Development of Nitric Oxide Responsible Peptide-Metal Complex Conjugate and Its Application
Project/Area Number |
19550170
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemistry related to living body
|
Research Institution | Konan University |
Principal Investigator |
FUJII Satoshi Konan University, フロンティアサイエンス学部, 准教授 (80271518)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 生物無機化学 / ジチオスルバメート錯体 / 鉄錯体 / 一酸化窒素 / センサータンパク質 / ヘリックスバンドル / ペプチド / ドテッグデリバリーシステム / 蛍光物質 / ジチオカルバメート錯体 / ドラッグデリバリーシステム |
Research Abstract |
We succeeded in developing an iron complex that can make a three helix bundle structure with helical peptides attached to the dithiocarbamate ligand. This iron complex has high affinity toward nitric oxide. Thermal stability of the bundle structure can be controlled by the peptide length and the bundle is stable at around 37℃ with 22 amino acid residues. Moreover, the bundle is collapsed with the nitric oxide binding to the iron ion. These results suggest that this complex can be used as a carrier for drug delivery system that responds to inflammation and nitric oxide.
|
Report
(4 results)
Research Products
(12 results)