Synthetic Studies of Peptide Natural Products and their Analogues by Fluorous Tag Method
| Project/Area Number |
19510225
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
|---|
Principal Investigator |
NAKAMURA Yutaka Nigata University of Phermacy and Applied Life Sciences, 応用生命科学部, 准教授 (20267652)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Keywords | 天然物有機化学 / 全合成 / フルオラス化学 / 環状ペプチド / 海洋天然物 / ペプチド性天然物 / コンビナトリアル合成 |
|---|
| Research Abstract |
A mixture of thiazole amino acid derivatives that different four fluorous tags was prepared by fluorous mixture synthesis. The mixture of fluorous-tagged thiazole amino acid derivatives was coupled with a mixture of oxazole amio acid derivative with four deferent oligoethylene glycol tags. The sixteen compound mixture was doubly demixed and detaged to provide sixteen hexapeptides. Finally, macrocyclization of these hexapeptides gave bistratamide H and fifteen unnatural analogues of bistratamide-type macrolactum.
|
Report
(4 results)
Research Products
(12 results)
