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Studies on the safety and efficacy of the simultaneous intake of the functional food.

Research Project

Project/Area Number 19500710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

NAGATA Junichi  National Institute of Health and Nutrition, 食品保健機能プログラム, プロジェクトリーダー (70237527)

Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords食生活 / 健康 / 機能性食品 / 組み合せ / 組み合わせ / 有効性 / 安全性
Research Abstract

In this study, we examined the beneficial function and the health effect of the functional food components or the so-called health foods in rats and mice. As a result, we could not observe the beneficial function in rats fed the excess amount of the so-called health food, although the excess intake did not influence any health effects such as growth and liver functions. On the other hand, the combinational intake of functional food components did not indicate the additive and/or synergetic effect or the cancel effect in rats and mice fed the experimental diets, although the individual component showed the certain beneficial function. In addition, we also did not observed any health effects in the appropriate use of the functional components. These results indicate that the combinational intake of the functional food components with similar health benefits does not show necessarily the better-than-expected performance. In addition, the functionality of the so-call health food is not clear even in the excess intake.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Products Report
  • Research Products

    (49 results)

All 2010 2009 2008 2007 Other

All Journal Article (20 results) (of which Peer Reviewed: 12 results) Presentation (25 results) Remarks (4 results)

  • [Journal Article] Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1{alpha}mRNA : a role of{beta}2-adrenergic receptor activation.2010

    • Author(s)
      Tadaishi M, Miura S, Kai Y, Kawasaki E, Koshinaka K, Kawanaka K, Nagata J, Oishi Y, Ezaki O
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 300

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of simultaneous intakes of soybean protein and diacylglycerol on lipid profiles and body fat accumulation in rats.2009

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Biosci. Biotechnol. Biochem. 73

      Pages: 1328-1332

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of simultaneous intakes of soybean protein and diacylglycerol on lipid profiles and body fat accumulation in rats2009

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Biosci.Biotechnol.Biochem. 73(6)

      Pages: 1328-1332

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effects of simultaneous intakes of soybean protein and diacylglycerol on lipid profiles and body fat accumulation in rats.2009

    • Author(s)
      Nagata J, Yamada K
    • Journal Title

      Biosci. Biotechnol. Biochem. 73

      Pages: 1328-1332

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of simultaneous intakes of soybean protein and diacylglycerol on lipid profiles and body fat accumulation in rats.2009

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 72 Pages: 1328-1332

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] Foods with Health Claims in Japan.2008

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Food Sci.Technol.Res. 14

      Pages: 519-524

    • Related Report
      2010 Final Research Report
  • [Journal Article] Foods with Health Claims in Japan2008

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Food Sci.Technol.Res. 14(6)

      Pages: 519-524

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Improved Analytical Precision of 1, 4-Dihydroxy-2-naphthoic Acid by High Performance Liquid Chromatography Using Dithiothreitol as a Mobile Phase Additive2008

    • Author(s)
      Takebayashi J, Nagata J, Yamada K.
    • Journal Title

      Food Sci.Technol.Res. 14(5)

      Pages: 509-512

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 特定健康診査および特定保健指導と特定保健用食品の役割2008

    • Author(s)
      永田純一
    • Journal Title

      食品加工と包装技術 ジャパンフードサイエンス Vol.47、No.7

      Pages: 21-26

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Foods with Health Claims in Japan2008

    • Author(s)
      Junichi Nagata, Kazuhiko Yamada
    • Journal Title

      Food Sci. Technol. Res. 14

      Pages: 519-524

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved Analytical Precision of 1, 4-Dihydroxy-2-naphthoic Acid by High Performance Liquid Chromatography Using Dithioth reitol as a Mobile Phase Additive2008

    • Author(s)
      Jun Takebayashi, Junichi Nagata, Kazuhiko Yamada
    • Journal Title

      Food Sci. Technol. Res. 14

      Pages: 509-512

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Health Claim Evidence Requirements in Japan2008

    • Author(s)
      Kazuhiko Yamada, Natsuko Sato-Mito, Junichi Nagata, Keizo Umegaki
    • Journal Title

      J. Nutr. 138

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] トランス脂肪酸に関する最近の話題-国際的な動向と国内の現状について2008

    • Author(s)
      永田純一
    • Journal Title

      日本食生活学会誌 18

      Pages: 211-215

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 機能性構造油脂と生活習慣病改善効果2008

    • Author(s)
      永田純一
    • Journal Title

      日本医師会雑誌 137

      Pages: 2409-2409

    • Related Report
      2008 Annual Research Report
  • [Journal Article] トランス脂肪酸の国内外における規制状況2008

