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Synthetic Studies of Peptide Natural Products and their Analogues by Fluorous Tag Method

Research Project

Project/Area Number 19510225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionNigata University of Phermacy and Applied Life Sciences

Principal Investigator

NAKAMURA Yutaka  Nigata University of Phermacy and Applied Life Sciences, 応用生命科学部, 准教授 (20267652)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords天然物有機化学 / 全合成 / フルオラス化学 / 環状ペプチド / 海洋天然物 / ペプチド性天然物 / コンビナトリアル合成
Research Abstract

A mixture of thiazole amino acid derivatives that different four fluorous tags was prepared by fluorous mixture synthesis. The mixture of fluorous-tagged thiazole amino acid derivatives was coupled with a mixture of oxazole amio acid derivative with four deferent oligoethylene glycol tags. The sixteen compound mixture was doubly demixed and detaged to provide sixteen hexapeptides. Finally, macrocyclization of these hexapeptides gave bistratamide H and fifteen unnatural analogues of bistratamide-type macrolactum.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008 2007 Other

All Presentation (10 results) Remarks (2 results)

  • [Presentation] Synthetic Study of Urukthapelstatin A by fluorous Tag Method2009

    • Author(s)
      Yutaka Nakamura, Saki, Ito, Masaru Kojima, Seiji Takeuchi
    • Organizer
      9th International Symposium of Fluorine Chemistry including International Symposium on Fluorous Technologies '09 (ISoFT'09)
    • Place of Presentation
      Jackson Lake Lodge, WY, USA
    • Year and Date
      2009-08-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Synthetic Study of Urukthapelstatin A by Fluorous Tag Method2009

    • Author(s)
      Yutaka Nakamura
    • Organizer
      19th International Symposium of Fluorine Chemistry
    • Place of Presentation
      Jackson Lake Lodge(Wyoming, USA)
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] フルオラスタグ保護基を用いた環状ペプチドAerucyclamide類の全合成研究2008

    • Author(s)
      中村豊、小田圭介、小島勝、武内征司
    • Organizer
      第1回フルオラス科学研究会(新潟)シンポジウム
    • Place of Presentation
      新潟薬科大学
    • Year and Date
      2008-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] フルオラスタグ法によるウルクタープルスタチンAの全合成研究2008

    • Author(s)
      中村豊、伊藤早紀、小林司、小島勝、武内征司
    • Organizer
      第1回フルオラス科学(新潟)シンポジウム
    • Place of Presentation
      新潟薬科大学
    • Year and Date
      2008-10-23
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] フルオラス保護基を用いた環状ペプチドurukthapelstatin Aの合成研究2008

    • Author(s)
      中村豊、小林司、杣木正人、小島勝、武内征司
    • Organizer
      第55回有機合成化学協会間等支部シンポジウム(野田シンポジウム)
    • Place of Presentation
      東京理科大学野田キャンパス
    • Year and Date
      2008-05-10
    • Related Report
      2009 Final Research Report
  • [Presentation] フルオラス保護基を用いた環状ペプチドurukthapelstatin A の合成研究2008

    • Author(s)
      中村 豊
    • Organizer
      第55回有機合成化学協会関東支部シンポジウム(野田シンポジウム)
    • Place of Presentation
      東京理科大学野田キャンパス
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ビストラタミド様マクロラクタムのフルオラスダブルミックチャー合成2008

    • Author(s)
      中村豊、太田美穗、小島勝、武内征司
    • Organizer
      日本化学会第88春季年会(2008)
    • Place of Presentation
      立教大学
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ビストラタミド様マクロラクタムのフルオラスダブルミックスチャー合成2008

    • Author(s)
      中村 豊
    • Organizer
      日本化学会第88春季年会(2008)
    • Place of Presentation
      立教大学
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] オリゴエチレングリコールおよびフルオラスタグを用いたビストラタミド様マクロラクタムのミックチャー合成2007

    • Author(s)
      中村豊、太田美穗、小島勝、武内征司
    • Organizer
      第54回有機合成化学協会関東支部シンポジウム(新潟シンポジウム)
    • Place of Presentation
      新潟薬科大学
    • Year and Date
      2007-12-02
    • Related Report
      2009 Final Research Report
  • [Presentation] オリゴエチレングリコールおよびフルオラスタグを用いたビストラタミド様マクロラクタムのミックスチャー合成2007

    • Author(s)
      中村 豊
    • Organizer
      第54回有機合成化学協会関東支部シンポジウム(新潟シンポジウム)
    • Place of Presentation
      新潟薬科大学
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://homepage.mac.com/yutakanakamura/My%20Website/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://homepage.mac.com/yutakanakamura/my%20Website/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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