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The analysis of the dysfunction of p53 in delayed mutation

Research Project

Project/Area Number 19510061
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OKAZAKI Ryuji  University of Occupational and Environmental Health, Japan, 医学部, 講師 (50309960)

Co-Investigator(Kenkyū-buntansha) OOTSUYAMA Akira  産業医科大学, 医学部, 准教授 (10194218)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsp53 / 遅延型突然変異 / 放射線被曝 / アポトーシス / T cell receptor
Research Abstract

加齢現象として種々の突然変異率は増加し、発がんの原因になると考えられている。若年時に放射線被曝していると、突然変異率は遅延型突然変異として顕著にみられる。これは被曝直後に排除されなかったDNA障害が遺伝的不安定性という形で残存し、また加齢ともにp53遺伝子の機能異常が生じるためと考えられ、その機能異常はp53遺伝子の欠失や変異によるものと示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (1 results) Presentation (15 results)

  • [Journal Article] 老化のトピックスーテロメア、ミトコンドリア、p532009

    • Author(s)
      岡崎龍史、大津山彰、法村俊之
    • Journal Title

      放射線生物学研究 (in press)

    • NAID

      40016736305

    • Related Report
      2008 Final Research Report
  • [Presentation] The analysis of p53 sequence in delayed mutation2009

    • Author(s)
      Okazaki R, Ootsuyama A, Mabuchi Y, Suzuki S, Matsuzaki Y, Norimura T.
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      Seoul
    • Related Report
      2008 Final Research Report
  • [Presentation] 遅延型突然変異におけるp53遺伝子配列の解析2008

    • Author(s)
      岡崎龍史, 大津山彰, 法村俊之
    • Organizer
      第51回放射線影響学会
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遅延型突然変異におけるp53遺伝子とその関連遺伝子の動態2008

    • Author(s)
      岡崎龍史
    • Organizer
      第45回放射線影響懇話会
    • Place of Presentation
      長崎
    • Year and Date
      2008-07-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 遅延型突然変異におけるp53遺伝子配列の解析2008

    • Author(s)
      岡崎龍史
    • Organizer
      第45回放射線影響懇話会
    • Place of Presentation
      長崎
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遅延型突然変異におけるp53遺伝子の解析2008

    • Author(s)
      岡崎龍史、大津山彰、法村俊之
    • Organizer
      第51回放射線影響学会
    • Place of Presentation
      北九州
    • Related Report
      2008 Final Research Report
  • [Presentation] 放射線による発がん過程を変えるp53遺伝子の存在状態2008

    • Author(s)
      大津山彰、岡崎龍史、法村俊之
    • Organizer
      第51回放射線影響学会
    • Place of Presentation
      北九州
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 放射線被曝による遅延型突然変異におけるp53遺伝子の解析2007

    • Author(s)
      岡崎龍史、猪狩和之、柿原ひろ代、大津山彰、法村俊之
    • Organizer
      第25回産業医科大学学会
    • Place of Presentation
      北九州
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 放射線障害におけるp53の役割-適応応答と突然変異において-2007

    • Author(s)
      岡崎龍史
    • Organizer
      第44回放射線影響懇話会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] β線による皮膚発がんの発生率と発生時期はp53遺伝子の存在状態に依存2007

    • Author(s)
      大津山彰、岡崎龍史、法村俊之
    • Organizer
      第50回放射線影響学会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report
  • [Presentation] 遅延型突然変異におけるp53遺伝子配列の解析2007

    • Author(s)
      岡崎龍史、大津山彰、法村俊之
    • Organizer
      第50回放射線影響学会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 放射線による発がん率と発生時期はp53遺伝子の存在状態に依存する2007

    • Author(s)
      大津山彰、岡崎龍史、法村俊之
    • Organizer
      第144回日本獣医学会学術集会(日本実験動物医学会)
    • Place of Presentation
      北海道
    • Related Report
      2008 Final Research Report
  • [Presentation] TP53 and TP53-related genes associated with protection from apoptosis in the radio-adaptive response2007

    • Author(s)
      Okazaki R, Ootsuyama A, Norimura T.
    • Organizer
      13th international congress of radiation research,
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Induction and persistence of T-cell receptor (TCR) variants in X-irradiated mice depends on p53 status2007

    • Author(s)
      Norimura T, Kakihara H, Igari K, Okazaki R, Ootsuyama A.
    • Organizer
      13th international congress of radiation research
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Influence of p53 on the induction of mouse skin tumors by repetitive beta-irradiation2007

    • Author(s)
      Ootsuyama A, Okazaki R, Norimura T.
    • Organizer
      13th international congress of radiation research
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of T-cell receptor (TCR) variants and apoptosis induced by beta radiation from tritiated water at low dose rate in different p53 status mice.2007

    • Author(s)
      Umata T, Kunugita N, Okazaki R, Norimura T.
    • Organizer
      13th international congress of radiation research
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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