Exploitation of aerobic catalytic oxidation reaction under mild conditions
| Project/Area Number |
19550115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Okayama University of Science |
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Principal Investigator |
MURAHASHI Shun-Ichi Okayama University of Science, 客員教授(常勤扱) (60029436)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 酸素酸化反応 / C-H結合活性化 / ルテニウム触媒 / Biomimetic反応 / アミンの酸化 / シアノアミンの合成 / アミノ酸合成 / 不活性炭化水素の酸化 / 酸素酸化触媒反応 / アミンノ酸化 / オキシムの合成 / 選択的合成 / シアノ化反応 / αアミノニトリル / フラビン触媒 |
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| Research Abstract |
Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding α-aminonitriles, which are highly useful intermediates for organic synthesis. The reaction is the first demonstration of direct sp^3C-H bond activation α to nitrogen followed by carbon-carbon bond formation under aerobic oxidation conditions.
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Report
(4 results)
Research Products
(52 results)
