Synthesis of chiral quaternary ammonium polymers and their application to asymmetric reaction
| Project/Area Number |
19550122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
ITSUNO Shinichi Toyohashi University of Technology, 工学部, 教授 (50158755)
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| Co-Investigator(Kenkyū-buntansha) |
HARAGUCHI Naoki 豊橋技術科学大学, 工学部, 助教 (30378260)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 光学活性高分子 / 第四級アンモニウム塩 / ジアミン / ジハライド / 高分子不斉触媒 / 不斉アルキル化反応 / キラル第四級アンモニウム塩 / シンコナアルカロイド / キラルジアミン / キラルジハライド / 四級化 |
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| Research Abstract |
Although a substantial amount of work has been carried out using a side chain functionalized polymers, only a limited number of investigations have been performed to elucidate the use of main-chain functional polymers. The main-chain chiral polymer catalysts having rigid and sterically regular structure may have a better defined microenvironment at the catalytic sites and have allowed a systematic modification of their catalytic properties. We have synthesized two different types of chiral main-chain polymers containing quaternary ammonium salt structure. These chiral polymers were used as catalyst for asymmetric alkylation reaction of N-diphenylmethylidene glycine tert-butyl ester to give phenylalanine derivative in high level of enantioselectivity.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Effect of polymer Filling on Tensile Propaerties of Biomedical Porous Pure Titanium2008
Author(s)
Nakai, M., Niinomi, M., Akahori, T., Yamanoi, H., Itsuno, S., Haraguchi, N., Itoh, Y., Ogasawara, T., Onishi T.
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Journal Title
J. Jpn. Soc. Powder Powder Metallurgy 55
Pages: 312-317
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Peer Reviewed
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[Presentation] Medical Polymer Filling into Porous Titanium Fabricated by Powder Metallurgy and its Mechanical Functionality2009
Author(s)
Mitsuo Niinomi, Masaaki Nakai, Toshikazu Akahori, Harumi Tsutsumi, Shinichi Itsuno, Naoki Haraguchi, Yoshinori Itoh, Tadashi Ogasawara, Takashi Onishi, Taku Shindoh
Organizer
Euro PM2009
Place of Presentation
Copenhagen, Danmark
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[Presentation] Synthesis and Characterization of Polymer-supported Chiral Catalyst and Its Application to Asymmetric Transfer Hydrogenation of Ketones and Imines2008
Author(s)
Haraguchi, N., Arakawa, Y., Tsuru, K., Chiba, A., Itsuno, S.
Organizer
Japan-Korea Polymer Young Scientist Symposium
Place of Presentation
Niigata, Japan
Related Report
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