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Research of nutritional treatment for chronic liver disease

Research Project

Project/Area Number 19500688
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNara Women's University

Principal Investigator

OKITA Misako  Nara Women's University, 生活環境学部, 特任教授 (70079242)

Co-Investigator(Kenkyū-buntansha) TSUKAMOTO Ikuyo  奈良女子大学, 生活環境学部, 教授 (20144636)
TOMIOKA Kayoko  岡山県立大学, 保健福祉学部, 准教授 (90368671)
KAWAKAMI Takayo  岡山県立大学, 保健福祉学部, 准教授 (10254567)
MURAKAMI Yasuko  福山大学, 生命工学部, 講師 (90326413)
YOKOYAMA Junko  奈良女子大学, 生活環境学部, 特任准教授 (60389038)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsC型慢性肝炎 / 非アルコール性脂肪肝炎 / エイコサペンタエン酸 / 亜鉛 / ビタミンE / 血中脂肪酸組成 / 免疫能 / 非アルコール性脂肪性肝疾患(NAFLD) / 非アルコール性脂肪肝炎(NASH) / 血漿脂肪酸組成 / サイトケラチン18M30 / ジホモ-γ-リノレン酸 / NAFLD / NASH / 食事療法 / CK-18 / 赤血球膜脂肪酸組成 / 脂肪肝 / 脂肪酸
Research Abstract

(1)Nutritional treatment with EPA or zinc for chronic hepatitis C patients was evaluated. ALT was improved by zinc administration and decrease of lymphocyte counts was prevented by EPA supplementation. Zinc and EPA supplementation were suggested to be useful in the therapy for chronic hepatitis C. (2)In nonalcoholic steatohepatitis, fish intake and vitamin E and C supplementation were suggested to be helpful for the treatment.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (37 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (27 results)

  • [Journal Article] 非アルコール性脂肪肝炎(nonalcoholic steatohepatitis, NASH)患者における魚類摂取の効果2010

    • Author(s)
      川島愛子、菅原詩緒理、稗万美子、沖田美佐子、萬谷育子、北出光輝、吉治仁志、福井博、塚本幾代
    • Journal Title

      日本臨床栄養学会誌 31(1,2,3)

      Pages: 1-8

    • NAID

      10029420962

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 非アルコール性脂肪性肝炎(NASH)患者における食事療法と抗酸化ビタミンおよびEPA投与の影響2010

    • Author(s)
      川上貴代、村上泰子、冨岡加代子、沖田美佐子
    • Journal Title

      日本臨床栄養学会誌 31(1,2,3)

      Pages: 32-37

    • NAID

      10029421046

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 非アルコール性脂肪肝炎(nonalcoholic steatohepatitis, NASH)患者における魚類摂取の効果2010

    • Author(s)
      川島愛子、菅原詩緒理、稗万美子、沖田美佐子、萬谷育子, 他
    • Journal Title

      日本臨床栄養学会誌 31

      Pages: 1-8

    • NAID

      10029420962

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非アルコール性脂肪性肝炎(NASH)患者における食事療法と抗酸化ビタミンおよびEPA投与の影響2010

    • Author(s)
      川上貴代、村上泰子、冨岡加代子、沖田美佐子
    • Journal Title

      日本臨床栄養学会誌 31

      Pages: 32-37

    • NAID

      10029421046

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma fatty acid composition, estimated desaturase activities, and nutritional intake in Japanese men with abdominal obesity or metabolic syndrome.2009

    • Author(s)
      Aiko Kawashima, Shiori Sugawara, Misako Okita, Takemi Akahane, Kenichi Fukui, Maiko Hachiuchi, Chieko Kataoka,, Ikuyo Tsukamoto
    • Journal Title

      J Nutr Sci Vitaminol 55

      Pages: 400-406

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma fatty acid composition, estimated desaturase activities, and nutritional intake in Japanese men with abdominal obesity or metabolic syndrome.2009

    • Author(s)
      Aiko Kawashima, Shiori Sugawara, Misako Okita, Takemi Akahane, Kenichi Hukui, et al.
    • Journal Title

      J Nutr Sci Vitaminol 55

      Pages: 400-406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eicosapentenoic acid supplementation for chronic hepatitis C patients during combination therapy of pegylated interferonα-2b and ribavirin2008

    • Author(s)
      Aiko Kawashima, Ikuyo Tsukamoto, Tomoko Koyabu, Yasuko Murakami, Takayo Kawakami, Naoko Kakibuchi, Kouichi Takaguchi, Keiji Kita, Misako Okita
    • Journal Title

