Mechanism involved in brain vessel impairments caused by salt over intake

• Project/Area Number: 19500699
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kinki University
• Principal Investigator: HIGASHINO Hideaki Kinki University, 医学部, 教授 (40122098)
• Co-Investigator(Kenkyū-buntansha): NIWA Atsuko 近畿大学, 医学部, 講師 (60122082) ; TABUCHI Masaki 近畿大学, 医学部, 助教 (20340771) ; OOSHIMA Kana 近畿大学, 医学部, 助手 (60278653)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 健康と食生活 / 食塩負荷 / 脳血管 / 腎血管 / mRNA発現 / DNAアレイ / SHR / TCM / 副腎 / 食塩 / 血管 / 脳 / 腎臓 / 血圧 / 脳卒中 / 動脈肥厚 / SHRSP

Research Abstract

M-SHRSP given the food containing 0.2% sodium chloride showed lower incidences of brain stroke, lower fatal rates, lighter pathological changes in cerebral vessel than those of the rats feed foods containing much salt. M-SHRSP given 3.0% trichloro-methiazide (TCM) were inhibited the incidence of brain stroke. The expressions of eNOS, and nNOS mRNAs were elevated, and NOx1 and p22phox RNAs, superoxide production and fibrous changes in the kidney were inhibited by dosing of TCM. KS, Sgne1 mRNAs were increased at the cortex of kidney in 6- and 9-week-old WKY and SHRSP given 4.0% sodium chloride for 2 days. New knowledge regarding unfavorable salt effects was obtained as above.

Research Products

• [Journal Article] Gene expression in the adrenal glands of three spontaneously hypertensive rat substrains (2010)
  • Author(s): MS. Ashenagar, M.. Tabuchi, K. Kinoshita, K. Ooshima, A. Niwa,, Y. Watanabe, M. Yoshida, K. Shimada, T. Yasunaga, H. Yamanishi, H. Higashino
  • Journal Title: Molecular Medicine Reports Vol.3,No.2 Pages: 213-222
  • Peer Reviewed
• [Journal Article] Gene expression in the adrenal glands of three spontaneously hypertensiverat substrains (2010)
  • Author(s): Ashenagar MS, Tabuchi M, Kinoshita K, Ooshima k, Higashino H
  • Journal Title: Mol Med Reports 3 Pages: 213-222
  • Peer Reviewed
• [Journal Article] Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats (2008)
  • Author(s): T. Ishizuka, A. Niwa, M. Tabuchi, K. Ooshima, H. Higashino
  • Journal Title: Life Science Vol.82 Pages: 806-815
  • Peer Reviewed
• [Journal Article] Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats (2008)
  • Author(s): Ishizuka T, Niwa A, Tabuchi, M, Ooshima K, Higashino H
  • Journal Title: Life Science 82 Pages: 806-815
  • Peer Reviewed
• [Journal Article] Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats (2007)
  • Author(s): T. Ishizuka, A. Niwa, M. Tabuchi, Y. Nagatani, K. Ooshima, H. Higashino
  • Journal Title: J Hypertens Vol.25,No.4 Pages: 861-870
  • Peer Reviewed
• [Journal Article] Involvement of thromboxane A2 receptor in the cerebrovascular damage.damage of salt-loaded, stroke-prone rats (2007)
  • Author(s): Ishizuka T, Niwa A, Tabuchi M, Nagatani Y, Ooshima, Higashino H
  • Journal Title: J hypertension 25 Pages: 861-870
  • Peer Reviewed
• [Journal Article]
  • Author(s): http:/www. med. kindai. ac. jp