Preparation of Oligomeric Proanthocyanidin from Persimmon and Its Anti-Aging Characterization

• Project/Area Number: 19500661
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Toyama
• Principal Investigator: YOKOZAWA Takako University of Toyama, 和漢医薬学総合研究所, 准教授 (90019133)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 柿 / ポリフェノール / オリゴマー / 加齢 / 寿命 / 記憶 / VEGFR-2 / 機能性食品

Research Abstract

柿高分子ポリフェノール(タンニン)を原料とし、新しい低分子化技術によって柿ポリフェノールオリゴマーを製造し、抗加齢機能性素材としての可能性を明らかにした。

Research Products

• [Journal Article] Effects of Proanthocyanidin Preparations on Hyperlipidemia and Other Biomarkers in Mouse Model of Type 2 Diabetes (2008)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T.
  • Journal Title: J. Agric. Food Chem 56 Pages: 7781-7789
  • Peer Reviewed
• [Journal Article] Protective Effect of Persimmon (Diospyros Kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence (2008)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T
  • Journal Title: Biol. Pharm. Bull 31 Pages: 1265-1269
  • NAID: 110006684352
  • Peer Reviewed
• [Journal Article] Effects of Proanthocyanidin Preparations on Hyperlipidemia and Other Biomarkers in Mouse Model of Type 2 Diabetes (2008)
  • Author(s): Lee Y. A, Cho E. J., Yokozawa T.
  • Journal Title: J. Agric. Food Chem. 56 Pages: 7781-7789
  • Peer Reviewed
• [Journal Article] Protective Effect of Persimmon (Diospyros Kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence (2008)
  • Author(s): Lee Y. A, Cho E. J., Yokozawa T.
  • Journal Title: Biol. Pharm. Bull. 31 Pages: 1265-1269
  • NAID: 110006684352
  • Peer Reviewed
• [Journal Article] Preparation, Characterization, and Antioxidative Effects of Oligomeric Proanthocyanidin-L-Cysteine Complexes (2007)
  • Author(s): Fujii H., Nakagawa T., Nishioka H., Sato E., Hirose A., Ueno Y., Sun B., Yokozawa T., Nonaka G
  • Journal Title: J. Agric. Food Chem 55 Pages: 1525-1531
  • Peer Reviewed
• [Journal Article] Inhibitory Activities of Proanthocyanidines from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes (2007)
  • Author(s): Lee Y.A, Cho E.J., Tanaka T., Yokozawa T
  • Journal Title: J. Nutr. Sci. Vitaminol 55 Pages: 287-292
  • NAID: 110006317290
  • Peer Reviewed
• [Journal Article] Protective effect of persimmon peel polyphenol against high glucose- induced oxidative stress in LLC-PK_1 cells (2007)
  • Author(s): Yokozawa T., Kim Y.A., Kim H.Y., Lee Y.A, Nonaka G
  • Journal Title: Food Chem. Toxicol 45 Pages: 1979-1987
  • Peer Reviewed
• [Journal Article] Ameliorative Effects of Proanthocyanidin on Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats (2007)
  • Author(s): Lee Y.A, Kim Y.J., Cho E.J., Yokozawa T
  • Journal Title: J. Agric. Food Chem 55 Pages: 9395-9400
  • Peer Reviewed
• [Journal Article] Preparation, Characterization, and Antioxidative Effects of Oligomeric Proanthocyanidin-L-Cysteine Complexes (2007)
  • Author(s): Fujii H., Nakagawa T., Nishioka H., Sato E., Hirose A., Ueno Y., Sun B., Yokozawa T., Nonaka G.
  • Journal Title: J. Agric. Food Chem 55 Pages: 1525-1531
  • Peer Reviewed
• [Journal Article] Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes (2007)
  • Author(s): Lee Y.A, Cho E.J., Tanaka T., Yokozawa T.
  • Journal Title: J. Nutr. Sci. Vitaminol 53 Pages: 287-292
  • NAID: 110006317290
  • Peer Reviewed
• [Journal Article] Protective effect of persimmon peel polyphenol against high glucose induced oxidative stress in LLC-PK_1cells (2007)
