Induction of Genomic Instability Induced by Chromosome Mis-segregation and the Implication on Carcinogenesis
| Project/Area Number |
19510054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
NUNOSHIBA Tatsuo Tohoku University, 大学院・生命科学研究科, 准教授 (10270802)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kazuo 東北大学, 大学院・生命科学研究科, 教授 (20093536)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 放射線生物影響 / ゲノム安定性 / 染色体不均等分配 / 非変異発がん物質 / LOH / phenyl hydroquinone / morphogenesis checkpoint / 染色体異数化 / Aneuploidy / 細胞周期 / 細胞がん化 / 出芽酵母 / 非変異原性発がん物質 |
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| Research Abstract |
非変異発がん物質である輸入柑橘類の防カビ剤o-phenyl phenolの代謝物、phenyl hydroquinone (PHQ)をモデル物質とし、細胞周期と染色体分配機構への影響を検討した。その結果、酵母ではPHQがHog1-Swe1 checkpointを活性化しG2/Mの境界で細胞周期を停止させることが染色体異数化誘発に必要であること、ヒト培養細胞でもPHQが染色体数の異常を誘発することが確認できた。
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin2008
Author(s)
Ikehata H, Kawai K, Komura J, Sakatsume K, Wang L, Imai M, Higashi S, Nikaido O, Yamamoto K, Hieda K, Watanabe M, Kasai H, Ono T.
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Journal Title
J Invest Dermatol 128
Pages: 2289-2296
NAID
Related Report
Peer Reviewed
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[Journal Article] Ames test-negative carcinogen, ortho-phenyl phenol, binds tubulin and causes aneuploidy in budding yeast2007
Author(s)
Nunoshiba T, Watanabe E, Takahashi T, Daigaku Y, Ishikawa S, Mochizuki M, Ui A, Enomoto T, Yamamoto K.
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Journal Title
Mutat Res 617(1-2)
Pages: 90-97
Related Report
Peer Reviewed
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