The study about the relationship between exercise therapy and oxidative stress in patients with COPD

• Project/Area Number: 19500615
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Tokyo Medical University
• Principal Investigator: OHISHI Shuji Tokyo Medical University, 医学部, 教授 (00322462)
• Co-Investigator(Kenkyū-buntansha): ITOH Masayuki 東京医科大学, 医学部, 助教 (10419731) ; MATSUZAKI Yasushi 東京医科大学, 医学部, 教授 (50209532)
• Research Collaborator: KENJI Nemoto 東京医科大学, 医学部, 大学院生
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 運動療法 / 抗酸化酵素 / 酸化ストレス / 慢性閉塞性肺疾患 / 過酸化脂質

Research Abstract

Comprehensive pulmonary rehabilitation (PR) program used in the current study significantly improved exercise performance in patients with chronic obstructive pulmonary disease (COPD). However, there was no significant change in any of respiratory function tests between pre- and post-rehabilitation. This PR also increased the concentrations or activities of some of major antioxidant enzymes in serum and red blood cells, probably leading to not adding to further exercise-induced oxidative stress. Moreover, this program improved not only quality of life (QOL) but also BODE index that is an indicator of prognosis for COPD. These results might suggest that PR improve the prognosis of patients with COPD.

Research Products

• [Journal Article] (2009)
  • Author(s): 大石修司(塩谷隆信、高橋仁美編著)
  • Journal Title: 現場の疑問に答える呼吸リハビリ徹底攻略Q&A(中外医学社) Pages: 7-12
• [Journal Article] (2009)
  • Author(s): 大石修司(大野秀樹、木崎節子編著)
  • Journal Title: 運動と免疫-からだをまもる運動のふしぎ-(ナップ)
• [Presentation] 運動と呼吸器と活性酸素 (2009)
  • Author(s): 大石修司
  • Organizer: 第49回東北防衛衛生学会
  • Place of Presentation: むつ
  • Year and Date: 2009-11-26
• [Presentation] 運動と呼吸器と活性酸素 (2009)
  • Author(s): 大石修司
  • Organizer: 第49回東北防衛衛生学会
  • Place of Presentation: むつグランドホテル(青森県)
  • Year and Date: 2009-11-26
• [Presentation] Effect of pulmonary rehabilitation on serum superoxide dismutase isoenzymes and oxidative stress in patients with COPD. (2009)
  • Author(s): OHISHI, S.
  • Organizer: European Respiratory Society Annual Congress 2009
  • Place of Presentation: Vienna
  • Year and Date: 2009-09-15
• [Presentation] 慢性閉塞性肺疾患(COPD)患者へのチオトロピウム吸入療法は酸化ストレスを軽減するか? (2009)
  • Author(s): 伊藤昌之
  • Organizer: 第49回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-14
• [Presentation] 慢性閉塞性肺疾患(COPD)患者へのチオトロピウム吸入療法は酸化ストレスを軽減するか? (2009)
  • Author(s): 伊藤昌之
  • Organizer: 第49回日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-06-14
• [Presentation] COPDのリハビリテーションにおけるSODアイゾザイム測定の意義 (2008)
  • Author(s): 伊藤昌之
  • Organizer: 第48回日本呼吸器学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2008-06-16
• [Presentation] COPDのリハビリテーションにおけるSODアイソザイム測定の意義 (2008)
  • Author(s): 伊藤昌之
  • Organizer: 第48回日本呼吸器学会総会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Book] 現場の疑問に答える呼吸リハビリ徹底攻略Q&A (2009)
  • Author(s): 大石修司
  • Publisher: 中外医学社
• [Book] 運動と免疫 (2009)
  • Author(s): 大石修司
  • Publisher: ナップ