Exhaustive search of genes that encode useful snake venom proteins for designing new medicine.

• Project/Area Number: 19510201
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 基礎ゲノム科学
• Research Institution: Meiji Pharmaceutical University
• Principal Investigator: ATODA Hideko Meiji Pharmaceutical University, 薬学部, 教授 (20221046)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動物ゲノム / ハブ / ゲノム / 抗凝固タンパク質 / C型レクチン / フォスミドライブラリー / IX-X / bp / IX-bp / 抗凝固蛋白質 / 医薬シーズ / ヘビ毒 / 遺伝子 / 薬学

Research Abstract

I have determined the structure of genes that encode habu IX/X-bp, an anticoagulant protein consisted of two C-type lectin-like chains.

Research Products

• [Journal Article] Anticoagulant mechanism of factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis (2009)
  • Author(s): Midori Ishikawa, Makoto Kumashiro, Yasuo Yamazaki, Hideko Atoda, Takashi Morita
  • Journal Title: J. Biochem. 145 Pages: 123-128
  • NAID: 10024914715
  • Peer Reviewed
• [Journal Article] Anticoagulant mechanism of factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis (2009)
  • Author(s): Midori Ishikawa, et al.
  • Journal Title: J.Biochem. 145 Pages: 123-128
  • Peer Reviewed
• [Journal Article] Anticoagulant mechanism of factor IX/factor X-binding protein isolated from the venom of Trimeresurus flavoviridis. (2009)
  • Author(s): Ishikawa M., et al.
  • Journal Title: Journal of Biochemistry 145 Pages: 123-128
  • Peer Reviewed
• [Journal Article] Adenovirus serotype 5 hexon mediates liver gene transfer. (2008)
  • Author(s): Waddington SN, McVey JH, Bhella D, Parker AL, Barker K, Atoda H, Pink R, Buckley SM, Greig JA, Denby L, Custers J, Morita T, Francischetti IM, Monteiro RQ, Barouch DH, van Rooijen N, Napoli C, Havenga MJ, Nicklin SA, Baker AH
  • Journal Title: Cell 132 Pages: 397-409
  • Peer Reviewed
• [Journal Article] Adenovirus serotype 5 hexon mediates liver gene transfer. (2008)
  • Author(s): Waddington S. N., et al.
  • Journal Title: Cell 132 Pages: 397-409
  • Peer Reviewed
• [Journal Article] Adenovirus serotype 5 hexon mediates liver gene transfer (2008)
  • Author(s): Waddington S.N, et. al.
  • Journal Title: Cell 132 Pages: 397-409
  • Peer Reviewed
• [Presentation] 血液凝固IX因子結合タンパク質a鎖遺伝子の構造 (2010)
  • Author(s): 阿刀田英子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] 血液凝固IX因子結合タンパク質A鎖遺伝子の構造 (2010)
  • Author(s): 阿刀田英子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] 抗凝固作用を有するヘビ毒c型レクチン様ドメインヘテロダイマ-「IX/X-bp」の遺伝子構造 (2009)
  • Author(s): 阿刀田英子
  • Organizer: 第10回Pharmaco-Hematology Symposium
  • Place of Presentation: 東京
  • Year and Date: 2009-06-20
• [Presentation] 抗凝固作用を有するヘビ毒C型レクチン様ドメインヘテロダイマー「IX/X-by」の遺伝子構造 (2009)
  • Author(s): 阿刀田英子
  • Organizer: 第10回 Pharmaco-Hematology Symposium
  • Place of Presentation: 東京
  • Year and Date: 2009-06-20
• [Presentation] ハブ毒蛋白質C型レクチン様ドメイン遺伝子の構造 (2007)
  • Author(s): 阿刀田 英子
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28