  • Author(s): Yokozawa T., Kim Y.A., Kim H.Y. Lee Y.A. Nonaka G.
  • Journal Title: Food Chem. Toxicol 45 Pages: 1979-1987
  • Peer Reviewed
• [Journal Article] Amehorative Effects of Proanthocyanidin on Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats (2007)
  • Author(s): Lee Y.A, Kim Y.J., Cho E.J., Yokozawa T.
  • Journal Title: J. Agric. Food Chem 55 Pages: 9395-9400
  • Peer Reviewed
• [Journal Article] Modulation of Oxidative Stress and Melanogenesis by Proanthocyanidins
  • Author(s): Kim Y.J., Yokozawa T
  • Journal Title: Biol. Pharm. Bull (in press)
  • NAID: 130000117209
  • Peer Reviewed
• [Presentation] 柿果実のプロアントシアニジンオリゴマーによる抗老化作用 (2008)
  • Author(s): 李英娥, 横澤隆子
  • Organizer: 第20回腎とフリーラジカル研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-20
• [Presentation] Anti-Aging Effects of Oligomeric Proanthocyanidin Isolated from Persimmon Fruits (2008)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T
  • Organizer: The 12th International Conference on Oriental Medicine of Dong-Eui & Daegu Haany University
  • Place of Presentation: Busan, Korea
  • Year and Date: 2008-08-21
• [Presentation] Improved Effects and Its Mechanism of Oligomeric Proanthocyanidins Isolated from Persimmon against Memory Impairment (2008)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T.
  • Organizer: 2008 International Symposium and Annual Meeting "Chronic Disease and LOHAS Foods"
  • Place of Presentation: Jeju Island, Korea
• [Presentation] 柿ポリフェノールの2型糖尿病モデルによる検討 (2008)
  • Author(s): 李英娥, 趙恩珠, 田中隆, 横澤隆子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] 老化促進モデルマウスの記憶障害に対する柿ポリフェノールオリゴマーの影響 (2008)
  • Author(s): 李英娥, 趙恩珠, 田中隆, 東田千尋, 横澤隆子
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
• [Presentation] Improved Effects and Its Mechanism of Oligomeric Proanthocyanidins Isolated from Persimmon against Memory Impairment (2008)
  • Author(s): Lee Y. A, Cho E. J., Yokozawa T.
  • Organizer: 2008 International Symposium and Annual Meeting “Chronic Disease and LOHAS Foods"
  • Place of Presentation: Jeju Island, Korea
• [Presentation] Protective Effects of Proanthocyanidin from Persimmon Peel on Oxidative Stress and Inflammation in Diabetic Rats (2007)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T.
  • Organizer: The Korean Nutrition Society International Conference in Commemoration of the 40th Anniversary
  • Place of Presentation: Seoul, Korea
• [Presentation] Protective Eflbcts of Proanthocyanidin from Persimmon Peel on Oxidative Stress and Inflammation in Diabetic Rats (2007)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T.
  • Organizer: The Korean Nutrition Society International Conference in Commemoration of the 40th Anniversary
  • Place of Presentation: ソウル
• [Book] 腎とフリーラジカル-第9集 (2008)
  • Author(s): Lee Y.A, Cho E.J., Yokozawa T.
  • Publisher: 東京医学社
• [Book] 腎とフリーラジカルー第9集 (2008)
  • Author(s): Lee Y. A, Cho E. J., Yokozawa T.
  • Publisher: 東京医学社
• [Patent(Industrial Property Rights)] 柿ポリフェノールオリゴマー (2007)
  • Inventor(s): 横澤隆子, 田中隆, 太田富久, 奥村文男, 布沢哲二
  • Industrial Property Rights Holder: 明治薬品株式会社
  • Industrial Property Number: 2007-165247
  • Filing Date: 2007-06-22
• [Patent(Industrial Property Rights)] 柿ポリフェノールオリゴマー (2007)
  • Inventor(s): 横澤 隆子, 田中 隆, 太田 富久, 奥村 文男, 布沢 哲二
  • Industrial Property Rights Holder: 明治薬品株式会社
  • Industrial Property Number: 2007-165247
  • Filing Date: 2007-06-22