重要性がクローズアップされてきている。生活習慣病の進展による血管病変=動脈硬化は、心血管病変の原因として極めて重要であるが、その進行は幼少時、若年時からすでにはじまっていることが近年の研究から明らかにされてきており、若年世代からの動脈硬化の予防が今後ますます重要になってくると考えられる。その一方で、若年世代における食生活の乱れや運動不足に伴う肥満割合の増加が大きく取り上げられるなど、この世代における栄養状況の改善を通じた、生活習慣病の予防が重要課題となっている。そこで本申請では、日本人若年者を対象として動脈硬化関連因子について分子疫学的調査を行い、エビデンスに基づいた若年時からの栄養指導、保健指導による生活習慣病の予防を行った。対象者の身長、体重に加えて体組成計を用いて体脂肪率、筋肉量、推定骨量、さらに基礎代謝量、腹囲の測定を行い、空腹時採血を行い、赤血球、血漿、血清を分離し、レプチン・アディポネクチンといったアディポサイトカインやグレリン等の測定を行った。さらに超音波検査によって頸動脈内膜中膜複合体厚を、さらに血圧脈波装置によって心臓足首血管指数と血圧の測定を行い、一日度運動活動量についても加速度計を用いて評価を行った。その結果、血清中のレプチン・アディポネクチン比は他の関連因子と独立して頸動脈内膜中膜複合体厚と有意に相関することが明らかになり、またグレリンは運動活動量に関連することが明らかになった。以上より、これらの指標が今後の若年者における動脈硬化の指標として有用であることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2009 2008 2007 Other

All Journal Article (42 results) (of which Peer Reviewed: 42 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Incidence of chronic obstructive pulmonary disease in general clinics and relevant factors with FEV1/FVC2009

    • Author(s)
      Fukahori S, Matsuse H, Takamura N, Hirose H, Tsuchida T, Kawano T, Fukushima C, Mizuta Y, Kohno S
    • Journal Title

      Int J Clin Prac 63(2)

      Pages: 269-74

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease2008

    • Author(s)
      Akilzhanova A, Takamura N, Yamashita S
    • Journal Title

      JAMA 300(12)

      Pages: 1409-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between C677T/MTHFR Genotype and homocysteine concentration in Kazakh population2008

    • Author(s)
      Akilzhanova A, Takamura N, Kusano Y, Karazhanova L, Yamashita S, Saito H, Aoyagi K
    • Journal Title

      Asia Pac J Clin Nutr 17(2)

      Pages: 325-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis2008

    • Author(s)
      Kadota K, Takamura N, Aoyagi K, Yamasaki H, Usa T, Nakazato M, Maeda T, Wada M, Nakashima K, Abe K, Takeshima F, Ozono Y
    • Journal Title

      Circ J 72(2)

      Pages: 304-8

    • NAID

      110006571061

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease.2008

    • Author(s)
      Akilzhanova A, et al.
    • Journal Title

      JAMA 300

      Pages: 1409-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between C677T/MTHFR Genotype and homocysteine concentration in Kazakh population.2008

    • Author(s)
      Akilzhanova A, et al.
    • Journal Title

      Asia Pac J Clin Nutr 17

      Pages: 325-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Availability of cardio-ankle vascular index (CAVI)as a screening tool for atherosclerosis.2008

    • Author(s)
      Kadota K, et al.
    • Journal Title

      Circ J 72

      Pages: 304-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determinants of plasma homocysteine levels and carotid intima-media thickness in Japanese2007

    • Author(s)
      Takamura N, Abe Y, Nakazato M, Maeda T, Wada M, Nakashima K, Kusano Y, Aoyagi K
    • Journal Title

      Asia Pac J Clin Nutr 16(4)

      Pages: 698-703

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas2007

    • Author(s)
      Ishibashi K, Takamura N, Aoyagi K, Yamasaki H, Abiru N, Nakazato M, Kamihira S, Maeda T
    • Journal Title

      Clin Chem Lab Med 45(11)

      Pages: 1547-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Volunteering at Welfare Facilities in Japanese Senior Citizens on Their Own Well-being2007

    • Author(s)
      Shono I, Takamura N, Nakano M, Honda S
    • Journal Title

      Acta Med Nagasaki 52(2)

      Pages: 45-51

    • NAID

      110006271978

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of fat-free mass by whole-body counter in Japanese healthy young adults2007

    • Author(s)
      Morita N, Takamura N, Murakami T, Jo O, Aoyagi K, Yamashita S, Okumura Y
    • Journal Title

      Radiat Prot Dosim 123(1)

      Pages: 128-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ukraine Urinary Iodine Levels ; 20 years after the Chernobyl accident2007

    • Author(s)
      Takamura N, Bebeshko V, Aoyagi K, Yamashita S, Saito H
    • Journal Title

      Endocr J 54(2)

      Pages: 335-335

    • NAID

      10019478947

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RET Oncogene Amplification in Thyroid Cancer : Correlations with Radiation-associated and High-grade Malignancy2007