    • Author(s)
      永田純一, 山田和彦
    • Journal Title

      生物と化学 46

      Pages: 672-673

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特定健康審査および特定保健指導と特定保健用食品の役割2008

    • Author(s)
      永田純一
    • Journal Title

      ジャパンフードサイエンス 47

      Pages: 21-26

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Foods with Health Claims in Japan.2008

    • Author(s)
      Nagata J, Yamada K.
    • Journal Title

      Food Sci. Technol. Res.

      Volume: 14 Pages: 519-524

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats.2007

    • Author(s)
      Nagata J, Morino T, Saito M.
    • Journal Title

      J.Nutr.Sci.Vitaminol. 53

      Pages: 133-137

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats2007

    • Author(s)
      Nagata J, Morino T, Saito M.
    • Journal Title

      J.Nutr.Sci.Vitaminol. 53(2)

      Pages: 133-7

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effects of dietary Angelica keiskei on serum and liver lipid profiles, and body fat accumulations in rats.2007

    • Author(s)
      Nagata J, Morino T, Saito M.
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 53 Pages: 133-137

    • Related Report
      Products Report
    • Peer Reviewed
  • [Presentation] In vivo and in vitro studies on physiological functions of Ashitaba (Angelica Keiskei) and their extracts.2010

    • Author(s)
      永田純一, 中村礼, 石見佳子.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-19
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo and in vitro studies on physiological functions of Ashitaba(Angelica Keiskei)and their extracts.2010

    • Author(s)
      Junichi Nagata, Aya Nakamura, Yoshiko Ishimi
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo and in vitro studies on physiological functions of Ashitaba (Angelica Keiskei) and their extracts2010

    • Author(s)
      Nagata J, Nakamura A, Ishimi Y.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-19
    • Related Report
      Products Report
  • [Presentation] 体脂肪低減をもたらす機能性食品素材の摂取が成長期マウス骨密度に及ぼす影響2010

    • Author(s)
      中村礼、石見佳子、永田純一
    • Organizer
      第57回日本栄養改善学会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-09-12
    • Related Report
      2010 Final Research Report Products Report
  • [Presentation] 体脂肪低減をもたらす機能性食品素材の摂取が成長期マウス骨密度に及ぼす影響2010

    • Author(s)
      中村礼、石見佳子、永田純一
    • Organizer
      第57回日本栄養改善学会
    • Place of Presentation
      女子栄養大(埼玉)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Physiological functions of Ashitaba(Angelica Keiskei)and its extracts in vivo and in vitro studies.2010

    • Author(s)
      Junichi Nagata, Aya Nakamura
    • Organizer
      39th UJNR Food and Agriculture Panel Meeting
    • Place of Presentation
      Boltimore(USA)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] β-コングリシニンと中鎖脂肪酸を含む食用油の併用摂取がマウスの体脂肪および脂質代謝に及ぼす影響2010

    • Author(s)
      中村礼、城内文吾、古場一哲、石見佳子、永田純一
    • Organizer
      第64回日本栄養・食糧学会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-23
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report Products Report
  • [Presentation] 特定保健用食品の健康 (強調) 表示について2009

    • Author(s)
      永田純一
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-06
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 特定保健用食品の健康(強調)表示について2009

    • Author(s)
      永田純一
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of Ashitaba (Angelica keiskei) extracts on lipid accumulations and gene expressions related to the lipid metabolism in cultured rat adipocytes.2009

    • Author(s)
      永田純一, 佐賀加奈子, 中村礼, 山田和彦
    • Organizer
      International Congress of Nutrition 2009
    • Place of Presentation
      Bangkok,(Thailand)
    • Year and Date
      2009-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Ashitaba(Angelica keiskei)extracts on lipid accumulations and gene expressions related to the lipid metabolism in cultured rat adipocytes.2009

    • Author(s)
      Nagata J, Saga K, Nakamura A, Yamada K.
    • Organizer
      International Congress of Nutrition 2009
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-10-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of Ashitaba (Angelica keiskei) extracts on lipid accumulations and gene expressions related to the lipid metabolism in cultured rat adipocytes.2009

