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Research on the central taste information processing related to food reward

Research Project

Project/Area Number 19530657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionOsaka University

Principal Investigator

SHIMURA Tsuyoshi  Osaka University, 大学院・人間科学研究科, 教授 (80150332)

Co-Investigator(Kenkyū-buntansha) 乾 賢  大阪大学, 人間科学研究科, 助教 (40324735)
Co-Investigator(Renkei-kenkyūsha) INUI Tadashi  大阪大学, 大学院・人間科学研究科, 助教 (40324735)
Research Collaborator SHINOHARA Yuhei  大阪大学, 大学院・人間科学研究科, 博士後期(課程2年次)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳内報酬系 / 味覚 / 摂食行動 / 神経回路 / 扁桃体 / 側坐核 / 腹側淡蒼球 / 神経伝達物質 / c-fos
Research Abstract

飲食物摂取に重要な役割を果たす味刺激に対する快・不快情動が、いかなる神経回路の働きで生じるのかを明らかにするために、味覚情報が脳内報酬系にアクセスする過程を調べた。味刺激に対する嗜好や嫌悪は大脳辺縁系に属する扁桃体内中心核の細胞集団の働きによって調節され、脳内報酬系のかなめである側坐核shell部および腹側淡蒼球を介して、実際の摂取や嫌悪の反応形成に関わっていることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (12 results)

  • [Journal Article] GABAergic transmission in the rat ventral pallidum mediates saccharin palatability shift in conditioned taste aversion2009

    • Author(s)
      Inui T, Shimura T, Yamamoto T
    • Journal Title

      European Journal of Neuroscience in press

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食行動の障害とその生物学的基盤2009

    • Author(s)
      八十島安伸、篠原祐平、志村剛
    • Journal Title

      大阪大学大学院人間科学研究科紀要 35

      Pages: 71-98

    • Related Report
      2008 Final Research Report
  • [Journal Article] 食行動の障害とその生物学的基盤2009

    • Author(s)
      八十島安伸, 篠原祐平, 志村 剛
    • Journal Title

      大阪大学大学院人間科学研究科紀要 35

      Pages: 71-98

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 甘味溶液の過剰摂取モデルの構築2008

    • Author(s)
      八十島安伸、篠原祐平、志村剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 453-454

    • NAID

      110007369666

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 嗜好性味刺激摂取行動における扁桃体中心核の役割2008

    • Author(s)
      篠原祐平、乾賢、八十島安伸、志村剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 303-306

    • NAID

      110007369624

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 味覚嫌悪学習獲得による嗜好性変化における腹側淡蒼球μオピオイド受容体の役割2008

    • Author(s)
      乾賢、山本隆、志村剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 333-336

    • NAID

      110007369632

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 味覚嫌悪学習獲得による嗜好性変化における腹側淡蒼球μオピオイド受容体の役割2008

    • Author(s)
      乾 賢, 山本 隆, 志村 剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 333-336

    • NAID

      110007369632

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 嗜好性味刺激摂取行動における扁桃体中心核の役割2008

    • Author(s)
      篠原祐平, 乾 賢, 八十島安伸, 志村 剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 303-306

    • NAID

      110007369624

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 甘味溶液の過剰摂取モデルの構築2008

    • Author(s)
      八十島安伸, 篠原祐平, 志村 剛
    • Journal Title

      日本味と匂学会誌 15

      Pages: 453-454

    • NAID

      110007369666

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the ventral pallidum GABAergic system in conditioned taste aversion2007

    • Author(s)
      Inui T, Shimura T, Yamamoto T
    • Journal Title

      effects of microinjections of a GABAA receptor antagonist on taste palatability of a conditioned stimulus. Brain Research 1164

      Pages: 117-124

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 側坐核カンナビノイドI型受容体による高嗜好性味溶液摂取行動の調節2007

    • Author(s)
      篠原祐平、志村剛、山本隆
    • Journal Title

      日本味と匂学会誌 14

      Pages: 361-364

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 側坐核カンナビノイドI型受容体による高嗜好性味溶液摂取行動の調節2007

