Mechanisms determining epithelial cell fate decisions by mesenchyme
| Project/Area Number |
19570062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TOMOOKA Yasuhiro Tokyo University of Science, 基礎工学部・生物工学科, 教授 (10197949)
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| Co-Investigator(Kenkyū-buntansha) |
UMEZU Tomohiro 東京理科大学, 基礎工学部・生物工学科, 助教 (40385547)
SAKAKURA Teruyo 三重大学, 医学研究科, 名誉教授 (80073120)
OKADA Atsumasa 東京理科大学, 基礎工学部・生物工学科, 助教 (00535809)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 上皮・間充織相互作用 / 形態形成 / 間充織因子 / クローン株細胞 / p53欠損マウス / クローン性株細胞 |
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| Research Abstract |
Mesenchyme plays critical roles in "fate-determination of undetermined epithelial cell" during organogenesis. Because of the complexity of tissue interactions in the process, however, little is known about the precise mechanisms. We have established a model for studying the process by establishing epithelial and mesenchymal cell lines, and then identified Follistatin-like 1 as one of the mesenchymal factors determining epithelial cell fate.
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Report
(4 results)
Research Products
(42 results)