      Lipids 43

      Pages: 325-333

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid supplementation for chronic hepatitis C patients during combination therapy of pegylated interferon α-2b and ribavirin2008

    • Author(s)
      Aiko Kawashima
    • Journal Title

      Lipids 43

      Pages: 325-333

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferonα-2b and ribavirin2007

    • Author(s)
      Yasuko Murakami, Tomoko Koyabu, Aiko Kawashima, Naoko Kakibuchi, Takayo Kawakami, Kouichi Takaguchi, Keiji Kita, Misako Okita
    • Journal Title

      J Nutr Sci Vitaminol 53

      Pages: 213-218

    • NAID

      110006317280

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc supplementation prevents the increase of transaminase in chronichepatitis C patients during combination therapy with pegylated interferon α-2b and ribavirin.2007

    • Author(s)
      Yasuko Murakami
    • Journal Title

      J Nutr Sci Vitaminol 53

      Pages: 213-218

    • NAID

      110006317280

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Significance of serum cytokeratin-18 fragment levels in middle-aged males with nonalcoholic fatty liver disease (NAFLD).2009

    • Author(s)
      Mayumi Hayashi, Misako Okita, Ikuyo Tsukamoto, Kayoko Tomioka, Takayo Kawakami, Yasuko Murakami, Makoto Hiramatsu, Tatsuya Itoshima
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Dihomo-γ-linoleic acid level in plasma phospholipids of middle-aged male with abdominal obesity and fatty liver.2009

    • Author(s)
      Kayoko Tomioka, Misako Okita, Mayumi Hayashi, Yasuko Murakami, Takayo Kawakami, Miharu Kakimoto, Toshiko Nakayama, Makoto Hiramatsu, Tatsuya Itoshima, Ikuyo Tsukamoto
    • Organizer
      9th Int Congress Nutr
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Significance of serum sytokeratin-18 fragment levels in middle-agedmales with nonalcoholic fatty liver disease (NAFLD).2009

    • Author(s)
      Mayumi Hayashi, Misako Okita, Ikuyo Tsukamoto, et al.
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dihomo-γ-linolenic acid level in plasma phospholipids of middle-agedmale with abdominal obesity and fatty liver.2009

    • Author(s)
      Kayoko Tomioka, Misako Okita, Mayumi Hayashi, et al.
    • Organizer
      19th International Congress of Nutrition
    • Place of Presentation
      Bangkok
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非アルコール性脂肪肝炎(NASH)患者における魚類摂取の効果2009

    • Author(s)
      川島愛子、菅原詩緒理、沖田美佐子、萬谷育子、塚本幾代
    • Organizer
      第56回日本栄養改善学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における栄養素摂取状況と脂肪酸代謝2009

    • Author(s)
      菅原詩緒理、川島愛子、稗万美子、沖田美佐子、塚本幾代
    • Organizer
      第56回日本栄養改善学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 血中トランス脂肪酸と腹部肥満および脂肪肝に関する考察2009

    • Author(s)
      冨岡加代子、田村加奈子、村上泰子、林真愉美、川上貴代、片山敬子、森美和子、沖田美佐子
    • Organizer
      第56回日本栄養改善学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-03
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 肥満男性における栄養素摂取状況と血中脂肪酸組成の検討2009

    • Author(s)
      川島愛子、菅原詩緒理、山崎真理子、沖田美佐子、赤羽たけみ、塚本幾代
    • Organizer
      第61回日本家政学会
    • Place of Presentation
      西宮
    • Year and Date
      2009-08-31
    • Related Report
      2009 Final Research Report
  • [Presentation] 肥満男性における栄養素等摂取状況と血中脂肪酸組成の検討2009

    • Author(s)
      川島愛子、菅原詩緒理, 他
    • Organizer
      第61回日本家政学会
    • Place of Presentation
      西宮
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of EPA supplementation on immunological parameters in chronic hepatitis C patients.2008

    • Author(s)
      Aiko Kawashima, Ikuyo Tsukamoto, Misako Okita, Tomoko Koyabu, Yasuko Murakami, Takayo Kawakami, Naoko Kakibuchi, Kouichi Takaguchi, Keiji Kita
    • Organizer
      15th Int Congress Dietetics
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] EPA supplementation for chronic hepatitis C patients during combination therapy of pegylated interferon α-2b and ribavirin2008

    • Author(s)
      Aiko Kawashima
    • Organizer
      15th International Congress of Dietetics
    • Place of Presentation
      横浜市
    • Year and Date
      2008-09-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪肝における栄養素等摂取状況と血中脂肪酸組成の検討2008

