Dopaminergic mechanisms and operant behavior in rats
| Project/Area Number |
19530646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Fukushima University |
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Principal Investigator |
TSUTSUI Yuji Fukushima University, 共生システム理工学類, 准教授 (70286243)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | オペラント行動 / ドパミン作動性神経 / 側坐核 / 線条体 / レバー押し / ラット / マウス / 背側線条体 / D2ドパミン受容体 / ドパミン / 聴覚弁別 / リアクションタイム課題 / 学習 / ドーパミン作動性神経 / イムノトキシン / トランスジェニックマウス / D1受容体 / 6-hydroxydopamine |
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| Research Abstract |
In this research, we investigated the relationship between operant behavior in animals and the dopaminergic (DA) neurotransmission in the central nervous system. Inhibition of the DA transmission at the nucleus accumbens delayed the response initiation and made it difficult to acquire new learning tasks. On the other hand, impairment of the DA transmission in the striatum decreased the response speed when the impairment was provided to the D1 receptors, and decreased the accuracy of responses when the impairment was provided to the D2 receptors. These results suggested that the DA system in the nucleus accumbens and the striatum have an important role for the initiation and the control for operant behavior in animals.
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Report
(4 results)
Research Products
(8 results)