    • Author(s)
      Nagata J, Saga K, Nakamura A, Yamada K.
    • Organizer
      International Congress of Nutrition 2009
    • Place of Presentation
      Bangkok, (Thailand)
    • Year and Date
      2009-10-08
    • Related Report
      Products Report
  • [Presentation] Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats and Mice.2009

    • Author(s)
      Nagata J, Nakamura A, Shirouchi B, Ishimi Y.
    • Organizer
      38^<th> UJNR Food and Agriculture Panel Meeting.
    • Place of Presentation
      Tsukuba (Japan)
    • Year and Date
      2009-10-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats and Mice.2009

    • Author(s)
      Nagata J, Nakamura A, Shirouchi B, Ishimi Y.
    • Organizer
      38^<th> UJNR Food and Agriculture Panel Meeting
    • Place of Presentation
      つくば
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats and Mice.2009

    • Author(s)
      Nagata J, Nakamura A, Shirouchi B, Ishimi Y.
    • Organizer
      38^<th> UJNR Food and Agriculture Panel Meeting
    • Place of Presentation
      Tsukuba(Japan)
    • Year and Date
      2009-10-05
    • Related Report
      Products Report
  • [Presentation] マウス体脂肪蓄積および脂質代謝関連遺伝子に及ぼす大豆タンパク質とジアシルグリセロール併用摂取の影響2009

    • Author(s)
      中村礼、佐賀加奈子、山田和彦、永田純一
    • Organizer
      第63回日本栄養・食糧学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report Products Report
  • [Presentation] ラット脂肪前駆細胞における明日葉抽出物の脂肪蓄積に対する影響2009

    • Author(s)
      永田純一、佐賀加奈子、中村礼、山田和彦
    • Organizer
      第63回日本栄養・食糧学会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report Products Report
  • [Presentation] Effects of Structured Lipids containing n-3 PUFA and Caprylic Acid on Lipid Profiles and Lymphatic Absorption of Rats.2009

    • Author(s)
      Nagata J
    • Organizer
      100th American Oil Chemists' Society Annual Meeting Symposium
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-05-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of Ashitaba (Angelica keiskei) extracts on lipid accumulations and gene expressions related to the lipid metabolism in cultured rat adipocytes2009

    • Author(s)
      Nagata J, Saga K, Nakamura A, Yamada K.
    • Organizer
      ICN2009
    • Place of Presentation
      Thailand
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Effects of Simultaneous Intake of Soybean Protein and Diacylglycerol on Lipid Profiles and Body Fat Accumulation in Rats and Mice2009

    • Author(s)
      Nagata J, Nakamura A, Shirouchi B, Ishimi Y.
    • Organizer
      38^<th> UJNR Food and Agriculture Panel Meeting
    • Place of Presentation
      Ibaraki, Tsukuba
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 沖縄産カンショ (Ipomoea batatas L.) 茎葉の抗酸化活性に関する研究2009

    • Author(s)
      大嶺和可奈, 平良淳誠, 平良和代, 永田純一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of combination of some functional food components on lipid profiles in rats.2007

    • Author(s)
      永田純一
    • Organizer
      International Conference on Food Factor for Health Promotion.
    • Place of Presentation
      Kyoto (Japan)
    • Year and Date
      2007-11-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of combination of some functional food components on lipid profi les in rats2007

    • Author(s)
      Junichi Nagata
    • Organizer
      International Conference on Food Factor for Health Promotion
    • Place of Presentation
      Kyoto(Japan)
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of combination of some functional food components on lipid profiles in rats.2007

    • Author(s)
      Nagata J
    • Organizer
      International Conference on Food Factor for Health Promotion.
    • Place of Presentation
      Kyoto(Japan)
    • Year and Date
      2007-11-30
    • Related Report
      Products Report
  • [Presentation] Effects of combination of some functional food components on lipid profiles in rats2007

    • Author(s)
      Nagata J, Yamada Y, Saito M.
    • Organizer
      ICoFF 2007
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Self-evaluation Report
  • [Remarks] 研究所定期刊行誌「健康・栄養ニュース」

    • Related Report
      2010 Final Research Report
  • [Remarks] 平成18年3月15日発行第4巻4号(通巻15号) Page 5.

    • Related Report
      2010 Final Research Report
  • [Remarks] 平成19年9月15日発行第6巻2号(通巻21号) Page 6.

    • Related Report
      2010 Final Research Report
  • [Remarks] 平成22年6月15日発行第9巻1号(第32号) Page 6.

    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-09-09  

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