    • Author(s)
      川島愛子、稗万美子、竹内優、沖田美佐子、塚本幾代
    • Organizer
      第55回日本栄養改善学会学術総会
    • Place of Presentation
      鎌倉
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] メタボリックシンドロームの血清活性酸素消去能(ORAC)の検討2008

    • Author(s)
      三河麻里、冨岡加代子、林真愉美、村上泰子、川上貴代、中山敏子、沖田美佐子
    • Organizer
      第55回日本栄養改善学会学術総会
    • Place of Presentation
      鎌倉
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] メクボリックシンドロームの血清活性酸素消去能(ORAC)の検討2008

    • Author(s)
      三河 麻里
    • Organizer
      第55回日本栄養改善学会学術総会
    • Place of Presentation
      鎌倉市
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪肝における栄養素等摂取状況と血中脂肪酸組成の検討2008

    • Author(s)
      川島 愛子
    • Organizer
      第55回日本栄養改善学会学術総会
    • Place of Presentation
      鎌倉市
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪肝における血清サイトケラチン- 18の上昇2008

    • Author(s)
      林真愉美、沖田美佐子、塚本幾代、冨岡加代子、川上貴代、村上泰子、平松信、糸島達也
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      坂戸
    • Year and Date
      2008-05-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 健診における肥満者の血漿脂肪酸組成の検討2008

    • Author(s)
      冨岡加代子、川上貴代、村上泰子、林真愉美、沖田美佐子、塚本幾代、平松信、糸島達也
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      坂戸
    • Year and Date
      2008-05-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 健診受診者における栄養素摂取状況とメタボリックシンドロームとの関連2008

    • Author(s)
      川島愛子、竹内優、沖田美佐子、塚本幾代、赤羽たけみ、福居健一、橋内麻衣子、片岡智栄子、白井康代
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      坂戸
    • Year and Date
      2008-05-04
    • Related Report
      2009 Final Research Report
  • [Presentation] メタボリックシンドロームにおける易血栓性に関連する因子の検討.2008

    • Author(s)
      赤羽たけみ、川島愛子、福居健一、橋内麻衣子、片岡智栄子、白井康代、沖田美佐子、塚本幾代、福井博
    • Organizer
      第105回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-11
    • Related Report
      2009 Final Research Report
  • [Presentation] メタボリツクシンドロームにおける易血栓性に関連する因子の検討2008

    • Author(s)
      赤羽 たけみ
    • Organizer
      第105回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] C型慢性肝炎の治療における抗酸化ビタミンとエイコサペンタエン酸の補給効果2007

    • Author(s)
      川島愛子
    • Organizer
      第29回日本臨床栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎患者における食事療法と抗酸化ビタミンおよびEPA投与の影響2007

    • Author(s)
      川上貴代、笹埜三世里、鈴木麻衣、森本祥代、春名瑞保、大室里衣、木下真貴、村上泰子、冨岡加代子、稲田暢、山田剛太郎、沖田美佐子
    • Organizer
      第29回日本臨床栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] パネルディスカッション「EBMからみたファーマコロジカル・ニュートリションの臨床応用」-C型慢性肝炎の治療における抗酸化ビタミンとエイコサペンタエン酸の補給効果-2007

    • Author(s)
      川島愛子、塚本幾代、小薮智子、村上泰子、川上貴代、冨岡加代子、垣渕直子、高口浩一、喜田恵治、沖田美佐子
    • Organizer
      第29回日本臨床栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] EPA supplementation for the treatment of chronic hepatitis C.2007

    • Author(s)
      Aiko Kawashima, Ikuyo Tsukamoto, Tomoko Koyabu, Yasuko Murakami, Takayo Kawakami, Misako Okita, Naoko Kakibuchi, Kouichi Takaguchi, Keiji Kita
    • Organizer
      10th Asian Congress of Nutrition
    • Place of Presentation
      Taipei
    • Year and Date
      2007-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Serum lysophospholipids and fatty acid moieties in liver cirrhosis2007

    • Author(s)
      Takayo Kawakami, Miwa Kawanaka, Aiko Kawashima, Yasuko Murakami, Gohichi Niiyama, Gotaro Yamada, Misako Okita
    • Organizer
      10th Asian Congress of Nutrition
    • Place of Presentation
      Taipei
    • Year and Date
      2007-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] EPA supplementation for the treatment of chronic hepatitis C2007

    • Author(s)
      Aiko Kawashima
    • Organizer
      10th Asian Congress of Nutrition
    • Place of Presentation
      台北
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Serum lysophospholipids and fatty-acid moieties in liver cirrhosis2007

    • Author(s)
      Takayo Kawakami
    • Organizer
      10th Asian Congress of Nutrition
    • Place of Presentation
      台北
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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