| Project/Area Number |
19500704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
AOMINE Masahiro Nakamura Gakuen College, 栄養科学部, 教授 (60091261)
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| Co-Investigator(Kenkyū-buntansha) |
YAMATO Takako 中村学園大学, 栄養科学部, 准教授 (70271434)
NISHIYAMA Atsuko 中村学園大学, 栄養科学部, 助手 (90461475)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 食行動 / ストレス / 摂食障害 / 神経伝達物質 / 血糖値 / 運動量 / マイクロダイアリシス / ラット / 行動量 / 学習記憶 / 糖尿病 / 食欲減退 |
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| Research Abstract |
We studied the mechanism underlying stress-induced anorexia by measuring brain serotonin (5-HT), the locomotor activity, the intakes of food and water, and the nitric oxide (NO) in rats and mice. Immobilization, electric stimulation and alcohol administration were used as stress. The stress caused the dysfunction of 5-HT3 and 5-HT4 receptors. These stresses during active stage in a day significantly decreased the contents of food intake and the locomotor activity. Further, higher level of blood glucose concentration, which was induced by diabetes mellitus, reduced the resistance for the stress, while the relation between the resistance for stress and NO remains obscure.
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