| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this research, we investigated the relationship between operant behavior in animals and the dopaminergic (DA) neurotransmission in the central nervous system. Inhibition of the DA transmission at the nucleus accumbens delayed the response initiation and made it difficult to acquire new learning tasks. On the other hand, impairment of the DA transmission in the striatum decreased the response speed when the impairment was provided to the D1 receptors, and decreased the accuracy of responses when the impairment was provided to the D2 receptors. These results suggested that the DA system in the nucleus accumbens and the striatum have an important role for the initiation and the control for operant behavior in animals.
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