| Project/Area Number |
19500687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
KAWAKAMI Takayo Okayama Prefectural University, 保健福祉学部・栄養学科, 准教授 (10254567)
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| Co-Investigator(Kenkyū-buntansha) |
村上 泰子 岡山県立大学, 保健福祉学部, 助教 (90326413)
沖田 美佐子 奈良女子大学, 生活環境学部, 特任教授 (70079242)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Yasuko 福山大学, 生命工学部, 講師 (90326413)
OKITA Misako 奈良女子大学, 生活環境学部, 特任教授 (70079242)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 非アルコール性脂肪性肝炎 / 抗酸化ビタミン / 亜鉛 / エイコサペンタエン酸 |
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| Research Abstract |
Nonalcoholic steatohepatitis (NASH) is often associated with obesity, insulin resistance and hypertriglyceridemia. The effect of matrix metalloproteinase activation-9 activation and migration in response to zinc deficiency of hepatic stellate cell was studied to reveal the mechanism of liver fibrosis. The results of this study show that the depletion of cellular zinc levels may induce degradation of extracellular matrix and HSC spreading within the space of Disse. We investigated the effects of antioxidant vitamin and/or EPA supplementation on clinical observations in NASH patients. After 12 weeks, the serum alanine aminotransferase (ALT) level in the Vitamin group was improved, whereas control and EPA group did not show any change. These observations suggest the beneficial effect of antioxidant vitamin supplementation, but not in combination with EPA, which might be associated with body fat.
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