| Project/Area Number |
19530670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMADA Kazuyuki The Institute of Physical and Chemical Research, 動物実験支援ユニット, 専門職研究員 (50212288)
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| Co-Investigator(Renkei-kenkyūsha) |
HOMMA Chihiro 独立行政法人理化学研究所, 動物実験支援ユニット, テクニカルスタッフ
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 防御的覆い隠し行動 / ガラスビーズ覆い隠し行動 / 床材 / 情動 / 抗鬱薬 / 抗不安薬 / マウス / 穴掘り行動(digging) / 衝動性 / 動物モデル / 系統 / 防御行動 / 床敷 / 遺伝子改変動物 / 精神疾患 / 自発活動性 / 行動表現型解析 / ガラスビーズ / SSRI / セロトニン / ベンゾジアゼピン |
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| Research Abstract |
The aim of this study was to develop a rapid screening system for psychoactive drugs such as anxiolitics and/or untidepressants using the marble burying behavior (MB) in mice. First, the significant correlation was showed between physical properties of bedding materials and MB (FY 2007), and detailed replications were done and reported the results in an international journal (FY 2008-9). Then, it was shown that there were suitable bedding materials in the evaluation of some psychoactive drugs by MB (FY 2008). Furthermore, some results suggested that using an appropriate mouse strain should be more effective to evaluate certain drugs (FY 2009).
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