    • Author(s)
      篠原祐平, 志村 剛, 山本 隆
    • Journal Title

      日本味と匂学会誌 14

      Pages: 361-364

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the ventral pallidum GABAergic system in conditioned taste aversion: effects of microinjections of a GABA_A receptor antagonist on taste palatability of a conditioned stimulus.2007

    • Author(s)
      Inui T, Shimura T, Yamamoto T
    • Journal Title

      Brain Research 1164

      Pages: 117-124

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 嗜好性味刺激摂取行動における扁桃体中心核の役割2008

    • Author(s)
      篠原祐平、乾賢、八十島安伸、志村剛
    • Organizer
      第42回日本味と匂学会
    • Place of Presentation
      富山市民プラザ
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 味覚嫌悪学習獲得による嗜好性変化における腹側淡蒼球μオピオイド受容体の役割2008

    • Author(s)
      乾賢、山本隆、志村剛
    • Organizer
      第42回日本味と匂学会
    • Place of Presentation
      富山市民プラザ
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 甘味溶液の過剰摂取モデルの構築2008

    • Author(s)
      八十島安伸、篠原祐平、志村剛
    • Organizer
      第42回日本味と匂学会
    • Place of Presentation
      富山市民プラザ
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 味覚嫌悪学習における脳内報酬系の役割2008

    • Author(s)
      乾賢、山本隆、志村剛
    • Organizer
      第42回日本味と匂学会
    • Place of Presentation
      富山市民プラザ
    • Year and Date
      2008-09-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] The stimulation of mu-opioid receptors in the ventral pallidum attenuates learned taste aversion in rats2008

    • Author(s)
      Inui T, Shimura T, Yamamoto T
    • Organizer
      15th International Symposium on Olfaction and Taste
    • Place of Presentation
      Hyatt Regency, San Francisco, CA, USA
    • Year and Date
      2008-07-24
    • Related Report
      2008 Final Research Report
  • [Presentation] The stimulation of mu-opioid receptors in the ventral pallidum attenuates learned taste aversion in rats.2008

    • Author(s)
      Inui, T., Shimura, T. &Yamamoto, T.
    • Organizer
      15^<th> International Symposium on Olfactionand Taste
    • Place of Presentation
      Hyatt Regency, San Francisco, CA, USA
    • Year and Date
      2008-07-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腹側淡蒼球へのμopioid受容体作動薬微量注入がCTAにおける味覚嗜好性の変化に及ぼす影響2008

    • Author(s)
      乾賢、志村剛、山本隆
    • Organizer
      第31回日本神経科学学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 味覚嫌悪学習の想起と消去における前頭前皮質の機能2008

    • Author(s)
      八十島安伸、志村剛
    • Organizer
      第31回日本神経科学学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 腹側淡蒼球へのμ opioid受容体作動薬微量注入がCTAにおける味覚嗜好性の変化に及ぼす影響2008

    • Author(s)
      乾 賢, 志村 剛, 山本 隆
    • Organizer
      第31回日本神経科学学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 側坐核カンナビノイドI型受容体による高嗜好性味溶液摂取行動の調節2007

    • Author(s)
      篠原祐平、志村剛、山本隆
    • Organizer
      日本味と匂学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2007-07-27
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] The GABAergic system in the ventral pallidum is involved in conditioned taste aversion in rats2007

    • Author(s)
      Inui T, Shimura T, Yamamoto T
    • Organizer
      15th Society for the Study of Ingestive Behavior
    • Place of Presentation
      Steamboat Springs, Colorado, USA
    • Year and Date
      2007-07-26
    • Related Report
      2008 Final Research Report
  • [Presentation] The GABAergic system in the ventral pallidum is involved in conditioned taste aversion in rats.2007

    • Author(s)
      Inui T, Siumura T, Yamamoto T
    • Organizer
      Society for the Study of Ingestive Behavior
    • Place of Presentation
      Steamboat Springs, Colorado, USA
    • Year and Date
      2007-07-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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