Glucose transport mechanism in the cochlea stria vascularis

• Project/Area Number: 19570058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: ANDO Motonori Okayama University, 大学院・教育学研究科, 准教授 (20222789)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 組織構築 / 辺縁細胞 / 基底細胞 / グルコーストランスポーター / RT-PCR / 共焦点レーザー顕微鏡 / 内耳 / 血管条

Research Abstract

内耳血管条機能の根幹を支える糖輸送機構を明らかにする目的で, それに関わる糖輸送分子の組織特異的な遺伝子発現およびタンパク質発現を明らかにした。その結果, 糖輸送体分子の一つであるGLUT-1型が血管条構成細胞の中で基底細胞と血管構成細胞に発現していることや, 新たに複数のGLUT型の輸送体の遺伝子発現を確認した。血管条では複数の促進拡散型糖輸送体が連携してその高いエネルギー代謝活性をを支えているものと考えられた。

Research Products

• [Journal Article] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect (2009)
  • Author(s): Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T.
  • Journal Title: J Thorac Cardiovasc Surg 137 Pages: 223-231
  • Peer Reviewed
• [Journal Article] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. (2009)
  • Author(s): Katare RG
  • Journal Title: J Thorac Cardiovasc Surg 137 Pages: 223-231
  • Peer Reviewed
• [Journal Article] Cellular localization of facilitated glucose transporter 1(GLUT-1)in the cochlea stria vascularis : its possible contribution to the transcellular glucose pathway (2008)
  • Author(s): Ando M, Edamatsu M, Fukuizumi S, Takeuchi S.
  • Journal Title: Cell Tissue Res 331 Pages: 763-769
  • Peer Reviewed
• [Journal Article] Cellular localization of facilitated glucose transporter 1 (GLUT-1) in the cochlear stria vascularis: its possible contribution to the transcellular glucose pathway. (2008)
  • Author(s): Ando M.
  • Journal Title: Cell Tissue Res. 331 Pages: 763-769
  • Peer Reviewed
• [Journal Article] Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin (2007)
  • Author(s): Kuwabara M, Kakinuma Y, Katare RG, Ando M, Yamasaki F, Doi Y, Sato T.
  • Journal Title: FEBS Lett 581 Pages: 4821-4830
  • Peer Reviewed
• [Journal Article] Granulocyte colony-stimulating factor activates Wnt signal to sustain gap junction function through recruitment of beta-catenin and cadherin. (2007)
  • Author(s): Kuwabara M.
  • Journal Title: FEBS Lett. 581 Pages: 4821-4830
  • Peer Reviewed
• [Presentation] Cell-specific expression of glucose transporter in the cochlear stria vascularis (2008)
  • Author(s): Edamatsu M, Enomoto T, Fukuizumi S, Ando M.
  • Organizer: 第79回日本動物学会大会
  • Place of Presentation: @Fukuoka
  • Year and Date: 2008-09-05
• [Presentation] Cell-specific expression of glucose transporter in the cochlear stria vascularis. (2008)
  • Author(s): Edamatsu M.
  • Organizer: 第79回 日本動物学会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-05
• [Presentation] Glucose transport mechanism in the cochlear stria vascularis (2007)
  • Author(s): Edamatsu M, Fukuizumi S, Ando M.
  • Organizer: 第78回日本動物学会大会
  • Place of Presentation: @Hirosaki
  • Year and Date: 2007-09-20
• [Presentation] Glucose transport mechanism in the cochlear stria vascularis. (2007)
  • Author(s): Edamatsu M.
  • Organizer: 第78回 日本動物学会大会
  • Place of Presentation: 弘前市
  • Year and Date: 2007-09-20
• [Remarks]
  • URL: http://ed-www.ed.okayama-u.ac.jp/~rika/cell_physiology/index.html