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Serum levels of retinol and other antioxidants for hearing impairment among Japanese older adults

Research Project

Project/Area Number 19500692
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionKeio University

Principal Investigator

NISHIWAKI Yuji  Keio University, 医学部, 講師 (40237764)

Co-Investigator(Kenkyū-buntansha) TAKEBAYASHI Toru  慶應義塾大学, 医学部, 教授 (30265780)
ASAKURA Keiko  慶應義塾大学, 医学部, 助教 (40306709)
SAITO Hideyuki  慶應義塾大学, 医学部, 講師 (10235062)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords予防医学 / 栄養学 / 抗酸化物質 / 加齢性難聴 / 老化 / 酸化ストレス
Research Abstract

65歳以上の地域在住高齢者約800名を対象に8種類の血清抗酸化物質測定と聴力検査を実施し、時間断面解析から血清レチノール濃度およびプロビタミンA濃度が高くなるに従い、加齢性難聴者の割合が低下することを明らかにした。これまでに、Population-basedな疫学デザインにより抗酸化物質レベルと加齢性難聴の関連を調査した疫学研究は国内外になく、本研究が初のエビデンスと思われる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Serum Levels of Retinol and Other Antioxidants for Hearing Impairment among Japanese Older Adults.2009

    • Author(s)
      Michikawa T
    • Journal Title

      J Gerontol A Biol Sci Med Sci in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults

    • Author(s)
      Michikawa T, Nishiwaki Y, Kikuchi Y, Hosoda K, Mizutari K, Saito H, Asakura K, Milojevic A, Iwasawa S, Nakano M, Takebayashi T.
    • Journal Title

      J Gerontol A Biol Sci Med Sci (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Vitamin A and Age-related Hearing Loss among Older Japanese2008

    • Author(s)
      Takehiro Michikawa
    • Organizer
      136th American Public Health Association
    • Place of Presentation
      San Diego
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Vitamin A and Age-related Hearing Loss among Older Japanese.2008

    • Author(s)
      Takehiro Michikawa
    • Organizer
      136th American Public Health Association
    • Place of Presentation
      San Diego
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 地域在住高齢者における抗酸化質濃度と聴力の比較検討2007

    • Author(s)
      水足 邦雄
    • Organizer
      第1回聴覚アンチエイジング研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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