    • Author(s)
      Nakashima M, Takamura N, Namba H, Saenko V, Meirmanov S, Matsumoto N, Hayashi T, Maeda S, Sekine I
    • Journal Title

      Hum Pathol 38(4)

      Pages: 621-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of work duration or physical symptoms on mental health among Japanese visual display terminal users2007

    • Author(s)
      Ye Z, Honda S, Abe Y, Kusano Y, Takamura N, Imamura Y, Eida K, Takemoto T, Aoyagi K
    • Journal Title

      Ind Health 45(2)

      Pages: 328-33

    • NAID

      130004483228

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fear of Falling among Community-dwelling Elderly Women Receiving Visiting Nursing Services in Japan2007

    • Author(s)
      Takai K, Honda S, Ye Z, Abe Y, Takamura N, Osaki M, Kusano Y, Takemoto T, Aoyagi K
    • Journal Title

      Acta Med.Nagasaki 52

      Pages: 7-11

    • NAID

      110006184816

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of visual display terminal use on the physical and mental conditions of administrative staff in Japan2007

    • Author(s)
      Ye Z, Abe Y, Kusano Y, Takamura N, Eida K, Takemoto T, Aoyagi K
    • Journal Title

      J Physiol Anthropol 26(2)

      Pages: 69-73

    • NAID

      110006243392

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-perceived oral health status and influencing factors of the elderly residents of a peri-urban area of La Paz, Bolivia2007

    • Author(s)
      Ugarte J, Abe Y, Fukuda H, Honda S, Takamura N, Kobuke Y, Ye Z, Aoyagi K, Mendoza O, Shinsho F
    • Journal Title

      Int Dent J 57(1)

      Pages: 19-26

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The possibility of a valuable resource of circulating DNA for single nucleotide polymorphism genotyping : the application of a rapid and simple polymerase chain reaction with melting curve analysis for methylentetrahydrofolate reductase polymorphism2007

    • Author(s)
      Mori S, Sugahara K, Uemura A, Yamada Y, Uzihara K, Hayashida H, Ideguchi T, Ishibashi K, Nakazato M, Maeda T, Takamura N, Kamihira S
    • Journal Title

      Lab Hematol 13(1)

      Pages: 1-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults2007

    • Author(s)
      Yagura C, Takamura N, Kadota K, Nagazumi T, Morishita Y, Nakazato M, Maeda T, Kusano Y, Abe Y, Aoyagi K
    • Journal Title

      Clin Chem Lab Med 45(2)

      Pages: 220-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Availability of cardio-ankle vascular index(CAVI)as a screening tool for a therosclerosis.2007

    • Author(s)
      Kadota K
    • Journal Title

      Circulation Journal 72

      Pages: 304-308

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determinants of plasma homocysteine levels and carotid intima-media thickness in Japanese.2007

    • Author(s)
      Takamura N
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition 16

      Pages: 698-703

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas.2007

    • Author(s)
      Ishibashi K
    • Journal Title

      Clinical Chemistry and Laboratory Medicine 45

      Pages: 1547-1563

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of volunteering at welfare facilities in Japanese senior citizens on their own well-being.2007

    • Author(s)
      Shono I
    • Journal Title

      Acta Medica Nagasakiensia 52

      Pages: 45-51

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of fat-free mass by whole-body counter in Japanese healthy young adults.2007

    • Author(s)
      Morita N
    • Journal Title

      Radiation Protection and Docimetry 123

      Pages: 128-130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ukraine urinary iodine levels;20 years after the Chernobyl accident.2007

    • Author(s)
      Takamura N
    • Journal Title

      Endocrine Journal 54

      Pages: 335-335

    • NAID

      10019478947

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogene amplification in thyroid cancer:correlations with radiation-associated and high-grade malignancy.2007

    • Author(s)
      Nakashima M
    • Journal Title

      Human Pathology 38

      Pages: 621-628

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fear of falling among community-dwelling elderly women receiving visiting nursing services in Japan.2007

    • Author(s)
      Takai K
    • Journal Title

      Acta Medica Nagasakiensia 52

      Pages: 7-11

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of visual display terminal use on the physical and mental conditions of administrative staff in Japan.2007

    • Author(s)
      Ye Z
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition 16

      Pages: 698-703

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-perceived oral health status and influencing factors of the elderly residents of a peri-urban area of La Paz,Bolivia.2007

    • Author(s)
      Ugarte J
    • Journal Title

      International Dental Journal 57

      Pages: 19-26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The possibility of a valuable resource of circulating DNA for single nucleotide polymorphism genotyping:the application of a rapid and simple polymerase chain reaction with melting curve analysis for methylentetrahydrofolate reductase polymorphism.2007

    • Author(s)
      Mori S
    • Journal Title

      Laboratory Hematology 13

      Pages: 1-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults.2007

    • Author(s)
      Yagura C
    • Journal Title

      Intemational Dental Joumal 57

      Pages: 19-26

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depressive Status on Chinese Factory Workers in Nagasaki, Japan

    • Author(s)
      Date Y, Abe Y, Honda S, Ye Z, Takamura N, Tomita M, Osaki M, Aoyagi K.
    • Journal Title

      Ind Helath (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between periodontal status andHbA1c in non-diabetics.

