Development of 3D cell irradiation system using 3D Micron CT

• Project/Area Number: 19560836
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nuclear engineering
• Research Institution: Tohoku University
• Principal Investigator: MATSUYAMA Shigeo Tohoku University, 大学院・工学研究科, 准教授 (70219525)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Hiromichi 東北大学, サイクロトロンRIセンター, 教授 (00166654) ; KIKUCHI Youhei 東北大学, 大学院・工学研究科, 助教 (50359535)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ミクロンCT / マイクロビーム / 形態観察 / 細胞照射システム

Research Abstract

細胞を3次元的に形態観察し、イオンビーム照射することのできるシステムを構築するために、照準システムの開発とマイクロビームシステムと3次元ミクロンCTの大幅な高性能化を図った。その結果、マイクロビームシステムは数100ナノメートルの分解能を達成し、数10ミクロンの大きさの細胞を3次元的に鮮明にとらえることが可能となり、照準システムにより照射が可能となった。

Research Products

• [Journal Article] Upgrading of the 4.5 MV Dyanamitron accelerator at Tohoku University for microbeam and nanobeam applications (2009)
  • Author(s): S.Matsuyama, K.Ishii, M.Fujisawa, Y. Kawamura, S.Tsuboi, K.Yamanaka, M.Watanabe, Y.Hashimoto, S.Ohkura, M.Fujikawa, T.Nagaya, K.Komatsu, H.Yamazaki, Y.Kikuchi
  • Journal Title: Nuclear Instrument and Method in Physics Research(掲載決定)
  • Peer Reviewed
• [Journal Article] Upgrading of the 4.5 MV Dyanamitron accelerator at Tohoku University for microbeam and nanobeam applications (2009)
  • Author(s): S. Matsuyama, et.al.
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section B (印刷中)
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): S.Matsuyama, K.Ishii, H.Yamazaki, Y.Kikuchi, M.Fujiwara, Y.Kawamura, K.Yamanaka, M. Watanabe, S.Tsuboi, P.Pelicon and M.Zitnik
  • Journal Title: International Journal of PIXE Vol.18(3&4) Pages: 199-208
  • Peer Reviewed
• [Journal Article] μ-CT Images of the Egg of Drosophila (2008)
  • Author(s): S.Ohkura, K.Ishii, S.Matsuyama, H.Yamazaki, A.Terakawa, Y.Kikuchi, M.Fujiwara, Y. Kawamura, S.Tsubboi, K.Yamanaka, M.Watanabe and M.Fujikawa
  • Journal Title: International Journal of PIXE Vol.18(3&4) Pages: 167-174
  • Peer Reviewed
• [Journal Article] Microbeam analysis of yellow sand dust particles (2008)
  • Author(s): S. Matsuyama, K. Ishii, H. Yamazaki, Y. Kikuchi, Y. Kawamura, R. Oyama, K. Yamanaka, T. Yamamoto, M. Watanabe, S. Tsuboil and K. Arao
  • Journal Title: X-ray Spectrometry 37 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Characterization of Aerosol Particles in a Mechanical Workshop Environment (2008)
  • Author(s): S. Matsuyama, et.al.
  • Journal Title: International Journal of PIXE 18(3&4) Pages: 199-208
  • Peer Reviewed
• [Journal Article] μ-CT Images of the Egg of Drosophila (2008)
  • Author(s): S. Ohkura, et.al.
  • Journal Title: International Journal of PIXE 18(3&4) Pages: 167-174
  • Peer Reviewed
• [Journal Article] Microbeam analysis of yellow sand dust particles (2008)
  • Author(s): S. Matsuyama, et. al.
  • Journal Title: X-ray Spectrometry 37 Pages: 151-155
  • Peer Reviewed
• [Journal Article] DEVELOPMENT OF MICROBEAM SCANNING SYSTEM (2007)
  • Author(s): R.Oyama, S.Matsuyama, K.Ishii, H.Yamazaki, Y.Kikuchi, K.Inomata, Y.Watanabe, A.Ishizaki, Y.Kawamura, T.Yamaguchi, G..Momose
  • Journal Title: International Journal of PIXE Vol. 17(1&2) Pages: 23-31
  • Peer Reviewed
• [Journal Article] Progress and application of the Tohoku microbeam system, Nuclear Instruments and Methods in Physics (2007)
  • Author(s): S. Matsuyama, K. Ishii, H. Yamazaki, Y. Kikuchi, K. Inomata, Y. Watanabe, A. Ishizaki, R. Oyama, Y. Kawamura, T. Yamaguchi, G.Momose, M.Nagakura, M.Takahashi, T.Kamiya
  • Journal Title: Research Section B260 Pages: 55-64
  • Peer Reviewed
• [Journal Article] In-vivo Elemental Analysis by PIXE-μ-CT (2007)
  • Author(s): Y. Kawamura, K. Ishii, H. Yamazaki, S. Matsuyama, Y.Kikuchi, T.Yamaguchi, Y. Watanabe, R. Oyama, G. Momose, A. Ishizaki, S. Tsuboi , K. Yamanaka and M. Watanabe
  • Journal Title: International Journal of PIXE Vol. 17(1&2) Pages: 41-46
