Development of fluorescent probes based on calixarene-coated water soluble quantum dots
| Project/Area Number |
19550157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
JIN Takashi Osaka University, 免疫学フロンティア研究センター, 特任教授 (80206367)
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| Co-Investigator(Kenkyū-buntansha) |
金城 政孝 北海道大学, 先端生命科学研究院, 教授 (70177971)
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| Co-Investigator(Renkei-kenkyūsha) |
KINJO Masataka 北海道大学, 大学院・先端生命科学研究院, 教授 (70177971)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | カリックスアレーン / 半導体量子ドット / 蛍光プローブ / 表面被覆 / 水溶化 / 表面修飾 / 蛍光 / プローブ / 半導体量子ドッド |
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| Research Abstract |
A novel method for preparing water-soluble highly fluorescent semiconductor quantum dots was developed using amphiphilic calixarenes as surface coating agents. The fluorescence efficiency of the resulting quantum dots was about 5 times higher than that of the quantum dots prepared by using simple thiol compounds as surface coating agents. The surface of the calixarene-coated quantum dots can be easily modified with biomolecules such as antibodies, showing their utility as fluorescent probes for live cell imaging.
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Report
(4 results)
Research Products
(34 results)
