Regioselective substitution of inositol based on its solubilization in DMSO and synthesis of inositol-based functional materials
Project/Area Number |
19550166
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemistry related to living body
|
Research Institution | Ehime University |
Principal Investigator |
WATANABE Yutaka Ehime University, 大学院・理工学研究科, 教授 (40114722)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 合成化学 / イノシトール / 選択的反応 / DMSO / 糖化学 / 位置選択的反応 / DMA / LiCl / 置換反応 / シリル化 |
Research Abstract |
A new method for the selective introduction of a substituent to inositol was developed by its solubilization in special solvents. The method realized one-step synthesis of a desired one or two substituted inositol derivative, which is required five steps at least to prepare in usual manner. We designed and made some derivatives to explore a biologically active and surface-active materials. The problematic solvents used here directed us to develop a new method for the synthesis of 3-ketoamide, and a tin-mediated substitution reaction.
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Report
(4 results)
Research Products
(17 results)