  • Peer Reviewed
• [Journal Article] 3D-imaging using micro-PIXE (2007)
  • Author(s): K.Ishii, S. Matsuyama, Y. Watanabe, Y. Kawamura, T. Yamaguchi, R. Oyama, G. Momose, A. Ishizaki, H. Yamazaki and Y. Kikuchi
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section A571 Pages: 64-68
  • Peer Reviewed
• [Journal Article] DEVELOPMENT OF MICROBEAM SCANNING SYSTEM (2007)
  • Author(s): R. Oyama, et. al.
  • Journal Title: International Journal of PIXE 17 Pages: 23-31
  • Peer Reviewed
• [Journal Article] Progress and application of the Tohoku microbeam system (2007)
  • Author(s): S. Matsuyama, et. al.
  • Journal Title: Nuclear Instruments and Methods B260 Pages: 55-64
  • Peer Reviewed
• [Journal Article] In-vivo Elemental Analysis by PIXE-μ-CT (2007)
  • Author(s): Y. Kawamura, et. al.
  • Journal Title: International Journal of PIXE 17 Pages: 41-46
  • Peer Reviewed
• [Presentation] マイクロイオンビームを用いたエアロゾル粒子の個別粒子分析 (2008)
  • Author(s): 松山成男、石井慶造、山崎浩道、菊池洋平、藤原充啓、川村悠、山中健太郎、渡辺未樹、大倉暁、藤川誠、橋本悠太郎
  • Organizer: 第9回イオンビームによる表面・界面解析特別研究会
  • Place of Presentation: 高知(高知)
• [Presentation] Upgrading of the 4.5 MV Dynamitron Accelerator at Tohoku University for Micro- and Nanobeam Application (2008)
  • Author(s): S. Matsuyama, K. Ishii, M. Fujisawa, T. Nagaya, K. Komatsu, Y. Hashimo, Y. Kawamura, H. Yamazaki and Y. Kikuchi
  • Organizer: 11th International Conference on Nuclear Microprobe Technology and Application
  • Place of Presentation: Debrecen, Hungary
• [Presentation] Analysis of Single Aerosol Particles Collected in a Factory and a Laboratory (2008)
  • Author(s): S. Matsuyama, K. Ishii, H. Yamazaki, Y. Kikuchi, Y. Kawamura, K. Yamanaka, M.Watanabe, S. Tsuboi, P. Primoz and M. Zitnik
  • Organizer: Sixth International Symposium Dedicated to advances in biological,medical, and environmental applications of Proton-Induced X-Ray Emission BioPIXE6
  • Place of Presentation: Richland, Washington, USA
• [Presentation] Micron-CT For The Egg of the Drosophila (2008)
  • Author(s): S. Okura, K. Ishii, H. Yamazaki, S. Matsuyama, A. Terakawa, Y. Kikuchi, M. Fujiwara, Y. Kawamura, S. TsubK. Yamanaka, M. Watanabe and M. Fujikawa
  • Organizer: Sixth International Symposium Dedicated to advances in biological, medical, and environmental applications of Proton-Induced X-Ray Emission BioPIXE6
  • Place of Presentation: Richland, Washington, USA
• [Presentation] Development of 3D micron-CT using PIXE (2008)
  • Author(s): Y.Kawamura, K.Ishii, H.Yamazaki, S.Matsuyama, Y.Kikuchi, T.Yamaguchi, Y.Watanabe, R.Oyama, G.Momose and A.Ishizaki
  • Organizer: XI International Conference on Particle Induced X-ray Emission and Its Analytical Application
  • Place of Presentation: Puebla, Mexico
• [Presentation] Micronbeam analysis of yellow sand dust particles (2008)
  • Author(s): S.Matsuyama, K.Ishii, H.Yamazaki, Y.Kikuchi, Y.Kawamura, R.Oyama, T. Yamamoto, A.Ishizaki and G.Momose
  • Organizer: XI International Conference on Particle Induced X-ray Emission and Its Analytical Application
  • Place of Presentation: Puebla Mexico
• [Presentation] Upgrading of the 4.5 MV Dynamitron Accelerator at Tohoku University for Micro- and Nanobeam Application (2008)
  • Author(s): S. Matsuyama, et.al.
  • Organizer: 11^<th> International Conference on Nuclear Microprobe Technology and Application
  • Place of Presentation: Debrecen, Hungary
• [Presentation] Microbeam analysis of yellow sand dust particles (2007)
  • Author(s): S. Matsuyama et. al.
  • Organizer: XI INTERNATIONAL CONFERENCE ON PIXE AND ITS ANALYTICAL APPLICATIONS
  • Place of Presentation: Puebla, Mexico
• [Presentation] ヒト肺細胞中の発ガン性クロム化合物の3次元CTイメージング~SAKURAプロジェクト~
  • Author(s): 松山成男、石井慶造、山崎浩道、菊池洋平、寺川貴樹、藤原充啓、川村悠、山中健太郎、坪井真太郎、渡辺未樹、Richard Ortega、Guillaume Deves、Asuncion Carmona
  • Organizer: 第25回PIXEシンポジウム
  • Place of Presentation: 群馬