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Birth and Death of Chemokine Family Genes and Gain of Novel Functions

Research Project

Project/Area Number 19510197
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 基礎ゲノム科学
Research InstitutionKumamoto University

Principal Investigator

NOMIYAMA Hisayuki  Kumamoto University, 大学院・医学薬学研究部, 講師 (00156225)

Co-Investigator(Kenkyū-buntansha) 瀬戸山 千秋  熊本大学, 大学院・医学薬学研究部, 准教授 (60040250)
長田 直樹  独立行政法人医薬基盤研究所, 生物資源研究, 研究員 (70416270)
Co-Investigator(Renkei-kenkyūsha) SETOYAMA Chiaki  熊本大学, 大学院・医学薬学研究部, 准教授 (60040250)
OSADA Naoki  独立行政法人医薬基盤研究所, 生物資源研究部, 研究員 (70416270)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsゲノム進化 / 再編 / ケモカイン / カニクイザル / 翻訳 / 遺伝子重複 / CXCL1L / 偽遺伝子 / 遺伝子発現調節 / CXCL1
Research Abstract

ケモカインファミリー遺伝子は進化速度が特に早い. そのメンバーであるカニクイザル特異的CXCL1L遺伝子は, mRNAは発現するにもかかわらず, タンパク質はほとんど合成しない. その翻訳抑制機構を解析し, ケモカイン遺伝子進化との関係において考察した.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] CCR9 (chemokine (C-C motif) receptor 9)2009

    • Author(s)
      Nomiyama H, Yoshie O.
    • Journal Title

      Atlas Genet Cytogenet Oncol Haematol (electronic)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extensive expansion and diversification of the chemokine gene family in zebrafish : identification of a novel chemokine subfamily CX2008

    • Author(s)
      Nomiyama H, Hieshima K, Osada N, Kato-Unoki Y, Otsuka-Ono K, Takegawa S, Izawa T, Yoshizawa A, Kikuchi Y, Tanase S, Miura R, Kusuda J, Nakao M, Yoshie O.
    • Journal Title

      BMC Genomics (electronic) 222

      Pages: 9-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extensive expansion and diversification of the chemokine gene family in zebrafish: Identification of a novel chemokine subfamily CX2008

    • Author(s)
      Nomiyama, H.
    • Journal Title

      BMC Genomics (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCR9 (chemokine (C-C motif) receptor 9)

    • Author(s)
      Nomiyama, H.
    • Journal Title

      Atlas of Genetics and Cytogeneticsin Oncoloav and Haematoloqy in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 系統特異的重複および欠失によるケモカイン遺伝子ファミリーの急速な進化2008

    • Author(s)
      野見山尚之, 長田直樹, 楠田潤, 義江修
    • Organizer
      日本分子生物学会
    • Place of Presentation
      兵庫県神戸市神戸ポートピアホテル
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] マカク属特異的な新規ケモカイン遺伝子CXCL1L2007

    • Author(s)
      野見山尚之, 長田直樹, 義江修, 楠田潤
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Year and Date
      2007-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] マカク属サル特異的な新規ケモカイン遺伝子CXCL1L2007

    • Author(s)
      代表 野見 山尚之 (代表者)
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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