    • Author(s)
      Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura N, Hara Y, Maeda T, Saito T
    • Journal Title

      J Public Health Dent (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary iodine concentrations in urban and rural areas around Chernobyl Nuclear Power Plant

    • Author(s)
      Taira Y, Hayashida N, Zhavaranak S, Kozlovsky A, Lyzikov A, Yamashita S, Takamura N
    • Journal Title

      Endocr J (in press)

    • NAID

      10026913066

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid function is associated with carotid intima media thickness in euthyroid subjects

    • Author(s)
      Takamura N, Akilzhanova A, Hayashida N, Kadota K, Yamasaki H, Usa T, Nakazato M, Maeda T, Ozono Y, Aoyagi K
    • Journal Title

      Atherosclerosis (in press)

    • NAID

      120006981790

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Status on Chinese Factory Workers in Nagasaki, Japan.

    • Author(s)
      Date Y, et al.
    • Journal Title

      Ind Helath (印刷中掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between periodontal status and HbA_<1c> in non-diabetics.

    • Author(s)
      Hayashida H, et al.
    • Journal Title

      J Public Health Dent (印刷中掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary iodine concentrations in urban and rural areas around Chernobyl Nuclear Power Plant.

    • Author(s)
      Taira Y, et al.
    • Journal Title

      Endocr J (印刷中掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid function is associated with carotid intima media thickness in euthyroid subjects.

    • Author(s)
      Takamura N
    • Journal Title

      Atherosclerosis (印刷中掲載確定)

    • NAID

      120006981790

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of chronic obstructive pulmonary disease in general clinics and relevant factors with FEV1/FVC.

    • Author(s)
      Fukahori S, et al.
    • Journal Title

      Int J Clin Prac (印刷中掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between C677T/MTHFR Genotype and homocysteine concentration in Kazakh population.

    • Author(s)
      Akilzhanova A
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of quality of life in Japanese normal pregnant women.

    • Author(s)
      Hama K
    • Journal Title

      Acta Medica Nagasakiensia (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 甲状腺機能正常者における甲状腺機能とCIMTとの関連2008

    • Author(s)
      高村昇
    • Organizer
      第51回日本甲状腺学会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 長崎県離島住民の血漿中ホモシステインに関する統計学的解析2008

    • Author(s)
      和田光弘
    • Organizer
      第48回日本臨床化学学会
    • Place of Presentation
      日浜松市
    • Year and Date
      2008-08-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 長崎県離島住民の血漿中ホモシステインに関する統計学的解析2008

    • Author(s)
      和田光弘
    • Organizer
      第48回日本臨床化学学会
    • Place of Presentation
      浜松市
    • Year and Date
      2008-08-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大学における放射線健康リスク管理のためのホールボディカウンタの応用2007

    • Author(s)
      森田直子
    • Organizer
      放射線安全管理学会第6回学術大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-12-05
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Determinants of homocysteine among the Kazakhs2007

    • Author(s)
      Takamura N
    • Organizer
      a population with low folate status 6th Conference on Homocysteine Metabolism
    • Place of Presentation
      Saarbrucken, (Germany)
    • Year and Date
      2007-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] An association between plasma homocysteine concentration and methylentetrahydrofplate reductase gene C677T polymorphism on a remote Japanese island2007

    • Author(s)
      Nakazato M
    • Organizer
      6th Conference on Homocysteine Metabolism
    • Place of Presentation
      Saarbrucken Saarbrucken(Germany)
    • Year and Date
      2007-06-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 血漿中ホモシステイン、システイン及びシステアミンのHPLC-蛍光定量とその解析2007

    • Author(s)
      中村真裕美
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-06-05
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Determinants of homocysteine among the Kazakhs,a population with low folate status2007

    • Author(s)
      Takamura N
    • Organizer
      6^<th> Conference on Homocysteine Metabolism
    • Place of Presentation
      Saarbrucken,Germany
    • Year and Date
      2007-06-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] An association between plasma homocysteine concentration and methylentetrahydrofplate reductase gene C677T polymorphism on a remote Japanese island.2007

    • Author(s)
      Nakazato M
    • Organizer
      6^<th> Conference on Homocysteine Metabolism
    • Place of Presentation
      Saarbrucken,Germany
    • Year and Date
      2007-06-05
    • Related Report
      2007 Annual Research Report
  • [Book] Research activities and projects within a framework of international radiation health sciences research2008

    • Author(s)
      Takamura N et.al.
    • Total Pages
      340
    • Publisher
      In Radiation Health Risk Sciences
    • Related Report
      2008 Final Research Report
  • [Book] Radiation health risk sciences2008

    • Author(s)
      Takamura N, et al.
    • Total Pages
      340
    • Publisher
      Research activities and projects within a framework of international radiation health sciences research.
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi