| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
We clarified how Lipopolysaccharide (LPS), the ligand of innate immune response, and biomembrane interact by using a solid-state NMR. First, we examined the effect of LPS on membrane morphology and LPS distribution patterns in the membrane based on the miscibility between LPS and individual phospholipid compositions. Then, molecular motions of the LPS and phospholipids were evaluated in the pure phospholipid membrane and raft-forming membrane. Further, we clarified that LPS induces expansion of the raft area in the raft-forming membrane.
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